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Invitrogen

Cytokeratin 5/6 Monoclonal Antibody (D5/I6 B4)

Name: Cytokeratin 5/6 Monoclonal Antibody (D5/I6 B4)
Brand: Invitrogen
SKU: MA512429
Price: 920.0 USD

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2 Published Figures

6 References

View all (18) Cytokeratin 5/6 antibodies

Datasheet

Protocols

Questions & Answers

Catalog # MA5-12429

Price (USD)

920.00

500 µL

Estimated availability date: 12-May-2025

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Datasheet

Protocols

Questions & Answers

Application

Cytokeratin 5/6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

Cytokeratin 5/6 Antibody (MA5-12429) in IHC (P)

Formalin-fixed, paraffin-embedded human mesothelioma stained with Keratin 5/6 using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

Cytokeratin 5/6 Antibody in Western Blot (WB)

Cytokeratin 5/6 Antibody in Immunohistochemistry (IHC)

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Product Details

MA5-12429

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

D5/I6 B4

Immunogen

Isolated cytokeratin 5

Conjugate

Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10982609

Product Specific Information

MA5-12429 targets Cytokeratin 5/6 in IHC (P) applications and shows reactivity with Human samples.

The MA5-12429 immunogen is isolated cytokeratin 5.

Target Information

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Cryobiopsy: A Breakthrough Strategy for Clinical Utilization of Lung Cancer Organoids.

Cells

Park D,Lee D,Kim Y,Park Y,Lee YJ,Lee JE,Yeo MK,Kang MW,Chong Y,Han SJ,Choi J,Park JE,Koh Y,Lee J,Park Y,Kim R,Lee JS,Choi J,Lee SH,Ku B,Kang DH,Chung C

MA5-12429 was used in Immunohistochemistry to develop lung cancer organoids (LCOs) from cryobiopsy specimens, achieving a 40.7% success rate, addressing challenges in obtaining sufficient tissue for LCOs. Cryobiopsy allowed for larger tissue retrieval, especially for peripheral lesions, while LCOs retained primary tumor characteristics and high cancer cell purity.

Fri Jul 14 00:00:00 UTC 2023

The prognostic and predictive significance of cytokeratin 5/6 and epidermal growth factor receptor in metastatic triple-negative breast cancer treated with maintenance capecitabine.

Translational cancer research

Zhu Y,Li K,Zhang J,Wang L,Sheng L,Yan L

MA5-12429 was used in Immunohistochemistry to investigate the correlation between CK5/6 and EGFR expression and triple-negative breast cancer prognosis, and the efficacy of capecitabine maintenance.

Mon Mar 01 00:00:00 UTC 2021

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.

Nature communications

Kim M,Mun H,Sung CO,Cho EJ,Jeon HJ,Chun SM,Jung DJ,Shin TH,Jeong GS,Kim DK,Choi EK,Jeong SY,Taylor AM,Jain S,Meyerson M,Jang SJ

Published figure using Cytokeratin 5/6 monoclonal antibody (Product # MA5-12429) in Immunohistochemistry

Thu Sep 05 00:00:00 UTC 2019

Role of β-Interferon Inducer (DEAE-Dextran) in Tumorigenesis by VEGF and NOTCH1 Inhibition along with Apoptosis Induction.

Frontiers in pharmacology

Bakrania AK,Variya BC,Patel SS

Published figure using Cytokeratin 5/6 monoclonal antibody (Product # MA5-12429) in Immunohistochemistry

Wed Sep 30 00:00:00 UTC 2020

The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast: CD44/CD24 expression in breast cancer.

Pathology, research and practice

Kapucuoğlu N,Bozkurt KK,Başpınar Ş,Koçer M,Eroğlu HE,Akdeniz R,Akçil M

MA5-12429 was used in immunohistochemistry to evaluate the expression of CD24, CD44, CD133 and ALDH1 in invasive ductal carcinoma of the breast

Thu Oct 01 00:00:00 UTC 2015

Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.

European journal of cancer (Oxford, England : 1990)

Perrone F,Jocollè G,Pennati M,Deraco M,Baratti D,Brich S,Orsenigo M,Tarantino E,De Marco C,Bertan C,Cabras A,Bertulli R,Pierotti MA,Zaffaroni N,Pilotti S

MA5-12429 was used in immunohistochemistry to determine the activation profile of EGFR, PDGFRB, and PDGFRA receptors and their downstream effectors in diffuse malignant peritoneal mesothelioma specimens

Fri Oct 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: 58 kDa cytokeratin; 60-kDa keratin; CK-5; CK-6A; CK-6B; CK-6D; cytokeratin 5; cytokeratin 6A; cytokeratin 6B; cytokeratin 6C; cytokeratin 6D; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; K6A; K6B; kamp-keratin derived antimicrobial peptide; KDAMP; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6A, , type II; keratin 6A, type II; keratin 6B, type II; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6b; keratin complex 2, basic, gene 6c; keratin complex 2, gene 6a; keratin K6h; keratin, epidermal type II, K6A; keratin, epidermal, type II, K6B; Keratin, type II cytoskeletal 5; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin-5; Keratin-6-alpha; keratin-6-beta; Keratin-6A; Keratin-6B; keratin-6C; keratin-like 1 (a type II keratin sequence); krt5; mK6-alpha; mK6-beta; tuftelin interacting protein 8; Type-II keratin Kb10; type-II keratin Kb12; Type-II keratin Kb5; Type-II keratin Kb6

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Gene Aliases: 2310016L08Rik; 3300001P10Rik; AW146334; BB144589; CK-6B; CK-6C; CK-6E; CK5; CK6A; CK6B; CK6C; CK6D; DDD; DDD1; EBS2; K5; K6A; K6B; K6C; K6D; Ker2; Krt2-5; Krt2-6; Krt2-6a; Krt2-6b; Krt2-6c; KRT5; KRT5A; Krt6; KRT6A; KRT6B; KRT6C; KRT6D; KRTL1; mK6[a]; mK6[b]; MK6a; PC2; PC3; PC4; Tfip8

UniProt ID: (Human) P13647, (Human) P02538, (Human) P04259, (Mouse) Q922U2, (Mouse) P50446

Entrez Gene ID: (Human) 3852, (Human) 3853, (Human) 3854, (Mouse) 110308, (Mouse) 16687, (Mouse) 16688

Function(s)

structural constituent of cytoskeleton protein binding scaffold protein binding structural molecule activity

Process(es)

morphogenesis of an epithelium keratinization intermediate filament organization cytoskeleton organization ectoderm development Wnt signaling pathway wound healing epidermis development hemidesmosome assembly intermediate filament cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Cytokeratin 5/6 Monoclonal Antibody (D5/I6 B4)

Cytokeratin 5/6 Antibody (MA5-12429) in IHC (P)

Product Details

MA5-12429

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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Cytokeratin 5/6 Monoclonal Antibody (D5/I6 B4)

Cytokeratin 5/6 Antibody (MA5-12429) in IHC (P)

Product Details

MA5-12429

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;}

Product Specific Information

Target Information

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