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Coronin 1A Antibody (PA1-46202) in ICC/IF
Immunocytochemistry analysis of Coronin 1A in cortical neuron-glial cell culture from E20 rat. Samples were incubated in Coronin 1A polyclonal antibody (Product # PA1-46202) using a dilution of 1:1000. This antibody (Red), and costained with mouse mAb to GFAP, dilution 1:1,000 (Green). Hoechst staining of nuclear DNA (Blue). The Coronin-1a Antibody labels protein expressed in the cytoplasm of microglia cell... View More
Product Details
PA1-46202
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C-terminal peptide of human coronin 1a coupled to KLH. [UniProt# P31146]
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
whole serum
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2082065
Product Specific Information
Suggested positive control: HL-60 cell extracts, antigen standard for CORO1A (transient overexpression lysate).
Target Information
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin-binding; Clabp coronin; Clipin-A; coronin 1; coronin, actin binding protein, 1A; coronin-1; Coronin-1A; coronin-like actin binding protein; Coronin-like protein A; Coronin-like protein p57; FLJ41407; MGC117380; TACO; Tryptophan aspartate-containing coat protein
Gene Aliases: CLABP; CLIPINA; CORO1; CORO1A; HCORO1; IMD8; Lmb3; p57; TACO
UniProt ID: (Bovine) Q92176, (Human) P31146, (Mouse) O89053, (Rat) Q91ZN1
Entrez Gene ID: (Bovine) 282196, (Human) 11151, (Pig) 100621483, (Mouse) 12721, (Rat) 155151
actin monomer binding
protein C-terminus binding
myosin heavy chain binding
protein homodimerization activity
phosphatidylinositol 3-kinase binding
actin binding
protein binding
cytoskeletal protein binding
poly(A) RNA binding
actin filament binding
identical protein binding
molecular_function
non-motor actin binding protein
phagolysosome assembly
calcium ion transport
regulation of cell shape
positive regulation of cell migration
leukocyte chemotaxis
negative regulation of vesicle fusion
cell-substrate adhesion
uropod organization
nerve growth factor signaling pathway
positive regulation of T cell proliferation
T cell homeostasis
natural killer cell degranulation
negative regulation of neuron apoptotic process
homeostasis of number of cells within a tissue
positive chemotaxis
negative regulation of actin nucleation
regulation of release of sequestered calcium ion into cytosol
early endosome to recycling endosome transport
cellular response to interleukin-4
immunological synapse formation
phagocytosis
movement of cell or subcellular component
actin filament organization
actin cytoskeleton organization
regulation of actin cytoskeleton organization
innate immune response
regulation of actin polymerization or depolymerization
cell migration
regulation of actin filament polymerization
response to cytokine
positive regulation of T cell activation
biological_process
T cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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