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Predicted to react with Mouse and Rat samples.
DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: double homeobox 4-like; double homeobox B-like 1; Double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10
Gene Aliases: DUX10; DUX4; DUX4L; Duxbl; RGD1311053
UniProt ID: (Human) Q9UBX2
Entrez Gene ID: (Human) 100288687, (Rat) 306226
Molecular Function:
homeodomain transcription factor
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