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            • Primary Antibodies ›
            • Topoisomerase I Antibodies

            Exalpha

            DNA Topoisomerase 1 Polyclonal Antibody

            View all (28) Topoisomerase I antibodies
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            Catalog # X2732P
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            Price (USD)
            359.00
            100 µg
             
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            Cite DNA Topoisomerase 1 Polyclonal Antibody

            Product Details

            X2732P

            Applications
            Tested Dilution
            Publications

            Immunohistochemistry (Paraffin) (IHC (P))

            5-10 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Rabbit / Ig

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Synthetic peptide made to human DNA Topoisomerase 1

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.5-2 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS

            Contains

            0.08% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            Positive control: Found in Endothelial cells.

            Target Information

            This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: DNA topoisomerase 1; DNA topoisomerase I; RP3-511B24.2; Topoisomerase 1; type I DNA topoisomerase

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            Gene Aliases: TOP1; TOPI

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            UniProt ID: (Human) P11387

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            Entrez Gene ID: (Human) 7150

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            Function(s)

            core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity DNA topoisomerase type II (ATP-hydrolyzing) activity protein binding poly(A) RNA binding DNA topoisomerase

            Process(es)

            DNA replication DNA topological change chromatin remodeling chromosome segregation circadian rhythm programmed cell death viral process phosphorylation protein sumoylation circadian regulation of gene expression embryonic cleavage response to drug
            It has to be done as per old AB suggested Products section.
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