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Immunogen sequence: CEYKYDGQRA QIHALEGGEV KIFSRNQEDN TGKYPDIISR IPKIKLPSVT SFILDTEAVA WDREKKQIQP FQVLTTRKRK EVDASEIQVQ VCLYAFDLIY LNGESLVREP LSRRRQLLRE NFVETEGEFV FATSLDTKDI EQIAEFLEQS VKDSCEGLMV KTLDVDATYE IAKRSHNWLK LKKDYLDGVG DTLDLVVIGA YLGRGKRAGR YGGFLLASYD EDSEEL; Positive Samples: MCF7, A-549, K-562, Jurkat, 22Rv1, Mouse testis; Cellular Location: Nucleus
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. There are three alternatively spliced transcript variants encoding the same protein described for this gene.
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Protein Aliases: DNA ligase 1; DNA ligase I; ligase 1; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1
Gene Aliases: AL033288; Lig-1; LIG1; LigI
UniProt ID: (Human) P18858, (Mouse) P37913
Entrez Gene ID: (Human) 3978, (Mouse) 16881
Molecular Function:
DNA ligase
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