Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
MA1-25552 detects Cytohesin 3 from human and rat samples.
MA1-25552 has been successfully used in immunocytochemistry, and Western blot procedures.
The MA1-25552 immunogen is recombinant, full length human GRP1 protein.
GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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