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Product Details
H00001745-M15
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4B7
Immunogen
DLX1 (NP_835221, 181 a.a. approximately 254 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: SKFKKLMKQG GAALEGSALA NGRALSAGSP PVPPGWNPNS SSGKGSGGNA GSYIPSYTSW YPSAHQEAMQ QPQL*
Target Information
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-beta superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DII B; distal-less homeo box 1; Homeobox protein DLX-1
Gene Aliases: Dlx; Dlx-1; DLX1
UniProt ID: (Human) P56177, (Mouse) Q64317
Entrez Gene ID: (Human) 1745, (Mouse) 13390
negative regulation of transcription from RNA polymerase II promoter
proximal/distal pattern formation
subpallium development
hippocampus development
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
cerebral cortex GABAergic interneuron fate commitment
odontogenesis of dentin-containing tooth
negative regulation of neuron apoptotic process
negative regulation of Notch signaling pathway
embryonic skeletal system development
negative regulation of oligodendrocyte differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
forebrain neuron differentiation
cerebral cortex GABAergic interneuron differentiation
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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