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Invitrogen
Doublecortin Monoclonal Antibody (3 e1)
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Application
FIGURE: 1 / 3
Doublecortin Antibody (MA5-33102) in ICC/IF
Immunocytochemistry analysis of Doublecortin in rat cortical neuron-glial cells showing strong cytoplasmic labeling of a small population of developing neurons and their processes with Doublecortin monoclonal antibody (Product # MA5-33102) using a dilution of 1:1,000 (red). Anti-MAP2 using a dilution of 1:10,000 (green) labels dendrites and perikarya or mature neurons, and additional nuclear staining was do... View More
Product Details
MA5-33102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3 e1
Immunogen
Full length recombinant human protein expressed in and purified from E. coli
Conjugate
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2802652
Target Information
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: doublecortex; Doublin; Lis-X; LIS-XD; Lissencephalin-X; lissencephaly, X-linked (doublecortin); Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316
Gene Aliases: DBCN; Dbct; DC; Dcn; DCX; LISX; SCLH; XLIS
UniProt ID: (Human) D3DUY9, (Mouse) O88809
Entrez Gene ID: (Bovine) 787968, (Human) 1641, (Rat) 84394, (Mouse) 13193
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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