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Product Details
H00079139-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1B9
Immunogen
DERL1 (AAH02457, 134 a.a. approximately 233 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).^M
^M
Immunogen sequence: AQLNRDMIVS FWFGTRFKAC YLPWVILGFN YIIGGSVINE LIGNLVGHLY FFLMFRYPMD LGGRNFLSTP QFLYRWLPSR RGGVSGFGVP PASMRRAADQ
Target Information
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Degradation in endoplasmic reticulum protein 1; Der1-like domain family, member 1; Der1-like protein 1; Derlin-1; DERtrin-1
Gene Aliases: DER-1; DER1; DERL1; UNQ243/PRO276
UniProt ID: (Human) Q9BUN8
Entrez Gene ID: (Human) 79139
response to unfolded protein
intracellular transport of viral protein in host cell
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
positive regulation of protein ubiquitination
protein destabilization
positive regulation of protein binding
ERAD pathway
establishment of protein localization
protein homooligomerization
ER-associated misfolded protein catabolic process
Performance Guarantee
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