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Invitrogen

DNM1L Polyclonal Antibody

View all (58) DNM1L antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)

Application

DNM1L Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

DNM1L Antibody (PA5-87472) in ICC/IF

Immunofluorescence analysis of DNM1L in NIH/3T3 cells. Samples were incubated with DNM1L Polyclonal antibody (Product # PA5-87472) using a dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.

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Product Details

PA5-87472

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

Immunocytochemistry (ICC/IF)

1:50-1:200

ELISA (ELISA)

1 µg/mL

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 610-736 of human DRP1 (NP_0361922)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

2.64 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2804178

Product Specific Information

Positive Samples: PC-12; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Endomembrane system, Golgi apparatus, Membrane, Mitochondrion outer membrane, Peripheral membrane protein, Peroxisome, clathrin-coated pit, cytosol, secretory vesicle, synaptic vesicle membrane

Immunogen sequence: IPIMPASPQK GHAVNLLDVP VPVARKLSAR EQRDCEVIER LIKSYFLIVR KNIQDSVPKA VMHFLVNHVK DTLQSELVGQ LYKSSLLDDL LTESEDMAQR RKEAADMLKA LQGASQIIAE IRETHLW

Target Information

A human dynamin-related protein, DRP1 contributes to mitochondrial division in mammalian cells. It plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-terminal region; Dnm1p/Vps1p-like protein; DVLP; Dymple; dynamin 1-like; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-1-like protein; Dynamin-like protein; dynamin-like protein 1; Dynamin-like protein 4; Dynamin-like protein IV; Dynamin-related protein 1; DYNIV 11; DYNIV-11; EC 3.6.5.5; FLJ41912; HdynIV; N-terminal region; VPS1

Gene Aliases: 6330417M19Rik; AI450666; DLP1; DNM1L; Dnml1; Dnmlp1; DRP1; DVLP; DYMPLE; EMPF; HDYNIV; python

UniProt ID: (Human) O00429, (Rat) O35303, (Mouse) Q8K1M6

Entrez Gene ID: (Human) 10059, (Rat) 114114, (Mouse) 74006

Function(s)

GTPase activity GTPase activator activity protein binding GTP binding lipid binding Rab GTPase binding GTP-dependent protein binding ubiquitin protein ligase binding protein homodimerization activity identical protein binding nucleotide binding hydrolase activity membrane traffic protein

Process(es)

mitochondrial fission release of cytochrome c from mitochondria dynamin polymerization involved in mitochondrial fission endocytosis cellular component disassembly involved in execution phase of apoptosis regulation of mitochondrion organization peroxisome fission regulation of protein oligomerization positive regulation of apoptotic process positive regulation of GTPase activity mitochondrial fragmentation involved in apoptotic process positive regulation of protein secretion protein oligomerization protein homotetramerization heart contraction membrane fusion necroptotic process mitochondrion morphogenesis protein localization to mitochondrion positive regulation of mitochondrial fission mitochondrial membrane fission positive regulation of release of cytochrome c from mitochondria regulation of peroxisome organization regulation of mitophagy regulation of ATP metabolic process positive regulation of intrinsic apoptotic signaling pathway metabolic process programmed cell death

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