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Product Details
11055-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cathepsin F Fusion Protein Ag1521 (136-484 aa encoded by BC011682)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EPKSAFTQG SAMISSLSQN HPDNRNETFS SVISLLNEDP LSQDLPVKMA SIFKNFVITY NRTYESKEEA RWRLSVFVNN MVRAQKIQAL DRGTAQYGVT KFSDLTEEEF RTIYLNTLLR KEPGNKMKQA KSVGDLAPPE WDWRSKGAVT KVKDQGMCGS CWAFSVTGNV EGQWFLNQGT LLSLSEQELL DCDKMDKACM GGLPSNAYSA IKNLGGLETE DDYSYQGHMQ SCNFSAEKAK VYINDSVELS QNEQKLAAWL AKRGPISVAI NAFGMQFYRH GISRPLRPLC SPWLIDHAVL LVGYGNRSDV PFWAIKNSWG TDWGEKGYYY LHRGSGACGV NTMASSAVVD (136-484 aa encoded by BC011682)
Target Information
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cathepsin F; CATSF; HGNC:2531
Gene Aliases: AI481912; CATSF; CLN13; CTSF
UniProt ID: (Human) Q9UBX1, (Mouse) Q9R013
Entrez Gene ID: (Human) 8722, (Rat) 361704, (Mouse) 56464
Performance Guarantee
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