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Invitrogen
DYNC1H1 Polyclonal Antibody
Application
FIGURE: 1 / 5
DYNC1H1 Antibody (PA5-49451) in IHC (P)
Immunohistochemistry analysis of DYNC1H1 in paraformaldehyde-fixed, paraffin-embedded human testis sections. Samples were incubated with DYNC1H1 polyclonal antibody (Product # PA5-49451) using a dilution of 1:25 for 1 hours at 37°C followed by an undiluted biotinylated goat polyvalent antibody. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0.5 hour at room temperature; antigen retrieval was... View More
Product Details
PA5-49451
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 4202-4236 amino acids from the C-terminal region of human DYNC1H1.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2634905
Target Information
DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1) is a gene that encodes a protein belonging to the dynein family, which are motor proteins critical for various cellular processes. Dyneins are responsible for retrograde intracellular transport along microtubules, meaning they move cargo from the periphery of the cell towards the nucleus. The DYNC1H1 protein is a heavy chain component of cytoplasmic dynein 1, which plays a key role in the movement of organelles, vesicles, and other cellular components. Mutations in DYNC1H1 have been associated with several neurological disorders, including spinal muscular atrophy with lower extremity predominance (SMA-LED) and Charcot-Marie-Tooth disease type 2O (CMT2O). Research into DYNC1H1 continues to uncover its involvement in cellular mechanics and its implications in various genetic conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1; legs at odd angle; sprawling
Gene Aliases: 9930018I23Rik; AI894280; CMT2O; DHC1; DHC1a; DNCH1; Dnchc1; DNCL; Dnec1; DNECL; DYHC; DYNC1H1; HL-3; KIAA0325; Loa; MAP1C; mKIAA0325; P22; SMALED1; Swl
UniProt ID: (Human) Q14204, (Mouse) Q9JHU4
Entrez Gene ID: (Human) 1778, (Mouse) 13424
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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