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Proteintech
DRG1 Polyclonal Antibody
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Product Details
13190-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DRG1 Fusion Protein Ag3866 (1-367 aa encoded by BC020803)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSSTLAKIA EIEAEMARTQ KNKATAHHLG LLKARLAKLR RELITPKGGG GGGPGEGFDV AKTGDARIGF VGFPSVGKST LLSNLAGVYS EAAAYEFTTL TTVPGVIRYK GAKIQLLDLP GIIEGAKDGK GRGRQVIAVA RTCNLILIVL DVLKPLGHKK IIENELEGFG IRLNSKPPNI GFKKKDKGGI NLTATCPQSE LDAETVKSIL AEYKIHNADV TLRSDATADD LIDVVEGNRV YIPCIYVLNK IDQISIEELD IIYKVPHCVP ISAHHRWNFD DLLEKIWDYL KLVRIYTKPK GQLPDYTSPV VLPYSRTTVE DFCMKIHKNL IKEFKYALVW GLSVKHNPQK VGKDHTLEDE DVIQIVKK (1-367 aa encoded by BC020803)
Target Information
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: developmentally regulated GTP-binding protein 1; Developmentally-regulated GTP-binding protein 1; DRG-1; NEDD-3; Neural precursor cell expressed developmentally down-regulated protein 3; neural precursor cell expressed, developmentally down-regulated 3; TRAFAC GTPase DRG1; Translation factor GTPase DRG1
Gene Aliases: DRG1; NEDD3
UniProt ID: (Human) Q9Y295
Entrez Gene ID: (Human) 4733, (Rat) 305470
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