Product References
Curcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin.
Folia morphologica
Kobutree P,Tothonglor A,Roumwong A,Jindatip D,Agthong S
34-1600 was used in Western Blotting to investigate if cisplatin causes blood-nerve barrier disruption in the nerves and might result in neuropathy.
Wed Oct 18 00:00:00 EDT 2023
An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone.
Experimental & molecular medicine
Lee E,Lee EA,Kong E,Chon H,Llaiqui-Condori M,Park CH,Park BY,Kang NR,Yoo JS,Lee HS,Kim HS,Park SH,Choi SW,Vestweber D,Lee JH,Kim P,Lee WS,Kim I
34-1600 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to reveal that the normal-to-tumor vascular transition is spatiotemporally associated with GBM invasion and may be controlled by Tie2 activation via a novel mechanism of action.
Wed Feb 01 00:00:00 EST 2023
CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice.
Journal of translational medicine
Lin J,Xu Y,Guo P,Chen YJ,Zhou J,Xia M,Tan B,Liu X,Feng H,Chen Y
34-1600 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to reveal that severe peripheral inflammation increased CCL5/CCR5 axis activation in multiple inflammatory cell types, including microglia, astrocytes, and monocytes, and aggravated BBB disruption and neurobehavioral dysfunction after ICH, possibly in part through the JAK2/STAT3 signaling pathway.
Tue Mar 14 00:00:00 EDT 2023
Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M).
Cells
Awad K,Barmeyer C,Bojarski C,Nagel O,Lee IM,Schweiger MR,Schulzke JD,Bücker R
34-1600 was used in Western Blotting to investigate the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type IBS.
Thu Jan 05 00:00:00 EST 2023
Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.
Nature communications
Freitas-Andrade M,Comin CH,Van Dyken P,Ouellette J,Raman-Nair J,Blakeley N,Liu QY,Leclerc S,Pan Y,Liu Z,Carrier M,Thakur K,Savard A,Rurak GM,Tremblay MÈ,Salmaso N,da F Costa L,Coppola G,Lacoste B
34-1600 was used in Western Blotting to identify astroglial Hmgb1 as an important player in postnatal gliovascular maturation.
Wed Aug 16 00:00:00 EDT 2023
Siponimod As a Novel Inhibitor of Retinal Angiogenesis: In Vitro and In Vivo Evidence of Therapeutic Efficacy.
The Journal of pharmacology and experimental therapeutics
Alshaikh RA,Zaki RGE,El Din RAS,Ryan KB,Waeber C
34-1600 was used in Immunocytochemistry to investigate the potential of Siponimod for the inhibition of ocular angiogenesis in vitro and in vivo.
Tue Aug 01 00:00:00 EDT 2023
Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood-brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke.
Journal of nanobiotechnology
Li Y,Liu B,Zhao T,Quan X,Han Y,Cheng Y,Chen Y,Shen X,Zheng Y,Zhao Y
34-1600 was used in Western Blotting to demonstrate that Cav-1 aggravated BBB permeability in acute ischemic stroke, and BMSC-EVs exerted similar antagonistic efficacy to BEC-EVs on Cav-1-dependent ZO-1 and Claudin-5 endocytosis.
Tue Feb 28 00:00:00 EST 2023
Amino acid solution mitigates hypothermia response and intestinal damage following exertional heat stroke in male mice.
Physiological reports
King MA,Grosche A,Ward SM,Ward JA,Sasidharan A,Mayer TA,Plamper ML,Xu X,Ward MD,Clanton TL,Vidyasagar S
34-1600 was used in Immunohistochemistry to determine if a five amino acid oral rehydration solution (5AAS), specifically designed for the protection of the gastrointestinal lining, would prolong time to exertional heat stroke (EHS), maintain gut function and dampen the systemic inflammatory response (SIR) measured during EHS recovery.
Mon May 01 00:00:00 EDT 2023
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Translational stroke research
Yu R,Kim NS,Li Y,Jeong JY,Park SJ,Zhou B,Oh WJ
34-1600 was used in Western Blot to investigate whether Sema3E-Plexin-D1 signaling was involved in cerebrovascular remodeling after ischemic injury.
Tue Feb 01 00:00:00 EST 2022
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis.
Fluids and barriers of the CNS
Zhang Y,Wang L,Pan Q,Yang X,Cao Y,Yan J,Wang Y,Tao Y,Fan R,Sun X,Li L
34-1600 was used in Western Blot, Immunohistochemistry (Frozen) to investigate the effect of CYM-5442 on vesicle transcytosis, we downregulated and upregulated Mfsd2a expression using a specific AAV prior to evaluation of the TBI model.
Mon Jul 11 00:00:00 EDT 2022
Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis.
Fluids and barriers of the CNS
Zhang Y,Wang L,Pan Q,Yang X,Cao Y,Yan J,Wang Y,Tao Y,Fan R,Sun X,Li L
34-1600 was used in Western Blot, Immunohistochemistry (Frozen) to investigate the effect of CYM-5442 on vesicle transcytosis, we downregulated and upregulated Mfsd2a expression using a specific AAV prior to evaluation of the TBI model.
Mon Jul 11 00:00:00 EDT 2022
Immunohistochemical Analysis of Tight Junction Proteins.
Methods in molecular biology (Clifton, N.J.)
Greene C,Campbell M
34-1600 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to assess tight junction expression and localization and an ImageJ-based method for quantifying tight junction staining in healthy and diseased states.
Fri Jun 24 00:00:00 EDT 2022
Pharmacological inhibition of FOXO1 promotes lymphatic valve growth in a congenital lymphedema mouse model.
Frontiers in cell and developmental biology
Ogunsina O,Banerjee R,Knauer LA,Yang Y
34-1600 was used in Immunohistochemistry to indicate that pharmacological inhibition of FOXO1 can be explored as a viable strategy to resolve valve defects in congenital lymphedema.
Tue Feb 07 00:00:00 EST 2023
Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier.
Cell reports. Medicine
Chang JH,Greene C,Frudd K,Araujo Dos Santos L,Futter C,Nichols BJ,Campbell M,Turowski P
34-1600 was used in Immunohistochemistry to indicate that caveolar transport at the adult BBB is agonist inducible and that METH can enhance drug delivery to the CNS.
Tue Jan 18 00:00:00 EST 2022
Predominance of Escherichia-Shigella in Gut Microbiome and Its Potential Correlation with Elevated Level of Plasma Tumor Necrosis Factor Alpha in Patients with Tuberculous Meningitis.
Microbiology spectrum
Li S,Guo J,Liu R,Zhang F,Wen S,Liu Y,Ren W,Zhang X,Shang Y,Gao M,Lu J,Pang Y
34-1600 was used in Western Blotting to compared gut microbiota compositions and blood cytokine profiles of tuberculous meningitis (TBM) patients, pulmonary tuberculosis patients, and healthy controls.
Wed Dec 21 00:00:00 EST 2022
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.
Nature communications
Dion-Albert L,Cadoret A,Doney E,Kaufmann FN,Dudek KA,Daigle B,Parise LF,Cathomas F,Samba N,Hudson N,Lebel M,Campbell M,Turecki G,Mechawar N,Menard C
34-1600 was used in Immunohistochemistry to report that chronic social and subchronic variable stress promotes blood-brain barrier alterations in mood-related brain regions of female mice.
Mon Jan 10 00:00:00 EST 2022
Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor's Presence.
Biomolecules
Deissler HL,Rehak M,Wolf A
34-1600 was used in Western Blotting to conclude that several days after the addition of VEGF-A165 to iBREC, barrier dysfunction is mainly sustained by increased paracellular flow and impaired adhesion.
Mon May 23 00:00:00 EDT 2022
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Journal of neuroinflammation
Yan J,Zhang Y,Wang L,Li Z,Tang S,Wang Y,Gu N,Sun X,Li L
34-1600 was used in Immunohistochemistry to find that COG1410 improved neurological functions within 3 d, as well as neurological functions and brain electrophysiological activity at 2 weeks after CCI.
Sat Dec 03 00:00:00 EST 2022
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Journal of neuroinflammation
Yan J,Zhang Y,Wang L,Li Z,Tang S,Wang Y,Gu N,Sun X,Li L
34-1600 was used in Immunohistochemistry to find that COG1410 improved neurological functions within 3 d, as well as neurological functions and brain electrophysiological activity at 2 weeks after CCI.
Sat Dec 03 00:00:00 EST 2022
Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner.
eLife
Richards M,Nwadozi E,Pal S,Martinsson P,Kaakinen M,Gloger M,Sjöberg E,Koltowska K,Betsholtz C,Eklund L,Nordling S,Claesson-Welsh L
34-1600 was used in Immunohistochemistry (PFA fixed) to identify structural and functional in vivo characteristics of the endothelial cell barrier.
Thu Jul 21 00:00:00 EDT 2022
Preventing VEGF-Mediated Vascular Permeability by Experimentally Potentiating BBB Characteristics in Endothelial Cells.
Methods in molecular biology (Clifton, N.J.)
Kim BK,Canonica J,Roudnicky F,Westenskow PD
34-1600 was used in ELISA, Immunocytochemistry, Western Blot to generate relevant blood-brain and blood-retinal barrier models from stem cells.
Tue Apr 26 00:00:00 EDT 2022
Brain Targeting, Antioxidant Polymeric Nanoparticles for Stroke Drug Delivery and Therapy.
Small (Weinheim an der Bergstrasse, Germany)
Wu H,Peng B,Mohammed FS,Gao X,Qin Z,Sheth KN,Zhou J,Jiang Z
34-1600 was used in Western Blotting to show ASPTT NPs are capable of efficient encapsulation and delivery of glyburide to achieve anti-edema and antioxidant combination therapy, resulting in therapeutic benefits significantly greater than those by either the NPs or glyburide alone.
Wed Jun 01 00:00:00 EDT 2022
Microbial-derived metabolites induce actin cytoskeletal rearrangement and protect blood-brain barrier function.
iScience
Knox EG,Aburto MR,Tessier C,Nagpal J,Clarke G,O'Driscoll CM,Cryan JF
34-1600 was used in Immunocytochemistry-immunofluorescence to identify the actin cytoskeletal dynamics as another target further illuminating how SCFAs can influence BBB physiology.
Thu Dec 22 00:00:00 EST 2022
BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury.
International journal of molecular medicine
He X,Huang Y,Liu Y,Zhang X,Yue P,Ma X,Miao Z,Long X,Yang Y,Wan X,Lei J,Shu K,Lei T,Gan C,Zhang H
34-1600 was used in Western Blotting to study the potential effects of BAY on microglial phenotype and neuroinflammation after TBI.
Sat Jan 01 00:00:00 EST 2022
BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury.
International journal of molecular medicine
He X,Huang Y,Liu Y,Zhang X,Yue P,Ma X,Miao Z,Long X,Yang Y,Wan X,Lei J,Shu K,Lei T,Gan C,Zhang H
34-1600 was used in Western Blotting to study the potential effects of BAY on microglial phenotype and neuroinflammation after TBI.
Sat Jan 01 00:00:00 EST 2022
Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders.
Science (New York, N.Y.)
Martin M,Vermeiren S,Bostaille N,Eubelen M,Spitzer D,Vermeersch M,Profaci CP,Pozuelo E,Toussay X,Raman-Nair J,Tebabi P,America M,De Groote A,Sanderson LE,Cabochette P,Germano RFV,Torres D,Boutry S,de Kerchove d'Exaerde A,Bellefroid EJ,Phoenix TN,Devraj K,Lacoste B,Daneman R,Liebner S,Vanhollebeke B
34-1600 was used in Immunocytochemistry-immunofluorescence to reveal that the signaling specificity of Wnt ligands is adjustable and defines a modality to treat CNS disorders by normalizing the BBB.
Fri Feb 18 00:00:00 EST 2022
Autophagic degradation of claudin-5 mediated by its binding to a Clostridium perfringens enterotoxin fragment modulates endothelial barrier permeability.
FEBS letters
Lin P,Tan R,Yu P,Li Y,Mo Y,Li W,Zhang J
34-1600 was used in Immunocytochemistry-immunofluorescence to explore the mechanisms regulating the dynamics of membranous claudin-5 and BBB permeability.
Fri Apr 01 00:00:00 EDT 2022
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis.
eLife
Kuo A,Checa A,Niaudet C,Jung B,Fu Z,Wheelock CE,Singh SA,Aikawa M,Smith LE,Proia RL,Hla T
34-1600 was used in Immunohistochemistry (PFA fixed) to suggest that EC-derived SL metabolites are in constant flux between the vasculature, circulatory elements, and parenchymal cells of non-CNS organs.
Wed Oct 05 00:00:00 EDT 2022
Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome.
Fluids and barriers of the CNS
Sifat AE,Archie SR,Nozohouri S,Villalba H,Zhang Y,Sharma S,Ghanwatkar Y,Vaidya B,Mara D,Cucullo L,Abbruscato TJ
34-1600 was used in Western Blotting to suggest that JUUL exposure could negatively impact the cerebrovascular system, although to a lesser extent than TS exposure.
Fri Sep 09 00:00:00 EDT 2022
Overexpression of Mitochondrial Ferritin Enhances Blood-Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells.
Antioxidants (Basel, Switzerland)
Wang P,Ren Q,Shi M,Liu Y,Bai H,Chang YZ
34-1600 was used in Western Blotting to identify a previously unexplored effect for FtMt in the BBB and provide evidence that iron-mediated oxidative stress in BMVECs is an early cause of BMVECs damage and BBB breakdown in ischemic stroke.
Sun Jun 26 00:00:00 EDT 2022
Overexpression of Mitochondrial Ferritin Enhances Blood-Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells.
Antioxidants (Basel, Switzerland)
Wang P,Ren Q,Shi M,Liu Y,Bai H,Chang YZ
34-1600 was used in Western Blotting to identify a previously unexplored effect for FtMt in the BBB and provide evidence that iron-mediated oxidative stress in BMVECs is an early cause of BMVECs damage and BBB breakdown in ischemic stroke.
Sun Jun 26 00:00:00 EDT 2022
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.
Cell stem cell
Manian KV,Galloway CA,Dalvi S,Emanuel AA,Mereness JA,Black W,Winschel L,Soto C,Li Y,Song Y,DeMaria W,Kumar A,Slukvin I,Schwartz MP,Murphy WL,Anand-Apte B,Chung M,Benoit DSW,Singh R
34-1600 was used in Immunohistochemistry to represent that the human 3D model described here provides a platform for investigating RPE-CC biology, AMD/MD pathophysiology, and testing new therapeutic interventions.
Thu May 06 00:00:00 EDT 2021
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation.
Developmental cell
Zarkada G,Howard JP,Xiao X,Park H,Bizou M,Leclerc S,Künzel SE,Boisseau B,Li J,Cagnone G,Joyal JS,Andelfinger G,Eichmann A,Dubrac A
34-1600 was used in Immunohistochemistry to show that diving tip cells invading the mouse neuroretina (D-tip cells) are distinct from tip cells guiding the superficial retinal vascular plexus (S-tip cells).
Mon Aug 09 00:00:00 EDT 2021
Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.
Cardiovascular research
Hollier PL,Chapouly C,Diop A,Guimbal S,Cornuault L,Gadeau AP,Renault MA
34-1600 was used in Immunocytochemistry to demonstrate that ectopically administered N-terminal Sonic Hedgehog (N-Shh) and endogenous endothelial-derived Desert Hedgehog (Dhh) induce opposite effects in endothelial cells (ECs).
Mon Nov 01 00:00:00 EDT 2021
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke.
Molecular therapy. Nucleic acids
Wang C,Dong J,Sun J,Huang S,Wu F,Zhang X,Pang D,Fu Y,Li L
34-1600 was used in Western Blot to evaluate the impact of long non-coding RNA X-inactive-specific transcript in acute cerebral ischemic stroke patients, middle cerebral artery occlusion mice, and oxygen-glucose deprivation and restoration brain endothelial cells.
Fri Dec 03 00:00:00 EST 2021
A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability.
Science signaling
Maier-Begandt D,Comstra HS,Molina SA,Krüger N,Ruddiman CA,Chen YL,Chen X,Biwer LA,Johnstone SR,Lohman AW,Good ME,DeLalio LJ,Hong K,Bacon HM,Yan Z,Sonkusare SK,Koval M,Isakson BE
34-1600 was used in Immunohistochemistry to provide a targetable pathway with the potential to promote vein barrier function and prevent the deleterious effects of vascular leak in response to inflammation.
Tue Mar 02 00:00:00 EST 2021
Tumor necrosis factor-induced ArhGEF10 selectively activates RhoB contributing to human microvascular endothelial cell tight junction disruption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Khan A,Ni W,Lopez-Giraldez F,Kluger MS,Pober JS,Pierce RW
34-1600 was used in Immunocytochemistry-immunoflourescence to conclude ArhGEF10 is a TNF-induced RhoB-selective GEF that mediates TJ disruption and barrier loss in human capillary endothelial cells.
Tue Jun 01 00:00:00 EDT 2021
Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export.
International immunology
Nagatake T,Zhao YC,Ito T,Itoh M,Kometani K,Furuse M,Saika A,Node E,Kunisawa J,Minato N,Hamazaki Y
34-1600 was used in Immunohistochemistry to examine claudin expression in thymic endothelial cells to clarify a mechanism ensuring low permeability and high leakiness in cortical and medullary blood vessels.
Mon Mar 01 00:00:00 EST 2021
Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury.
Neuromolecular medicine
Koh SS,Ooi SC,Lui NM,Qiong C,Ho LT,Cheah IK,Halliwell B,Herr DR,Ong WY
34-1600 was used in Immunocytochemistry to elucidate the effect of Ergothioneine on the hCMEC/D3 human brain endothelial cell line.
Mon Mar 01 00:00:00 EST 2021
Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma.
Scientific reports
Zhou Q,Vega Leonel JCM,Santoso MR,Wilson C,van den Berg NS,Chan CT,Aryal M,Vogel H,Cayrol R,Mandella MJ,Schonig F,Lu G,Gambhir SS,Moseley ME,Rosenthal EL,Grant GA
34-1600 was used in Immunohistochemistry to assess the feasibility of detecting HGG using near-infrared fluorescent antibody targeting EGFR.
Thu Mar 11 00:00:00 EST 2021
Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues.
International journal of molecular sciences
Desmarais F,Hervé V,Bergeron KF,Ravaut G,Perrotte M,Fyfe-Desmarais G,Rassart E,Ramassamy C,Mounier C
34-1600 was used in Immunocytochemistry to determine if cerebral ApoD can reach the circulation and accumulate in peripheral tissues.
Fri Apr 16 00:00:00 EDT 2021
Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas.
Acta neuropathologica communications
Wei X,Meel MH,Breur M,Bugiani M,Hulleman E,Phoenix TN
34-1600 was used in Immunohistochemistry to characterise and directly compare tumor-associated vasculature in cortical pediatric high-grade gliomas and diffuse midline gliomas.
Mon Aug 23 00:00:00 EDT 2021
Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq.
Diabetes
Wang Y,Niu A,Pan Y,Cao S,Terker AS,Wang S,Fan X,Toth CL,Ramirez Solano MA,Michell DL,Contreras D,Allen RM,Zhu W,Sheng Q,Fogo AB,Vickers KC,Zhang MZ,Harris RC
34-1600 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to study the podocyte translatome in T2DN in podocin-Cre; Rosa26fsTRAP; eNOS-/-; db/db mice and compared it with that of streptozotocin-induced T1DN in podocin-Cre; Rosa26fsTRAP; eNOS-/- mice using translating ribosome affinity purification (TRAP) and RNA-seq.
Fri Oct 01 00:00:00 EDT 2021
Brain endothelial LRP1 maintains blood-brain barrier integrity.
Fluids and barriers of the CNS
Storck SE,Kurtyka M,Pietrzik CU
34-1600 was used in Immunocytochemistry to supplement previous results and show that brain endothelial Lrp1 ablation results in protease-mediated tight junction degradation, P-glycoprotein (P-gp) reduction and a loss of BBB integrity.
Sat Jun 19 00:00:00 EDT 2021
Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.
Cell reports
Nanou A,Bourbouli M,Vetrano S,Schaeper U,Ley S,Kollias G
34-1600 was used in Western Blot to investigate in vivo the role of Tumor progression locus 2 (Tpl2), a mitogen-activated protein kinase kinase kinase (MAP3K) member with pleiotropic effects in inflammation and cancer.
Tue May 25 00:00:00 EDT 2021
Nano-scale architecture of blood-brain barrier tight-junctions.
eLife
Sasson E,Anzi S,Bell B,Yakovian O,Zorsky M,Deutsch U,Engelhardt B,Sherman E,Vatine G,Dzikowski R,Ben-Zvi A
34-1600 was used in Immunohistochemistry to provide a unique perspective of BBB TJs and open new directions for understanding TJ functionality in biological barriers, ultimately enabling restoration in disease or modulation for drug delivery.
Fri Dec 24 00:00:00 EST 2021
Whole-mount Immunohistochemistry to Visualize Mouse Embryonic Dermal Lymphatic Vasculature.
Bio-protocol
Geng X,Srinivasan SR
34-1600 was used in ELISA, Immunocytochemistry, Western Blot, Sample Prep to present an approach that we have developed to permeabilize, immunolabel, clear, and visualize the lymphatic vessels.
Wed Oct 20 00:00:00 EDT 2021
Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection.
Journal of neuroinflammation
Torices S,Cabrera R,Stangis M,Naranjo O,Fattakhov N,Teglas T,Adesse D,Toborek M
34-1600 was used in Western Blot to analyse the expression pattern of the main SARS-CoV-2 receptors in naïve and HIV-1-infected cells of the neurovascular unit in order to elucidate a possible pathway of the virus entry into the brain and a potential modulatory impact of HIV-1 in this process.
Thu Jul 29 00:00:00 EDT 2021
Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern.
Communications biology
Tabariès S,Annis MG,Lazaris A,Petrillo SK,Huxham J,Abdellatif A,Palmieri V,Chabot J,Johnson RM,Van Laere S,Verhoef C,Hachem Y,Yumeen S,Meti N,Omeroglu A,Altinel G,Gao ZH,Yu ASL,Grünhagen DJ,Vermeulen P,Metrakos P,Siegel PM
34-1600 was used in Immunohistochemistry to provide evidence that Claudin-2 status in patient-derived extracellular vesicles may serve as a relevant prognostic biomarker to predict whether colorectal cancer patients have developed replacement type liver metastases.
Wed Jun 02 00:00:00 EDT 2021
Structural disruption of the blood-brain barrier in repetitive primary blast injury.
Fluids and barriers of the CNS
Uzunalli G,Herr S,Dieterly AM,Shi R,Lyle LT
34-1600 was used in Immunohistochemistry to provide analysis of the blood-brain barrier components after repetitive blast injury.
Thu Jan 07 00:00:00 EST 2021
Attenuated CSF-1R signalling drives cerebrovascular pathology.
EMBO molecular medicine
Delaney C,Farrell M,Doherty CP,Brennan K,O'Keeffe E,Greene C,Byrne K,Kelly E,Birmingham N,Hickey P,Cronin S,Savvides SN,Doyle SL,Campbell M
34-1600 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to suggest a targeted approach to restoring BBB integrity while also restoring CSF-1R signalling in macrophages could drive a therapeutic response in ALSP patients and other AD-like dementia.
Fri Feb 05 00:00:00 EST 2021
Antimicrobial immunity impedes CNS vascular repair following brain injury.
Nature immunology
Mastorakos P,Russo MV,Zhou T,Johnson K,McGavern DB
34-1600 was used in ELISA, Immunocytochemistry, Western Blot, Immunohistochemistry to reveal a common immunological mechanism by which systemic infections deviate reparative programming after central nervous system injury and offer a new therapeutic target to improve recovery.
Fri Oct 01 00:00:00 EDT 2021
Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction.
American journal of physiology. Heart and circulatory physiology
Liu Y,Zhang H,Wang S,Guo Y,Fang X,Zheng B,Gao W,Yu H,Chen Z,Roman RJ,Fan F
34-1600 was used in Western Blotting to suggest our previous findings that the impaired cerebral hemodynamics, BBB leakage, and cognitive impairments in old DM model are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction.
Mon Feb 01 00:00:00 EST 2021
Pathology of the neurovascular unit in leukodystrophies.
Acta neuropathologica communications
Zarekiani P,Breur M,Wolf NI,de Vries HE,van der Knaap MS,Bugiani M
34-1600 was used in Immunohistochemistry (Paraffin) to provide further evidence for dysfunction in the orchestration of the neurovascular unit in leukodystrophies and contribute to a better understanding of the underlying disease mechanism.
Thu Jun 03 00:00:00 EDT 2021
Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound.
Toxicology in vitro : an international journal published in association with BIBRA
Wellens S,Dehouck L,Chandrasekaran V,Singh P,Loiola RA,Sevin E,Exner T,Jennings P,Gosselet F,Culot M
34-1600 was used in Immunocytochemistry-immunofluorescence to study the use of a induced pluripotent stem cell (iPSC)-derived blood-brain barrier (BBB) model to assess the effects of repeated dose treatment with chemicals, using Cyclosporine A (CsA) as a model compound which could be used to allow personalized and patient specific studies in the future.
Tue Jun 01 00:00:00 EDT 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
34-1600 was used in Immunocytochemistry to show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells.
Mon Jul 05 00:00:00 EDT 2021
Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport.
Neuro-oncology advances
Spieth L,Berghoff SA,Stumpf SK,Winchenbach J,Michaelis T,Watanabe T,Gerndt N,Düking T,Hofer S,Ruhwedel T,Shaib AH,Willig K,Kronenberg K,Karst U,Frahm J,Rhee JS,Minguet S,Möbius W,Kruse N,von der Brelie C,Michels P,Stadelmann C,Hülper P,Saher G
34-1600 was used in Immunohistochemistry-immunofluorescence to investigate whether isoflurane can be utilized for therapeutic drug delivery.Barrier function in primary endothelial cells was evaluated by transepithelial/transendothelial electrical resistance, and nanoscale STED and SRRF microscopy.
Wed Apr 27 00:00:00 EDT 2022
Caveolae in CNS arterioles mediate neurovascular coupling.
Nature
Chow BW,Nuñez V,Kaplan L,Granger AJ,Bistrong K,Zucker HL,Kumar P,Sabatini BL,Gu C
34-1600 was used in Immunohistochemistry (Frozen) to find that arteriolar endothelial cells (aECs) have an active role in mediating neurovascular coupling, using two-photon microscopy to image neural activity and vascular dynamics simultaneously in the barrel cortex of awake mice under whisker stimulation.
Sun Mar 01 00:00:00 EST 2020
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids.
Cell stem cell
Pellegrini L,Albecka A,Mallery DL,Kellner MJ,Paul D,Carter AP,James LC,Lancaster MA
34-1600 was used in Immunohistochemistry-immunofluorescence to show that infection with SARS-CoV-2 damages the choroid plexus epithelium, leading to leakage across this important barrier that normally prevents entry of pathogens, immune cells, and cytokines into cerebrospinal fluid and the brain.
Thu Dec 03 00:00:00 EST 2020
Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid.
Frontiers in molecular neuroscience
Spampinato SF,Merlo S,Fagone E,Fruciano M,Sano Y,Kanda T,Sortino MA
34-1600 was used in Western Blotting sorting to show reciprocal crosstalk between infiltrating peripheral cells and astrocytes upon Aβ exposure.
Mon Sep 28 00:00:00 EDT 2020
Herpes Simplex Virus 1-Induced Blood-Brain Barrier Damage Involves Apoptosis Associated With GM130-Mediated Golgi Stress.
Frontiers in molecular neuroscience
He Q,Liu H,Huang C,Wang R,Luo M,Lu W
34-1600 was used in Immunocytochemistry to reveal an association between the GA and the BBB during HSV-1 infection and identify potentially novel targets for protecting the BBB and therapeutic approaches for patients with HSE.
Mon Sep 28 00:00:00 EDT 2020
Herpes Simplex Virus 1-Induced Blood-Brain Barrier Damage Involves Apoptosis Associated With GM130-Mediated Golgi Stress.
Frontiers in molecular neuroscience
He Q,Liu H,Huang C,Wang R,Luo M,Lu W
34-1600 was used in Immunocytochemistry to reveal an association between the GA and the BBB during HSV-1 infection and identify potentially novel targets for protecting the BBB and therapeutic approaches for patients with HSE.
Mon Sep 28 00:00:00 EDT 2020
Transplantation of iPS-derived vascular endothelial cells improves white matter ischemic damage.
Journal of neurochemistry
Xu B,Kurachi M,Shimauchi-Ohtaki H,Yoshimoto Y,Ishizaki Y
34-1600 was used in Immunohistochemistry (PFA fixed) to suggest that internal vascular endothelial cell transplantation can be used to treat demyelination and brain dysfunction cause by white matter infarct.
Mon Jun 01 00:00:00 EDT 2020
Sitagliptin and the Blood-Retina Barrier: Effects on Retinal Endothelial Cells Manifested Only after Prolonged Exposure.
Journal of diabetes research
Jäckle A,Ziemssen F,Kuhn EM,Kampmeier J,Lang GK,Lang GE,Deissler H,Deissler HL
34-1600 was used in Immunocytochemistry to evaluate the effects of DPP-4 inhibitors on retinal endothelial cell barrier stability using immortalized endothelial cells of the bovine retina.
Mon Apr 05 00:00:00 EDT 2021
Sitagliptin and the Blood-Retina Barrier: Effects on Retinal Endothelial Cells Manifested Only after Prolonged Exposure.
Journal of diabetes research
Jäckle A,Ziemssen F,Kuhn EM,Kampmeier J,Lang GK,Lang GE,Deissler H,Deissler HL
34-1600 was used in Immunocytochemistry to evaluate the effects of DPP-4 inhibitors on retinal endothelial cell barrier stability using immortalized endothelial cells of the bovine retina.
Mon Apr 05 00:00:00 EDT 2021
Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction.
Frontiers in physiology
Brunner N,Stein L,Cornelius V,Knittel R,Fallier-Becker P,Amasheh S
34-1600 was used in Western Blotting to test a new screening approach for barrier effectors, exemplarily, this 2-cell model of oocytes was used to analyze the effect of the absorption enhancer sodium caprate on the oocyte pairs.
Mon Sep 28 00:00:00 EDT 2020
Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis.
PloS one
Peroutka RJ,Buzza MS,Mukhopadhyay S,Johnson TA,Driesbaugh KH,Antalis TM
34-1600 was used in Immunohistochemistry to identify testisin as a novel regulator of VE-cadherin adhesions during angiogenesis and indicate a potential new target for regulating neovascular integrity and associated pathologies.
Fri Aug 28 00:00:00 EDT 2020
Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood-Brain Barrier in vivo and in vitro.
Frontiers in physiology
Burek M,Burmester S,Salvador E,Möller-Ehrlich K,Schneider R,Roewer N,Nagai M,Förster CY
34-1600 was used in Western Blotting to creat an in vitro co-culture model based on human kidney cells of the proximal tubule (HK-2) and brain microvascular endothelial cells (BMEC) and use it to study the cellular mechanism of kidney and brain crosstalk in renal ischemia/reperfusion injury.
Sun Nov 12 00:00:00 EST 2023
Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways.
Frontiers in physiology
Vion AC,Perovic T,Petit C,Hollfinger I,Bartels-Klein E,Frampton E,Gordon E,Claesson-Welsh L,Gerhardt H
34-1600 was used in Western Blot to show using flow-induced shear stress and VEGF-A treatment on endothelial cells in vitro, that the response to the magnitude of a mechanical stimulus is influenced by the concentration of a chemical stimulus, and vice versa.
Sat Mar 20 00:00:00 EDT 2021
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
International journal of molecular sciences
Markov AG,Fedorova AA,Kravtsova VV,Bikmurzina AE,Okorokova LS,Matchkov VV,Cornelius V,Amasheh S,Krivoi II
34-1600 was used in Western Blotting to confirm that circulating ouabain can functionally and tissue-specifically affect barrier properties of epithelial and endothelial tissues via Na,K-ATPase-mediated modulation of claudins expression.
Fri Jul 17 00:00:00 EDT 2020
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
International journal of molecular sciences
Markov AG,Fedorova AA,Kravtsova VV,Bikmurzina AE,Okorokova LS,Matchkov VV,Cornelius V,Amasheh S,Krivoi II
34-1600 was used in Western Blotting to confirm that circulating ouabain can functionally and tissue-specifically affect barrier properties of epithelial and endothelial tissues via Na,K-ATPase-mediated modulation of claudins expression.
Fri Jul 17 00:00:00 EDT 2020
S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling.
JCI insight
Geng X,Yanagida K,Akwii RG,Choi D,Chen L,Ho Y,Cha B,Mahamud MR,Berman de Ruiz K,Ichise H,Chen H,Wythe JD,Mikelis CM,Hla T,Srinivasan RS
34-1600 was used in Immunohistochemistry to show that the canonical tip cell marker Delta-like 4 (DLL4) promotes sprouting lymphangiogenesis by enhancing VEGF-C/VEGF receptor 3 (VEGFR3) signaling.
Thu Jul 23 00:00:00 EDT 2020
Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance.
Scientific reports
Roudnicky F,Kim BK,Lan Y,Schmucki R,Küppers V,Christensen K,Graf M,Patsch C,Burcin M,Meyer CA,Westenskow PD,Cowan CA
34-1600 was used in Immunocytochemistry to predict TFs that induce high-resistance barrier properties of ECs as in the BBB.
Tue Mar 03 00:00:00 EST 2020
Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability.
The Journal of biological chemistry
Díaz-Coránguez M,Lin CM,Liebner S,Antonetti DA
34-1600 was used in Immunocytochemistry to suggest that VEGF simultaneously induces vascular permeability and promotes responsiveness to norrin.
Fri Apr 03 00:00:00 EDT 2020
Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders.
Translational psychiatry
Greene C,Hanley N,Campbell M
34-1600 was used in Immunohistochemistry to show that endothelial associated tight junction components are differentially regulated at the blood-brain barrier (BBB) in distinct neuroanatomic regions of human donor brain tissues.
Mon Nov 02 00:00:00 EST 2020
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
eLife
Frye M,Stritt S,Ortsäter H,Hernandez Vasquez M,Kaakinen M,Vicente A,Wiseman J,Eklund L,Martínez-Torrecuadrada JL,Vestweber D,Mäkinen T
34-1600 was used in Immunohistochemistry-immunofluorescence to identify the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity.
Tue Sep 08 00:00:00 EDT 2020
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
eLife
Frye M,Stritt S,Ortsäter H,Hernandez Vasquez M,Kaakinen M,Vicente A,Wiseman J,Eklund L,Martínez-Torrecuadrada JL,Vestweber D,Mäkinen T
34-1600 was used in Immunohistochemistry-immunofluorescence to identify the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity.
Tue Sep 08 00:00:00 EDT 2020
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke.
Journal of neuroinflammation
Zhang X,Wang L,Han Z,Dong J,Pang D,Fu Y,Li L
34-1600 was used in Western Blotting to examine the correlation between serum levels of CAMs/KLF4 and infarct volume in acute CIS patients.
Tue Apr 07 00:00:00 EDT 2020
Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier.
mBio
Clé M,Desmetz C,Barthelemy J,Martin MF,Constant O,Maarifi G,Foulongne V,Bolloré K,Glasson Y,De Bock F,Blaquiere M,Dehouck L,Pirot N,Tuaillon E,Nisole S,Najioullah F,Van de Perre P,Cabié A,Marchi N,Gosselet F,Simonin Y,Salinas S
34-1600 was used in Immunocytochemistry-immunoflourescence to suggest a complex interplay between ZIKV and the BBB, which may trigger local inflammation, leukocyte recruitment, and possible cerebral vasculature impairment.
Tue Aug 04 00:00:00 EDT 2020
Development of a human in vitro blood-brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance.
Fluids and barriers of the CNS
Deligne C,Hachani J,Duban-Deweer S,Meignan S,Leblond P,Carcaboso AM,Sano Y,Shimizu F,Kanda T,Gosselet F,Dehouck MP,Mysiorek C
34-1600 was used in Immunocytochemistry to develop a syngeneic human blood-brain tumor barrier model to understand how the presence of diffuse intrinsic pontine glioma(DIPG) impacts the structure and function of brain capillary endothelial cells.
Tue Jun 02 00:00:00 EDT 2020
NIR-II window tracking of hyperglycemia induced intracerebral hemorrhage in cerebral cavernous malformation deficient mice.
Biomaterials science
Parchur AK,Fang Z,Jagtap JM,Sharma G,Hansen C,Shafiee S,Hu W,Miao QR,Joshi A
34-1600 was used in Immunohistochemistry to validate that deep-penetrating NIR-II QDs can be used for the tracking of ICH and BBB hyperpermeability in transgenic mice models of cerebral vascular anomalies.
Mon Sep 21 00:00:00 EDT 2020
CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation.
Journal of neuroinflammation
Kim Y,Lee S,Zhang H,Lee S,Kim H,Kim Y,Won MH,Kim YM,Kwon YG
34-1600 was used in Western Blot to suggest that activation of VEGFR-2 in CLEC14A-KO mice aggravates ischemic stroke by exacerbating cerebral vascular leakage and increasing neuronal inflammation after ischemia-reperfusion injury.
Tue Feb 04 00:00:00 EST 2020
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Acta neuropathologica communications
Duarte Lobo D,Nobre RJ,Oliveira Miranda C,Pereira D,Castelhano J,Sereno J,Koeppen A,Castelo-Branco M,Pereira de Almeida L
34-1600 was used in Western Blotting to demonstrate that blood-brain barrier (BBB) impairment in Machado-Joseph disease/SCA type 3 (MJD/SCA3).
Mon Aug 31 00:00:00 EDT 2020
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module.
Nature neuroscience
Munji RN,Soung AL,Weiner GA,Sohet F,Semple BD,Trivedi A,Gimlin K,Kotoda M,Korai M,Aydin S,Batugal A,Cabangcala AC,Schupp PG,Oldham MC,Hashimoto T,Noble-Haeusslein LJ,Daneman R
34-1600 was used in Immunohistochemistry to analyse the gene expression of endothelial cells in mice, comparing brain endothelial cells with peripheral endothelial cells.
Fri Nov 01 00:00:00 EDT 2019
Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.
British journal of anaesthesia
Yang T,Xu G,Newton PT,Chagin AS,Mkrtchian S,Carlström M,Zhang XM,Harris RA,Cooter M,Berger M,Maddipati KR,Akassoglou K,Terrando N
34-1600 was used in Immunohistochemistry to show MaR1 exerts distinct anti-inflammatory and pro-resolving effects through regulation of macrophage infiltration, NF-κB signalling, and cytokine release after surgery.
Fri Mar 01 00:00:00 EST 2019
Plasminogen activator inhibitor-1 augments damage by impairing fibrinolysis after traumatic brain injury.
Annals of neurology
Griemert EV,Schwarzmaier SM,Hummel R,Gölz C,Yang D,Neuhaus W,Burek M,Förster CY,Petkovic I,Trabold R,Plesnila N,Engelhard K,Schäfer MK,Thal SC
34-1600 was used in Immunohistochemistry-immunofluorescence to identify impaired fibrinolysis as a critical process in post-traumatic secondary brain damage and suggest that PAI-1 may be a central endogenous inhibitor of the fibrinolytic pathway, promoting a procoagulatory state and clot formation in the cerebral microvasculature.
Wed May 01 00:00:00 EDT 2019
Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling.
Arteriosclerosis, thrombosis, and vascular biology
Jensen LD,Hot B,Ramsköld D,Germano RFV,Yokota C,Giatrellis S,Lauschke VM,Hubmacher D,Li MX,Hupe M,Arnold TD,Sandberg R,Frisén J,Trusohamn M,Martowicz A,Wisniewska-Kruk J,Nyqvist D,Adams RH,Apte SS,Vanhollebeke B,Stenman JM,Kele J
34-1600 was used in Immunohistochemistry to suggest a novel mechanism of establishing a central nervous system (CNS) endothelium-specific ECM (extracellular matrix) signature downstream of Wnt-β-catenin that impact spatiotemporally on blood-brain barrier differentiation during forebrain vessel development.
Mon Jul 01 00:00:00 EDT 2019
Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function.
Stroke
Bieber M,Schuhmann MK,Volz J,Kumar GJ,Vaidya JR,Nieswandt B,Pham M,Stoll G,Kleinschnitz C,Kraft P
34-1600 was used in Immunohistochemistry to characterize a prototypic member of this class of novel PDE-3 inhibitors (substance V) about safety and efficacy and to delineate the underlying in vivo mechanisms in a mouse model of brain ischemia/reperfusion injury.
Fri Feb 01 00:00:00 EST 2019
Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.
The Journal of cell biology
Nakamura K,Ikeuchi T,Nara K,Rhodes CS,Zhang P,Chiba Y,Kazuno S,Miura Y,Ago T,Arikawa-Hirasawa E,Mukouyama YS,Yamada Y
34-1600 was used in Immunohistochemistry-immunofluorescence to show that perlecan aids in blood-brain barrier (BBB) maintenance and repair through pericyte interactions.
Mon Oct 07 00:00:00 EDT 2019
Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.
The Journal of cell biology
Nakamura K,Ikeuchi T,Nara K,Rhodes CS,Zhang P,Chiba Y,Kazuno S,Miura Y,Ago T,Arikawa-Hirasawa E,Mukouyama YS,Yamada Y
34-1600 was used in Immunohistochemistry-immunofluorescence to show that perlecan aids in blood-brain barrier (BBB) maintenance and repair through pericyte interactions.
Mon Oct 07 00:00:00 EDT 2019
EP4 Antagonist-Elicited Extracellular Vesicles from Mesenchymal Stem Cells Rescue Cognition/Learning Deficiencies by Restoring Brain Cellular Functions.
Stem cells translational medicine
Chen SY,Lin MC,Tsai JS,He PL,Luo WT,Herschman H,Li HJ
34-1600 was used in Immunohistochemistry-immunofluorescence to find that blocking the prostaglandin E2 /prostaglandin E2 receptor 4 (PGE2 /EP4 ) signaling pathway in MSCs with EP4 antagonists increased EV release and promoted the sorting of specific proteins, including anti-inflammatory cytokines and factors that modify astrocyte function, blood-brain barrier integrity, and microglial migration into the damaged hippocampus, into the EVs.
Mon Jul 01 00:00:00 EDT 2019
GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.
Development (Cambridge, England)
Mahamud MR,Geng X,Ho YC,Cha B,Kim Y,Ma J,Chen L,Myers G,Camper S,Mustacich D,Witte M,Choi D,Hong YK,Chen H,Varshney G,Engel JD,Wang S,Kim TH,Lim KC,Srinivasan RS
34-1600 was used in Immunohistochemistry to define a new mechanism of GATA2 activity and uncover miR-126 as a novel regulator of mammalian lymphatic vascular development.
Tue Nov 05 00:00:00 EST 2019
Expression patterns of endothelial permeability pathways in the development of the blood-retinal barrier in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van der Wijk AE,Wisniewska-Kruk J,Vogels IMC,van Veen HA,Ip WF,van der Wel NN,van Noorden CJF,Schlingemann RO,Klaassen I
34-1600 was used in Immunohistochemistry-immunofluorescence to describe in detail the formation of the blood-retinal-barrier (BRB) at the molecular level in physiologic conditions, using mice from postnatal day (P)3 to P25.
Mon Apr 01 00:00:00 EDT 2019
The role of LINC00094/miR-224-5p (miR-497-5p)/Endophilin-1 axis in Memantine mediated protective effects on blood-brain barrier in AD microenvironment.
Journal of cellular and molecular medicine
Zhu L,Lin M,Ma J,Liu W,Gao L,Wei S,Xue Y,Shang X
34-1600 was used in Western Blotting to demonstrate the role of the memantine in regulating blood-brain barrier permeability in Alzheimer's disease microenvironment as well as its possible mechanisms.
Wed May 01 00:00:00 EDT 2019
Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Deissler HL,Lang GK,Lang GE
34-1600 was used in Western Blot to study aflibercept's associations with proteins either involved in neonatal Fc receptor-mediated transport or in the lysosomal pathway.
Tue Jan 01 00:00:00 EST 2019
Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model.
Frontiers in cellular neuroscience
Spampinato SF,Merlo S,Fagone E,Fruciano M,Barbagallo C,Kanda T,Sano Y,Purrello M,Vancheri C,Ragusa M,Sortino MA
34-1600 was used in Western Blotting to identify that astrocytes play a role in the modulation of leukocytes migration through the endothelial layers in the early phases of β-Amyloid exposure.
Sat Apr 09 00:00:00 EDT 2022
Claudin-12 is not required for blood-brain barrier tight junction function.
Fluids and barriers of the CNS
Castro Dias M,Coisne C,Baden P,Enzmann G,Garrett L,Becker L,Hölter SM,Hrabě de Angelis M,Deutsch U,Engelhardt B
34-1600 was used in Western Blotting to study the role and localisation of claudin-12.
Thu Sep 12 00:00:00 EDT 2019
Japanese encephalitis virus neuropenetrance is driven by mast cell chymase.
Nature communications
Hsieh JT,Rathore APS,Soundarajan G,St John AL
34-1600 was used in Western Blotting to study the mechanisms of Japanese encephalitis at the blood brain barrier.
Mon Feb 11 00:00:00 EST 2019
Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy.
Nature communications
Park H,Yamamoto H,Mohn L,Ambühl L,Kanai K,Schmidt I,Kim KP,Fraccaroli A,Feil S,Junge HJ,Montanez E,Berger W,Adams RH
34-1600 was used in Immunohistochemistry to suggest that defective cell-matrix interactions are linked to Wnt signaling and FEVR.
Wed Nov 20 00:00:00 EST 2019
Leptin receptor deficiency induces early, transient and hyperglycaemia-independent blood-brain barrier dysfunction.
Scientific reports
Corem N,Anzi S,Gelb S,Ben-Zvi A
34-1600 was used in Immunohistochemistry-immunofluorescence to determine the integrity of brain capillaries and blood-brain barrier permeability in diabetes.
Wed Feb 27 00:00:00 EST 2019
Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation.
Nature communications
Weiner GA,Shah SH,Angelopoulos CM,Bartakova AB,Pulido RS,Murphy A,Nudleman E,Daneman R,Goldberg JL
34-1600 was used in Immunohistochemistry to study cholinergic neural activity in central nervous system development.
Thu Jun 06 00:00:00 EDT 2019
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy.
JCI insight
Hudson N,Celkova L,Hopkins A,Greene C,Storti F,Ozaki E,Fahey E,Theodoropoulou S,Kenna PF,Humphries MM,Curtis AM,Demmons E,Browne A,Liddie S,Lawrence MS,Grimm C,Cahill MT,Humphries P,Doyle SL,Campbell M
34-1600 was used in Western Blotting to implicate an inner retina-derived component in the early pathophysiological changes observed in AMD, and suggest that restoring the integrity of the inner blood-retina barrier may represent a novel therapeutic target.
Thu Aug 08 00:00:00 EDT 2019
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy.
JCI insight
Hudson N,Celkova L,Hopkins A,Greene C,Storti F,Ozaki E,Fahey E,Theodoropoulou S,Kenna PF,Humphries MM,Curtis AM,Demmons E,Browne A,Liddie S,Lawrence MS,Grimm C,Cahill MT,Humphries P,Doyle SL,Campbell M
34-1600 was used in Western Blotting to implicate an inner retina-derived component in the early pathophysiological changes observed in AMD, and suggest that restoring the integrity of the inner blood-retina barrier may represent a novel therapeutic target.
Thu Aug 08 00:00:00 EDT 2019
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy.
JCI insight
Hudson N,Celkova L,Hopkins A,Greene C,Storti F,Ozaki E,Fahey E,Theodoropoulou S,Kenna PF,Humphries MM,Curtis AM,Demmons E,Browne A,Liddie S,Lawrence MS,Grimm C,Cahill MT,Humphries P,Doyle SL,Campbell M
34-1600 was used in Western Blotting to implicate an inner retina-derived component in the early pathophysiological changes observed in AMD, and suggest that restoring the integrity of the inner blood-retina barrier may represent a novel therapeutic target.
Thu Aug 08 00:00:00 EDT 2019
Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood-retinal barrier.
Acta ophthalmologica
van der Wijk AE,Canning P,van Heijningen RP,Vogels IMC,van Noorden CJF,Klaassen I,Schlingemann RO
34-1600 was used in Immunocytochemistry to investigate whether TA was able to prevent barrier disruption after stimulation with VEGF or cytokines.
Fri Mar 01 00:00:00 EST 2019
β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Izawa Y,Gu YH,Osada T,Kanazawa M,Hawkins BT,Koziol JA,Papayannopoulou T,Spatz M,Del Zoppo GJ
34-1600 was used in Immunohistochemistry-immunofluorescence to study how interruptions to β1-integrin-matrix adhesion lead to increased permeability in the the blood-brain barrier.
Sun Apr 01 00:00:00 EDT 2018
β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Izawa Y,Gu YH,Osada T,Kanazawa M,Hawkins BT,Koziol JA,Papayannopoulou T,Spatz M,Del Zoppo GJ
34-1600 was used in Immunohistochemistry-immunofluorescence to study how interruptions to β1-integrin-matrix adhesion lead to increased permeability in the the blood-brain barrier.
Sun Apr 01 00:00:00 EDT 2018
Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy.
Tissue barriers
Dong C,Helton ES,Zhou P,Ouyang X,d'Anglemont de Tassigny X,Pascual A,López-Barneo J,Ubogu EE
34-1600 was used in Immunohistochemistry-immunofluorescence to demonstrate that glial-derived neurotrophic factor (GDNF) plays an important role in restoring restrictive blood-nerve barrier (BNB) function.
Tue Dec 11 00:00:00 EST 2018
Loss of connexin43 in murine Sertoli cells and its effect on blood-testis barrier formation and dynamics.
PloS one
Hollenbach J,Jung K,Noelke J,Gasse H,Pfarrer C,Koy M,Brehm R
34-1600 was used in Immunohistochemistry to reveal that SCCx43KO-/- mice formed an intact blood-testis barrier during puberty in the same time period as WT mice, which however seemed to be accelerated.
Wed Dec 12 00:00:00 EST 2018
Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events.
Nature communications
Honkura N,Richards M,Laviña B,Sáinz-Jaspeado M,Betsholtz C,Claesson-Welsh L
34-1600 was used in Immunohistochemistry to develop a non-invasive technique to study dynamic events in different vessel categories by multi-photon microscopy and RVDM (relative velocity, direction, and morphology).
Mon Jul 16 00:00:00 EDT 2018
Mechanical load increase-induced changes in cytoskeletal structure and cellular barrier function in human cerebral endothelial cells.
Biotechnology and bioengineering
Kim D,Kwon S
34-1600 was used in Immunocytochemistry-immunofluorescence to indicate that increased mechanical load due to the applied hypergravity affects the cytoskeletal arrangement and tight junctions, thereby weakening the cell barrier function and enhancing the permeability of the paracellular pathway.
Mon Oct 01 00:00:00 EDT 2018
Social stress induces neurovascular pathology promoting depression.
Nature neuroscience
Menard C,Pfau ML,Hodes GE,Kana V,Wang VX,Bouchard S,Takahashi A,Flanigan ME,Aleyasin H,LeClair KB,Janssen WG,Labonté B,Parise EM,Lorsch ZS,Golden SA,Heshmati M,Tamminga C,Turecki G,Campbell M,Fayad ZA,Tang CY,Merad M,Russo SJ
34-1600 was used in Immunohistochemistry to suggest that chronic social stress alters BBB integrity through loss of tight junction protein Cldn5, promoting depression.
Fri Dec 01 00:00:00 EST 2017
VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.
Circulation research
Heinolainen K,Karaman S,D'Amico G,Tammela T,Sormunen R,Eklund L,Alitalo K,Zarkada G
34-1600 was used in Immunohistochemistry to examine vascular endothelial growth factor pathway activity in quiescent and angiogenic blood vascular endothelial cells.
Fri Apr 28 00:00:00 EDT 2017
Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress.
Scientific reports
Mohamed R,Sharma I,Ibrahim AS,Saleh H,Elsherbiny NM,Fulzele S,Elmasry K,Smith SB,Al-Shabrawey M,Tawfik A
34-1600 was used in Western Blotting to suggest activation of oxidative stress as a possible mechanism of hyperhomocysteinemia induced retinal endothelial cell dysfunction.
Wed Sep 20 00:00:00 EDT 2017
Isolation and Cultivation of Primary Brain Endothelial Cells from Adult Mice.
Bio-protocol
Assmann JC,Müller K,Wenzel J,Walther T,Brands J,Thornton P,Allan SM,Schwaninger M
34-1600 was used in Immunocytochemistry to show isolation of adult mice brain endothelial cells.
Sat May 20 00:00:00 EDT 2017
From the Cover: Comparative Proteomics Reveals Silver Nanoparticles Alter Fatty Acid Metabolism and Amyloid Beta Clearance for Neuronal Apoptosis in a Triple Cell Coculture Model of the Blood-Brain Barrier.
Toxicological sciences : an official journal of the Society of Toxicology
Lin HC,Ho MY,Tsen CM,Huang CC,Wu CC,Huang YJ,Hsiao IL,Chuang CY
34-1600 was used in Immunocytochemistry-immunofluorescence to suggest that AgNP exposure might cause Aβ deposition and inflammation for subsequent neuronal cell apoptosis to potentially induce AD progression.
Sat Jul 01 00:00:00 EDT 2017
Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke.
Neurobiology of disease
Zhang Z,Yan J,Shi H
341600 was used in western blot to test if hypoxia inducible factor-1 activation contributes to hyperglycemia-aggravated blood brain barrier disruption in an ischemic stroke model
Tue Nov 01 00:00:00 EDT 2016
Neuroprotective Effects of Poly(ADP-ribose)polymerase Inhibitor Olaparib in Transient Cerebral Ischemia.
Neurochemical research
Teng F,Zhu L,Su J,Zhang X,Li N,Nie Z,Jin L
34-1600 was used in immunohistochemistry - frozen section to study the neuroprotective effects of olaparib, a poly(ADP-ribose) polymerase inhibitor, in transient cerebral ischemia
Fri Jul 01 00:00:00 EDT 2016
MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1.
Experimental cell research
Liu W,Cai H,Lin M,Zhu L,Gao L,Zhong R,Bi S,Xue Y,Shang X
34-1600 was used in immunocytochemistry and western blot to study the prevention of amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1 by MicroRNA-107
Sun May 01 00:00:00 EDT 2016
The role of pericytic laminin in blood brain barrier integrity maintenance.
Scientific reports
Gautam J,Zhang X,Yao Y
341600 was used in immunohistochemistry to examine the function of pericyte-derived laminin in vascular integrity
Thu Nov 03 00:00:00 EDT 2016
Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.
eLife
Bassett EA,Tokarew N,Allemano EA,Mazerolle C,Morin K,Mears AJ,McNeill B,Ringuette R,Campbell C,Smiley S,Pokrajac NT,Dubuc AM,Ramaswamy V,Northcott PA,Remke M,Monnier PP,Potter D,Paes K,Kirkpatrick LL,Coker KJ,Rice DS,Perez-Iratxeta C,Taylor MD,Wallace VA
341600 was used in immunohistochemistry to report the relationship between pre-tumor cells and their surrounding stroma in cerebellar tumor medulloblastoma
Tue Nov 08 00:00:00 EST 2016
Improved Treatment Efficacy of Antiangiogenic Therapy when Combined with Picornavirus Vaccination in the GL261 Glioma Model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Renner DN,Malo CS,Jin F,Parney IF,Pavelko KD,Johnson AJ
34-1600 was used in Immunohistochemistry (PFA fixed) to demonstrate the efficacy of combined antiangiogenic and immunotherapy approaches for treating established gliomas and provides a foundation for further evaluation of the effects of antiangiogenic therapy in the context of endogenous or vaccine-induced inflammatory responses.
Fri Jan 01 00:00:00 EST 2016
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.
PloS one
Huang LY,Stuart C,Takeda K,D'Agnillo F,Golding B
34-1600 was used in western blot assess the effect of polyinosinic-polycytidylic acid on the barrier function and tight junction integrity of primary human lung microvascular endothelial cells
Fri Aug 04 00:00:00 EDT 2017
Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling.
PloS one
Adam AP,Lowery AM,Martino N,Alsaffar H,Vincent PA
34-1600 was used in immunocytochemistry investigate the effects of TNF treatment and SFK activation using human dermal microvascular endothelial cells
Wed Aug 02 00:00:00 EDT 2017
Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.
Nature communications
Szalay G,Martinecz B,Lénárt N,Környei Z,Orsolits B,Judák L,Császár E,Fekete R,West BL,Katona G,Rózsa B,Dénes Á
34-1600 was used in immunohistochemistry - free floating to characterize dysregulation of neuronal network activity following a stroke due to microglia protecting against brain injury and their selective elimination
Tue May 03 00:00:00 EDT 2016
Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity.
The Journal of clinical investigation
Licht T,Dor-Wollman T,Ben-Zvi A,Rothe G,Keshet E
34-1600 was used in immunohistochemistry - paraffin section to evaluate an animal model for periventricular leukomalacia
Mon Mar 02 00:00:00 EST 2015
Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers.
Biomaterials
Staat C,Coisne C,Dabrowski S,Stamatovic SM,Andjelkovic AV,Wolburg H,Engelhardt B,Blasig IE
34-1600 was used in immunocytochemistry to investigate the role of claudin-1/claudin-5 in epithelial/endothelial barriers
Mon Jun 01 00:00:00 EDT 2015
Immune quiescence of the brain is set by astroglial connexin 43.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Boulay AC,Mazeraud A,Cisternino S,Saubaméa B,Mailly P,Jourdren L,Blugeon C,Mignon V,Smirnova M,Cavallo A,Ezan P,Avé P,Dingli F,Loew D,Vieira P,Chrétien F,Cohen-Salmon M
34-1600 was used in western blot to study the role of astroglial cx43 in immune quiescence of the brain
Wed Mar 11 00:00:00 EDT 2015
Roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression.
Journal of neuropathology and experimental neurology
Cai H,Liu W,Xue Y,Shang X,Liu J,Li Z,Wang P,Liu L,Hu Y,Liu Y
34-1600 was used in immunocytochemistry and western blot to study how knockdown of Robo4 alters the blood-tumor barrier.
Thu Jan 01 00:00:00 EST 2015
NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.
Tissue barriers
Ward C,Schlingmann B,Stecenko AA,Guidot DM,Koval M
34-1600 was used in immunohistochemistry to investigate the effect of NF-kappaB inhibitors on lung epithelial tight junctions in the absence of inflammation.
Fri Apr 03 00:00:00 EDT 2015
The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144.
Oncotarget
Cai H,Xue Y,Wang P,Wang Z,Li Z,Hu Y,Li Z,Shang X,Liu Y
34-1600 was used in immunocytochemistry and western blot to determine the role of lncRNAs in blood tumor barrier permeability
Fri Aug 14 00:00:00 EDT 2015
Sera from patients with multifocal motor neuropathy disrupt the blood-nerve barrier.
Journal of neurology, neurosurgery, and psychiatry
Shimizu F,Omoto M,Sano Y,Mastui N,Miyashiro A,Tasaki A,Maeda T,Koga M,Kaji R,Kanda T
Thu May 01 00:00:00 EDT 2014
The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions.
Cell and tissue research
Steiner E,Enzmann GU,Lyck R,Lin S,Rüegg MA,Kröger S,Engelhardt B
34-1600 was used in immunohistochemistry to analyze the barrier properties of mouse brain endothelial cells and stabilizing adherens junctions due to heparan sulfate proteoglycan agrin
Sat Nov 01 00:00:00 EDT 2014
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.
PloS one
Boyer-Di Ponio J,El-Ayoubi F,Glacial F,Ganeshamoorthy K,Driancourt C,Godet M,Perrière N,Guillevic O,Couraud PO,Uzan G
34-1600 was used in immunocytochemistry to study cord blood as a source of circulating endothelial progenitor cells that can be directed towards specialized endothelial phenotypes
Tue Nov 18 00:00:00 EST 2014
Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity.
Nature communications
Yao Y,Chen ZL,Norris EH,Strickland S
34-1600 was used in immunohistochemistry and western blot to find that astrocytic laminin maintains the blood brain barrier by regulating pericyte differentiation.
Mon Mar 03 00:00:00 EST 2014
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies.
Fluids and barriers of the CNS
Morin-Brureau M,De Bock F,Lerner-Natoli M
34-1600 was used in western blot to develop an organotypic brain slice culture as a model to study the role of the neurovascular unit in epilepsy and other neurological disorders.
Thu Feb 07 00:00:00 EST 2013
HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mishra R,Singh SK
34-1600 was used in western blot to demonstrate the effect of HIV-1 Tat C on miRNA-101 expression in human brain microvascular endothelial cells
Wed Apr 03 00:00:00 EDT 2013
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
Experimental neurology
Teng F,Beray-Berthat V,Coqueran B,Lesbats C,Kuntz M,Palmier B,Garraud M,Bedfert C,Slane N,Bérézowski V,Szeremeta F,Hachani J,Scherman D,Plotkine M,Doan BT,Marchand-Leroux C,Margaill I
34-1600 was used in western blot to evaluate the protective effect of the poly(ADP-ribose)polymerase inhibitor PJ34 against vascular toxicity
Tue Oct 01 00:00:00 EDT 2013
Advanced glycation end-products disrupt the blood-brain barrier by stimulating the release of transforming growth factor-β by pericytes and vascular endothelial growth factor and matrix metalloproteinase-2 by endothelial cells in vitro.
Neurobiology of aging
Shimizu F,Sano Y,Tominaga O,Maeda T,Abe MA,Kanda T
34-1600 was used in western blot to identify the mechanisms responsible for the disruption of the blood brain barrier after exposure to advanced glycation end-products.
Mon Jul 01 00:00:00 EDT 2013
Tissue plasminogen activator prevents restoration of tight junction proteins through upregulation of angiopoietin-2.
Current neurovascular research
Mishiro K,Ishiguro M,Suzuki Y,Tsuruma K,Shimazawa M,Hara H
34-1600 was used in western blot to examine tight junction proteins following focal cerebral ischemia/reperfusion.
Fri Feb 01 00:00:00 EST 2013
12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.
The Journal of biological chemistry
Kundumani-Sridharan V,Dyukova E,Hansen DE,Rao GN
34-1600 was used in Immunocytochemistry to understand the mechanisms by which 12/15-LO mediates endothelial dysfunction.
Fri May 31 00:00:00 EDT 2013
HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells.
Cellular and molecular life sciences : CMLS
Yan J,Zhang Z,Shi H
34-1600 was used in western blot to determine the role of hypoxia-inducible factor-1 in high glucose-induced endothelial permeability of the blood brain barrier.
Sun Jan 01 00:00:00 EST 2012
Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Lopez-Ramirez MA,Fischer R,Torres-Badillo CC,Davies HA,Logan K,Pfizenmaier K,Male DK,Sharrack B,Romero IA
34-1600 was used in western blot to study the role of caspases in cytokine-induced barrier breakdown during neuroinflammation
Sat Sep 15 00:00:00 EDT 2012
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Journal of cell science
Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S
Thu Nov 01 00:00:00 EDT 2012
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Journal of cell science
Guillemot L,Schneider Y,Brun P,Castagliuolo I,Pizzuti D,Martines D,Jond L,Bongiovanni M,Citi S
Thu Nov 01 00:00:00 EDT 2012
A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice.
Neuroscience
Mishiro K,Ishiguro M,Suzuki Y,Tsuruma K,Shimazawa M,Hara H
34-1600 was used in western blot to test if inhibition of matrix metalloproteinases protects against hemorrhagic complications induced by tissue plasminogen activator.
Thu Mar 15 00:00:00 EDT 2012
Lung endothelial cells strengthen, but brain endothelial cells weaken barrier properties of a human alveolar epithelium cell culture model.
Differentiation; research in biological diversity
Neuhaus W,Samwer F,Kunzmann S,Muellenbach RM,Wirth M,Speer CP,Roewer N,Förster CY
34-1600 was used in Western Blotting to investigate possible interplay between the alveolar epithelium and the underlying blood compartment cell layers in the blood-air barrier of the lung.
Thu Nov 01 00:00:00 EDT 2012
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Science (New York, N.Y.)
Alvarez JI,Dodelet-Devillers A,Kebir H,Ifergan I,Fabre PJ,Terouz S,Sabbagh M,Wosik K,Bourbonnière L,Bernard M,van Horssen J,de Vries HE,Charron F,Prat A
Fri Dec 23 00:00:00 EST 2011
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Science (New York, N.Y.)
Alvarez JI,Dodelet-Devillers A,Kebir H,Ifergan I,Fabre PJ,Terouz S,Sabbagh M,Wosik K,Bourbonnière L,Bernard M,van Horssen J,de Vries HE,Charron F,Prat A
Fri Dec 23 00:00:00 EST 2011
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Acta neuropathologica
Pfeiffer F,Schäfer J,Lyck R,Makrides V,Brunner S,Schaeren-Wiemers N,Deutsch U,Engelhardt B
34-1600 was used in immunohistochemistry (frozen) to assess the effects of stabilizing the blood brain barrier function by therapeutic targeting tight junction proteins for experimental autoimmune encephalomyelitis.
Tue Nov 01 00:00:00 EDT 2011
Adenosine receptor signaling modulates permeability of the blood-brain barrier.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Carman AJ,Mills JH,Krenz A,Kim DG,Bynoe MS
34-1600 was used in immunocytochemistry to show that adenosine receptor signaling modulates blood brain barrier permeability in vivo.
Wed Sep 14 00:00:00 EDT 2011
Hypoxia increases transepithelial electrical conductance and reduces occludin at the plasma membrane in alveolar epithelial cells via PKC-ζ and PP2A pathway.
American journal of physiology. Lung cellular and molecular physiology
Caraballo JC,Yshii C,Butti ML,Westphal W,Borcherding JA,Allamargot C,Comellas AP
Fri Apr 01 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Identification of claudins by western blot and immunofluorescence in different cell lines and tissues.
Methods in molecular biology (Clifton, N.J.)
González-Mariscal L,Garay E,Quirós M
34-1600 was used in Immunohistochemistry and Western Blotting to describe in detail protocols used for western blot and immunofluorescence detection of claudins in epithelial cell lines and in various tissue samples.
Fri Nov 04 00:00:00 EDT 2011
Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.
The Journal of comparative neurology
Mullier A,Bouret SG,Prevot V,Dehouck B
Thu Apr 01 00:00:00 EDT 2010
Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function.
Biology of reproduction
Morrow CM,Tyagi G,Simon L,Carnes K,Murphy KM,Cooke PS,Hofmann MC,Hess RA
34-1600 was used in immunohistochemistry - paraffin section to study tight junction proteins in Etv5 knockout mice
Sun Nov 01 00:00:00 EDT 2009
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node.
European journal of immunology
Pfeiffer F,Kumar V,Butz S,Vestweber D,Imhof BA,Stein JV,Engelhardt B
34-1600 was used in immunohistochemistry to examine the architecture of cellular junctions present in blood and lymphatic vessel endothelium in peripheral lymph nodes
Fri Aug 01 00:00:00 EDT 2008
Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse.
The Journal of comparative neurology
Benton RL,Maddie MA,Minnillo DR,Hagg T,Whittemore SR
Sat Mar 01 00:00:00 EST 2008
Cadmium causes delayed effects on renal function in the offspring of cadmium-contaminated pregnant female rats.
American journal of physiology. Renal physiology
Jacquillet G,Barbier O,Rubera I,Tauc M,Borderie A,Namorado MC,Martin D,Sierra G,Reyes JL,Poujeol P,Cougnon M
34-1600 was used in immunohistochemistry - frozen section to test if intoxication of pregnant rats has any deleterious effects on the offspring's renal function
Thu Nov 01 00:00:00 EDT 2007
Claudin immunolocalization in neonatal mouse epithelial tissues.
Cell and tissue research
Troy TC,Arabzadeh A,Yerlikaya S,Turksen K
34-1600 was used in immunohistochemistry - paraffin section to analyze the localizations of Cldn1, Cldn6, Cldn11, and Cldn18, and the presence of Cldn3 and Cldn5 in various neonatal mouse epithelia
Thu Nov 01 00:00:00 EDT 2007
Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis.
Neuroscience
Morgan L,Shah B,Rivers LE,Barden L,Groom AJ,Chung R,Higazi D,Desmond H,Smith T,Staddon JM
34-1600 was used in immunohistochemistry - frozen section to analyze lumbar spinal cord proteins present in naive and experimental autoimmune encephalomyelitis rats
Fri Jul 13 00:00:00 EDT 2007
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex.
Histochemistry and cell biology
Anstrom JA,Thore CR,Moody DM,Brown WR
34-1600 was used in immunohistochemistry to test if the expression of tight junction proteins increases in vessels of germinal matrix and cortex with gestational age
Thu Feb 01 00:00:00 EST 2007
Heat-induced antigen retrieval: mechanisms and application to histochemistry.
Progress in histochemistry and cytochemistry
Yamashita S
34-1600 was used in immunohistochemistry - frozen section to review mechanisms and applications of heat-induced antigen retrieval
Tue Mar 13 00:00:00 EDT 2007
Zinc protects renal function during cadmium intoxication in the rat.
American journal of physiology. Renal physiology
Jacquillet G,Barbier O,Cougnon M,Tauc M,Namorado MC,Martin D,Reyes JL,Poujeol P
Sun Jan 01 00:00:00 EST 2006
Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia.
Cell and tissue research
Liévano S,Alarcón L,Chávez-Munguía B,González-Mariscal L
34-1600 was used in immunohistochemistry - frozen section and western blot to examine the molecular composition of the tight junction present in human term placenta from normal women and from those with preeclampsia
Thu Jun 01 00:00:00 EDT 2006
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
American journal of physiology. Heart and circulatory physiology
Brooks TA,Hawkins BT,Huber JD,Egleton RD,Davis TP
Mon Aug 01 00:00:00 EDT 2005
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
American journal of physiology. Heart and circulatory physiology
Brooks TA,Hawkins BT,Huber JD,Egleton RD,Davis TP
Mon Aug 01 00:00:00 EDT 2005
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
American journal of physiology. Gastrointestinal and liver physiology
Weng XH,Beyenbach KW,Quaroni A
Fri Apr 01 00:00:00 EST 2005
Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter.
Pediatric research
Ballabh P,Hu F,Kumarasiri M,Braun A,Nedergaard M
34-1600 was used in immunohistochemistry (frozen) to find that claudin-5, occludin, and JAM-1 were expressed as early as 16 wk in GM, cortex, and white matter.
Sat Oct 01 00:00:00 EDT 2005
The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development.
Journal of cell science
Rahner C,Fukuhara M,Peng S,Kojima S,Rizzolo LJ
Thu Jul 01 00:00:00 EDT 2004
Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation.
American journal of physiology. Gastrointestinal and liver physiology
Barmeyer C,Harren M,Schmitz H,Heinzel-Pleines U,Mankertz J,Seidler U,Horak I,Wiedenmann B,Fromm M,Schulzke JD
Sun Feb 01 00:00:00 EST 2004
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Pummi KP,Heape AM,Grénman RA,Peltonen JT,Peltonen SA
34-1600 was used in immunohistochemistry to report the expression of tight junction proteins in the perineurium of adult human peripheral nerve
Sun Aug 01 00:00:00 EDT 2004
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice.
The Journal of cell biology
Nitta T,Hata M,Gotoh S,Seo Y,Sasaki H,Hashimoto N,Furuse M,Tsukita S
Mon May 12 00:00:00 EDT 2003
Heterogeneity of claudin expression by alveolar epithelial cells.
American journal of respiratory cell and molecular biology
Wang F,Daugherty B,Keise LL,Wei Z,Foley JP,Savani RC,Koval M
34-1600 was used in Western Blotting to evaluate the heterogeneity of claudin expression in alveolar epithelial cells.
Tue Jul 01 00:00:00 EDT 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 EST 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 EST 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 EST 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 EST 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 EST 2003
Role of claudin interactions in airway tight junctional permeability.
American journal of physiology. Lung cellular and molecular physiology
Coyne CB,Gambling TM,Boucher RC,Carson JL,Johnson LG
Sat Nov 01 00:00:00 EST 2003
Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins.
American journal of physiology. Cell physiology
Yoo J,Nichols A,Mammen J,Calvo I,Song JC,Worrell RT,Matlin K,Matthews JB
Fri Aug 01 00:00:00 EDT 2003
Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins.
American journal of physiology. Cell physiology
Yoo J,Nichols A,Mammen J,Calvo I,Song JC,Worrell RT,Matlin K,Matthews JB
Fri Aug 01 00:00:00 EDT 2003
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Molecular biology of the cell
Wadham C,Gamble JR,Vadas MA,Khew-Goodall Y
Sun Jun 01 00:00:00 EDT 2003
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Molecular biology of the cell
Wadham C,Gamble JR,Vadas MA,Khew-Goodall Y
Sun Jun 01 00:00:00 EDT 2003
Mechanisms of diarrhea in collagenous colitis.
Gastroenterology
Bürgel N,Bojarski C,Mankertz J,Zeitz M,Fromm M,Schulzke JD
Thu Aug 01 00:00:00 EDT 2002
The renal segmental distribution of claudins changes with development.
Kidney international
Reyes JL,Lamas M,Martin D,del Carmen Namorado M,Islas S,Luna J,Tauc M,González-Mariscal L
34-1600 was used in immunohistochemistry (frozen) to examine the differential expression of occludin and several claudins in isolated renal tubules from newborn and adult rabbits.
Thu Aug 01 00:00:00 EDT 2002
