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Product Details
H00084649-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4C1
Immunogen
DGAT2 (NP_115953.2, 289 a.a. approximately 388 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: IFEEGSWGRW VQKKFQKYIG FAPCIFHGRG LFSSDTWGLV PYSKPITTVV GEPITIPKLE HPTQQDIDLY HTMYMEALVK LFDKHKTKFG LPETEVLEVN
Target Information
Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Diacylglycerol O-acyltransferase 2; diacylglycerol O-acyltransferase homolog 2; diacylglycerol O-acyltransferase-like protein 2; Diglyceride acyltransferase 2; DKFZp686A15125
Gene Aliases: ARAT; DGAT2; GS1999FULL; HMFN1045; UNQ738/PRO1433
UniProt ID: (Human) Q96PD7
Entrez Gene ID: (Human) 84649
glycerol metabolic process
positive regulation of triglyceride biosynthetic process
triglyceride biosynthetic process
lipid storage
low-density lipoprotein particle clearance
long-chain fatty-acyl-CoA metabolic process
cellular triglyceride homeostasis
acylglycerol acyl-chain remodeling
retinol metabolic process
cholesterol homeostasis
positive regulation of gluconeogenesis
negative regulation of fatty acid oxidation
diacylglycerol metabolic process
regulation of lipoprotein metabolic process
fatty acid homeostasis
fat pad development
cellular response to oleic acid
regulation of cholesterol metabolic process
regulation of plasma lipoprotein particle levels
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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