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Invitrogen
DOPA Decarboxylase Polyclonal Antibody
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Application
FIGURE: 1 / 5
DOPA Decarboxylase Antibody (PA1-4652) in ICC/IF
Immunofluorescence analysis of DOPA Decarboxylase was performed using 70% confluent log phase SH-SY5Y and SK-O-V3 cells. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with DOPA Decarboxylase Polyclonal Antibody (Product # PA1-4652) at 1:100 dilution in 0.1%... View More
Product Details
PA1-4652
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Guinea pig,
Human,
Sheep,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the N-terminal region of human DDC conjugated to KLH
Conjugate
Unconjugated
Form
Liquid
Concentration
0.15 mg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2088961
Product Specific Information
This antibody is specific for the ~55 kDa DDC protein in Western blots of rat adrenal medulla.
Target Information
DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AADC; aromatic L-amino acid decarboxylase; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); HGNC:2719; L-Dopa decarboxylase
Gene Aliases: AADC; DDC
UniProt ID: (Bovine) P27718, (Human) P20711, (Guinea pig) P22781, (Rat) P14173
Entrez Gene ID: (Sheep) 101106765, (Bovine) 280762, (Dog) 606852, (Rabbit) 100355492, (Human) 1644, (Guinea pig) 100135516, (Rat) 24311
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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