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Invitrogen
Candida albicans PRA1 Polyclonal Antibody
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Application
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Candida albicans PRA1 Antibody (PA5-117546) in WB
Western Blot analysis of PRA1 using Candida albicans PRA1 Polyclonal Antibody (Product # PA5-117546) at 4.7 µg/mL. Positive WB detected in Recombinant protein. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 55 kDa. Observed band size: 55 kDa
Product Details
PA5-117546
Product Specifications
Species Reactivity
Fungi
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299aa)
Conjugate
Unconjugated
Form
Liquid
Concentration
2.948 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2902175
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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