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CYP46A1 Antibody (PA5-115086) in IHC (P)
Immunohistochemistry analysis of CYP46A1 in mouse brain tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115086) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115086
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CYP46A1(Accession Q9Y6A2), corresponding to amino acid residues Q213-E263.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899722
Product Specific Information
Antibody detects endogenous levels of total Cytochrome P450 46A1.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CH24H; Cholesterol 24-hydroxylase; Cholesterol 24-monooxygenase; Cholesterol 24S-hydroxylase; cholestrol 24-hydroxylase; Cytochrome P450 46A1; cytochrome P450, 46 (cholesterol 24-hydroxylase); cytochrome P450, 46a1 (cholesterol 24-hydroxylase); cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Gene Aliases: CP46; CYP46; CYP46A1
UniProt ID: (Human) Q9Y6A2, (Mouse) Q9WVK8
Entrez Gene ID: (Human) 10858, (Mouse) 13116
iron ion binding
steroid hydroxylase activity
heme binding
cholesterol 24-hydroxylase activity
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
metal ion binding
oxidoreductase
oxygenase
metabolite interconversion enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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