Invitrogen

D4 Dopamine Receptor Polyclonal Antibody

View all (17) D4 Dopamine Receptor antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-89196

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRD4 (NP_0007882)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.27 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805410

Product Specific Information

Immunogen sequence: AWLLSPRLCD ALMAMDVMLC TASIFNLCAI SVDRFVAVAV PLRYNRQGGS RRQLLLIGAT WLLSAAVAAP VLCGLNDVRG RDPAVCRLED RDYVVYSSVC S; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Multi-pass membrane protein

Target Information

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4

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Gene Aliases: AW125663; D4R; D4RA; Drd-4; Drd4

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UniProt ID: (Mouse) P51436

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Entrez Gene ID: (Rat) 25432, (Mouse) 13491

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Function(s)
dopamine neurotransmitter receptor activity, coupled via Gi/Go dopamine neurotransmitter receptor activity protein binding drug binding SH3 domain binding dopamine binding identical protein binding signal transducer activity G-protein coupled receptor activity G-protein coupled amine receptor activity G-protein coupled receptor
Process(es)
activation of MAPK activity behavioral fear response synaptic transmission, dopaminergic response to amphetamine negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway dopamine receptor signaling pathway short-term memory circadian rhythm locomotory behavior associative learning adult locomotory behavior olfactory learning photoperiodism negative regulation of cAMP biosynthetic process positive regulation of sodium:proton antiporter activity positive regulation of kinase activity response to histamine regulation of dopamine metabolic process fear response regulation of circadian rhythm regulation of neurotransmitter secretion behavioral response to cocaine response to steroid hormone arachidonic acid secretion negative regulation of protein secretion modulation of synaptic transmission regulation of calcium-mediated signaling retina development in camera-type eye inhibitory postsynaptic potential positive regulation of penile erection negative regulation of voltage-gated calcium channel activity positive regulation of excitatory postsynaptic potential signal transduction G-protein coupled receptor signaling pathway chemical synaptic transmission sensory perception of chemical stimulus rhythmic process
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