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DCLK1 Antibody (MA5-26800) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human embryonic cerebellum tissue. To expose target proteins, heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min. Following antigen retrieval, tissues were probed with a DCLK1 monoclonal antibody (Product # MA5-26800) at a dilution of 1:500.
Product Details
MA5-26800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1F8
Immunogen
Human recombinant protein fragment corresponding to amino acids 193-492 of DCLK1 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2724193
Target Information
DCAMKL1 (DCLK1) serine/threonine kinase or DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcium/calmodulin-dependent protein kinase type I-like CPG16; CLICK-I beta; double cortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin and calcium/calmodulin-dependent protein kinase-like 1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; RP11-113P14.1; Serine/threonine-protein kinase DCLK1
Gene Aliases: 1700113D08Rik; 2810480F11Rik; AI836758; Ania4; CL1; Click-I; CLICK1; Cpg16; DCAMKL1; DCDC3A; Dcl; DCLK; DCLK1; KIAA0369; mKIAA0369
UniProt ID: (Human) O15075, (Mouse) Q9JLM8, (Rat) O08875
Entrez Gene ID: (Human) 9201, (Mouse) 13175, (Rat) 83825
neuron migration
protein phosphorylation
nervous system development
central nervous system development
response to virus
endosomal transport
central nervous system projection neuron axonogenesis
forebrain development
intracellular signal transduction
axon extension
dendrite morphogenesis
multicellular organism development
axonogenesis
brain development
phosphorylation
cell differentiation
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