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Product Details
PA5-52333
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DNA Ligase III
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2640647
Product Specific Information
Immunogen sequence: CDPRHKDCLL REFRKLCAMV ADNPSYNTKT QIIQDFLRKG SAGDGFHGDV YLTVKLLLPG VIKTVYNLND KQIVKLFSRI FNCNPDDMAR DLEQGDVSET IRVFFEQSKS FPPAAKSLLT IQEVDEFLLR LSKLTKE
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
There are four distinct ligase proteins found in mammalian cells. The activity of these DNA ligases is required for the joining of DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III gene product migrates as a 100 kDa (a-form) protein in somatic tissues, is ubiquitously expressed and complexes with XRCC-1 and a 97 kDa (beta form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in the base excision repair pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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