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Invitrogen
Cytokeratin Pan Monoclonal Antibody (B311.1)
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Application
FIGURE: 1 / 5
Cytokeratin Pan Antibody (MA1-91326) in ICC/IF
Immunofluorescence analysis of Cytokeratin Pan was performed using 70% confluent log phase A-431 cells. The cells were fixed and permeabilized with ice-cold acetone at 4°C for 5 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Cytokeratin Pan Monoclonal Antibody (B311.1) (Product # MA1-91326, 1:125) in 0.1% BSA, incubated at 4 degree celsius overnight and then lab... View More
Product Details
MA1-91326
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
B311.1
Immunogen
Keratin fraction isolated from cultured cell line A-431, epidermoid carcinoma of vulva.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1958797
Product Specific Information
High temperature antigenic unmasking technique or enzymatic predigestion is recommended with this antibody when using paraffin-embedded tissue sections. Positive control of skin or colonic carcinoma suggested.
This antibody detects Cytokeratin 10, Cytokeratin 13, Cytokeratin 18, Cytokeratin 4, Cytokeratin 5, Cytokeratin 6 and Cytokeratin 8.
Target Information
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39.1; 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK 2e; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin 7; cytokeratin 8; Cytokeratin endo A; Cytokeratin endo B; cytokeratin type II, component Ia; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin VIB; cytokeratin VII; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; Cytokeratin-7; Cytokeratin-8; Cytokeratin-A; Cytoskeletal 57 kDa keratin; embryonic type II keratin 1; Embryonic type II keratin-1; Endo B; epidermal keratin 10; epidermal keratin VII; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolysis bullosa simplex, Dowling-Meara, Koebner; epidermolytic hyperkeratosis 1; epidermolytic hyperkeratosis; keratosis palmaris et plantaris; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; Hair alpha protein; HMWCK; intermediate filament protein; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K4; K5; K6A; K7; K76; K77; K8; kamp-keratin derived antimicrobial peptide; KDAMP; KERA; keratin 1, type II; keratin 10 (epidermolytic hyperkeratosis); keratin 10, type I; keratin 13, type I; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin 15, type I; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2 epidermis; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin 86; keratin complex 1, acidic, gene 10; keratin complex 1, acidic, gene 13; keratin complex 1, acidic, gene 14; keratin complex 1, acidic, gene 15; keratin complex 1, acidic, gene 16; keratin complex 1, acidic, gene 17; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 39; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; Keratin D; keratin intermediate filament 16a; keratin intermediate filament 16b; keratin IV; keratin K6h; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 59 kDa; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6-alpha; Keratin-6A; keratin-6C; Keratin-7; Keratin-76; Keratin-77; Keratin-8; krt1 {ECO:0000250|UniProtKB:P04264}; krt10 {ECO:0000250|UniProtKB:P13645}; krt13 {ECO:0000250|UniProtKB:P13646}; krt15 {ECO:0000250|UniProtKB:P19012}; krt17 {ECO:0000250|UniProtKB:Q04695}; krt18 {ECO:0000250|UniProtKB:P05783}; KRT1B; krt2; krt2 {ECO:0000250|UniProtKB:P35908}; krt4 {ECO:0000250|UniProtKB:P19013}; krt5; krt7; krt7 {ECO:0000250|UniProtKB:P08729}; krt76; mK6-alpha; pan Cytokeratin; pan keratin; pankeratin; Sarcolectin; suprabasal cytokeratin 10; tuftelin interacting protein 8; type I cytoskeletal 15; type I keratin KA10; Type I keratin Ka13; Type I keratin Ka14; Type I keratin Ka15; type I keratin KA16; Type I keratin Ka17; Type I keratin Ka19; type II cytokeratin A (no.8); type II cytoskeletal 1b; type II keratin Kb1; type II keratin Kb2; type II keratin Kb39; type II keratin Kb4; type II keratin Kb7; type II keratin Kb9; type II mesothelial keratin K7; type-II intermediate filament protein; Type-II keratin Kb1; type-II keratin Kb12; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; unnamed protein product
Gene Aliases: 2310001L23Rik; 2310016L08Rik; 3300001P10Rik; 39.1; 4732484G22Rik; AA960620; AI324768; AI528832; AI626930; AI663979; AL022697; AU019895; AW108092; AW146334; BB005427; BCIE; BIE; CARD2; CK-17; CK-18; CK-2e; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK18; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; CYKER; D130054E02Rik; D15Wsu77e; DDD; DDD1; EBS2; EBS3; EBS4; EHK; EHK1; EndoA; EndoC; EPPK; FNEPPK; HUMCYT2A; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1C1; K1CO; K1CP; K1CS; K1emb; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K7; K8; Ka10; Ka13; Ka14; Ka15; Ka16; Ka17; Ka19; Kb1; Kb2; Kb39; Kb4; Kb7; Kb9; Ker2; Kerd; KERIA; KERIB; KO; KPP; Krt-1.10; Krt-1.13; Krt-1.14; Krt-1.19; Krt-2.1; Krt-2.4; Krt-2.8; KRT1; Krt1-10; Krt1-13; Krt1-14; Krt1-15; Krt1-16; Krt1-17; Krt1-18; Krt1-19; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; Krt2-1; Krt2-17; Krt2-2; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; Krt239; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; Krt6; KRT6A; KRT6C; KRT6D; KRT7; KRT76; KRT77; KRT8; Krt86; KRTA; KRTB; KRTE; mK1b; mK6[a]; MK6a; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; Sak57; SCL; Tfip8; WSN1; WSN2
UniProt ID: (Human) P86104, (Bovine) P06394, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Bovine) A1L595, (Human) P05783, (Bovine) P08728, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Bovine) Q5XQN5, (Human) P13647, (Human) P02538, (Human) P08729, (Bovine) Q29S21, (Human) Q01546, (Human) Q7Z794, (Bovine) P05786, (Human) P05787, (Rat) Q6IMF3, (Mouse) P04104, (Mouse) P02535, (Mouse) Q6PAI1, (Rat) Q6IFV4, (Rat) Q6IFV1, (Mouse) Q61781, (Mouse) Q61414, (Rat) Q6IFV3, (Mouse) Q9Z2K1, (Mouse) Q9QWL7, (Rat) Q6IFU8, (Mouse) P05784, (Rat) Q5BJY9, (Mouse) P19001, (Rat) Q63279, (Mouse) Q3TTY5, (Rat) Q6IG02, (Mouse) P07744, (Rat) Q6IG00, (Rat) Q6P6Q2, (Mouse) Q922U2, (Mouse) P50446, (Mouse) Q9DCV7, (Rat) Q6IG12, (Mouse) Q3UV17, (Rat) Q6IG01, (Mouse) Q6IFZ6, (Rat) Q10758, (Mouse) P11679
Entrez Gene ID: (Human) 3848, (Bovine) 281888, (Human) 3858, (Human) 3860, (Human) 3861, (Bovine) 404111, (Bovine) 507464, (Human) 3866, (Human) 3868, (Human) 3872, (Bovine) 281889, (Human) 3875, (Bovine) 506480, (Bovine) 514812, (Human) 3880, (Human) 3849, (Human) 3850, (Bovine) 407188, (Bovine) 527819, (Human) 3851, (Bovine) 281268, (Human) 3852, (Bovine) 614456, (Human) 3853, (Human) 3855, (Bovine) 535697, (Human) 51350, (Bovine) 407189, (Human) 374454, (Bovine) 281269, (Human) 3856, (Rat) 300250, (Mouse) 16678, (Rat) 450225, (Mouse) 16661, (Mouse) 16663, (Rat) 287699, (Rat) 287701, (Mouse) 16664, (Mouse) 16665, (Rat) 287700, (Rat) 303530, (Mouse) 16666, (Mouse) 16667, (Rat) 287702, (Mouse) 16668, (Rat) 294853, (Mouse) 16669, (Rat) 360626, (Mouse) 16681, (Rat) 406228, (Mouse) 16682, (Rat) 315323, (Rat) 369017, (Mouse) 110308, (Mouse) 16687, (Mouse) 110310, (Rat) 300242, (Rat) 407757, (Mouse) 77055, (Rat) 406226, (Mouse) 406220, (Rat) 25626, (Mouse) 16691
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