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            • Primary Antibodies ›
            • DUSP8 Antibodies

            Invitrogen

            DUSP8 Polyclonal Antibody

            View all (4) DUSP8 antibodies
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            Cite DUSP8 Polyclonal Antibody

            • Antibody Testing Data (5)
            Application
            DUSP8 Antibody in Immunocytochemistry (ICC/IF)
            Group 53 Created with Sketch.

            FIGURE: 1 / 5

            DUSP8 Antibody (PA5-109668) in ICC/IF

            Immunofluorescence analysis of DUSP8 in NIH/3T3 cells. Samples were incubated with DUSP8 Polyclonal antibody (Product # PA5-109668) using a dilution of 1:1,000 (40x lens). Blue: DAPI for nuclear staining.
            View Product

            DUSP8 Antibody in Immunocytochemistry (ICC/IF)
            DUSP8 Antibody in Immunocytochemistry (ICC/IF)
            DUSP8 Antibody in Immunocytochemistry (ICC/IF)
            DUSP8 Antibody in Immunocytochemistry (ICC/IF)
            DUSP8 Antibody in Western Blot (WB)

            Product Details

            PA5-109668

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:1,000-1:5,000
            -

            Immunocytochemistry (ICC/IF)

            1:500-1:1,000
            -

            ELISA (ELISA)

            1 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DUSP8 (NP_0044112)
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.97 mg/mL

            Purification

            Affinity Chromatography

            Storage buffer

            PBS, pH 7.3, with 50% glycerol

            Contains

            0.05% ProClin 300

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2855079

            Product Specific Information

            Immunogen sequence: NleAGDRLPR KVNl

            Target Information

            The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: Dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH-5; FLJ42476; FLJ42958; H1 phosphatase, vaccinia virus homolog; Neuronal tyrosine threonine phosphatase 1; neuronal tyrosine/threonine phosphatase 1; OTTHUMP00000164487; serine/threonine specific protein phosphatase

            View more View less

            Gene Aliases: 5530400B01Rik; AI593498; C11orf81; DUSP8; HB5; HVH-5; HVH8; M3/6; Nttp1; VH5

            View more View less

            UniProt ID: (Human) Q13202, (Mouse) O09112

            View more View less

            Entrez Gene ID: (Human) 1850, (Rat) 361679, (Mouse) 18218

            View more View less

            Function(s)

            protein tyrosine phosphatase activity phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity molecular_function phosphoprotein phosphatase activity protein tyrosine/serine/threonine phosphatase activity hydrolase activity protein phosphatase

            Process(es)

            inactivation of MAPK activity dephosphorylation peptidyl-tyrosine dephosphorylation biological_process protein dephosphorylation
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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