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Invitrogen
Cerebellin 4 Polyclonal Antibody
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Application
FIGURE: 1 / 4
Cerebellin 4 Antibody (PA5-36472) in WB
Western blot analysis of Cerebellin 4 in Lane 1: the Brain tissue lysate of mouse (40 µg), Lane 2: the Brain tissue lysate of rat (40 µg), Lane 3: U-87MG whole cell lysate (20 µg), Lane 4: L02 whole cell lysate (20 µg). Samples were incubated with Cerebellin 4 polyclonal antibody (Product # PA5-36472) at a dilution of 1:500.
Product Details
PA5-36472
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 148-197 of human Cerebellin 4
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553539
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 27 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other's degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cerebellin 4 precursor protein; cerebellin precursor-like 1; Cerebellin-4; Cerebellin-like glycoprotein 1; Cerebellin4
Gene Aliases: AI848962; CBLN4; CBLNL1; UNQ718/PRO1382
UniProt ID: (Human) Q9NTU7, (Mouse) Q8BME9
Entrez Gene ID: (Human) 140689, (Rat) 499947, (Mouse) 228942
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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