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In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human DNER is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Brain EGF repeat-containing transmembrane protein; Delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet
Gene Aliases: A930026D19Rik; BET; Bret; Dner
UniProt ID: (Mouse) Q8JZM4
Entrez Gene ID: (Mouse) 227325
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