Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Clostridium botulinum Toxin B VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA0940)
Product Details
MA5-54293
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA0940
Immunogen
Recombinant Clostridium botulinum BoNT/B.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_3666543
Product Specific Information
Compatible with Direct ELISA
Target Information
Clostridium botulinum Toxin B (BoNT/B) is one of the protein neurotoxins produced by the bacteria Clostridium botulinum, which is a Gram-positive, anaerobic organism. BoNT/B, along with other botulinum toxins, is a primary virulence factor responsible for causing botulism, a serious and potentially fatal condition characterized by flaccid paralysis. BoNT/B specifically targets peripheral nerve terminals, inhibiting the release of neurotransmitters by cleaving synaptic vesicle-associated proteins, thus preventing synaptic vesicle fusion with the nerve terminal membrane. This blockade at neuromuscular junctions leads to prolonged muscle paralysis. Structurally, BoNT/B, like other botulinum toxins, consists of a heavy chain and a light chain connected by a disulfide bond. The heavy chain facilitates binding to neuronal cells and translocation into the cytosol, while the light chain acts as a protease to cleave specific proteins involved in neurotransmitter release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support