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Application
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Chitotriosidase Antibody (PA5-82395) in IHC (P)
Immunohistochemical analysis of Chitotriosidase in human bone marrow using Chitotriosidase Polyclonal Antibody (Product # PA5-82395) shows moderate cytoplasmic positivity in hematopoietic cells.
Product Details
PA5-82395
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CHIT1. Recombinant protein control fragment (Product #RP-90229).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2789554
Product Specific Information
Immunogen sequence: FDDVESFKTK VSYLKQKGLG GAMVWALDLD DFAGFSCNQG RYPLIQTLRQ ELSLPYLPSG TPELEVPKPG QPSEPEHGPS PGQDTFCQGK ADGLYPNPRE RSSFYSCAAG RLFQQSCPTG LVFSNSCKCC TWN
Target Information
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chitinase 1 (chitotriosidase); Chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 3.2.1.14; FLJ00314; MGC125322; plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
Gene Aliases: CHI3; CHIT; CHIT1; CHITD
UniProt ID: (Human) Q13231
Entrez Gene ID: (Human) 1118
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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