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Invitrogen
DYRK1A Polyclonal Antibody
Application
FIGURE: 1 / 4
DYRK1A Antibody (PA5-95499) in WB
Western blot was performed using Anti-DYRK1A Polyclonal Antibody (Product # PA5-95499) and a 90kDa band corresponding to Dual specificity tyrosine-phosphorylation-regulated kinase 1A was observed across all the tested cell lines and tissues, except HEK-293 and Mouse Brain. Nuclear enriched extracts (40 µg lysate) of HEK-293 (Lane 1), K-562 (Lane 2), HEL 92.1.7 (Lane 3), SH-SY5Y (Lane 4), PC-3 (Lane 5), HeLa (Lane 6), Jurkat (Lane 7), Mouse Ovary (Lane 8), Mouse Brain (Lane 9) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (P... View More
Product Details
PA5-95499
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human DYRK1A recombinant protein (Position: H38-M269).
Conjugate
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807301
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, rat skeletal muscle tissue. ICC/IF: U2OS cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
DYRK1A is a dual specificity kinase involved in cell proliferation. The gene for DYRK1A is located in the Down syndrome critical region of chromosome 21, and has been implicated in the pathogenesis of this disease. DYRK1A catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual Specificity Yak1-related kinase; hMNB; HP86; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; OTTHUMP00000109090; Protein kinase minibrain homolog; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Gene Aliases: DYRK; DYRK1; DYRK1A; HP86; MNB; MNBH; MRD7; PSK47
UniProt ID: (Human) Q13627, (Rat) Q63470
Entrez Gene ID: (Human) 1859, (Rat) 25255
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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