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May serve as a "flippase" as well as a glucosyltransferase that transfers glucose to ceramide. It Catalyzes; UDP-glucose + Nacylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ceramide glucosyltransferase; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21; GCS; GLCT-1; Glucosylceramide synthase; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
Gene Aliases: AU043821; C80537; Epcs21; GCS; GlcT-1; GLCT1; UGCG; Ugcgl
UniProt ID: (Human) Q16739, (Mouse) O88693
Entrez Gene ID: (Human) 7357, (Mouse) 22234
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