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Proteintech

EDEM3 Polyclonal Antibody

View all (7) EDEM3 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)

Application

EDEM3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

EDEM3 Antibody (27310-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using 27310-1-AP (EDEM3 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

EDEM3 Antibody in Immunoprecipitation (IP)

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Product Details

27310-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EDEM3 Fusion Protein Ag26123 (1-80 aa encoded by BC016464)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DNAASISPS EQTSNPTENH ETTNLNGECT DLDNQLQEQS ETEEDSNPNV SWGKKVQPID SILADWNEDI EAFEMMEKDE L (1-80 aa encoded by BC016464)

Target Information

Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-1,2-mannosidase EDEM3; ER degradation enhancer, mannosidase alpha-like 3; ER degradation-enhancing -mannosidase-like protein 3; ER degradation-enhancing alpha-mannosidase-like 3; ER degradation-enhancing alpha-mannosidase-like protein 3

Gene Aliases: 2310050N11Rik; C1orf22; EDEM3

UniProt ID: (Human) Q9BZQ6, (Mouse) Q2HXL6

Entrez Gene ID: (Human) 80267, (Mouse) 66967

Function(s)

alpha-mannosidase activity glycoprotein endo-alpha-1,2-mannosidase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding lytic transglycosylase activity mannosidase activity mannosyl-oligosaccharide mannosidase activity galactosidase activity glucosidase activity trehalase activity fucosidase activity hexosaminidase activity amylase activity hydrolase activity dextrin alpha-glucosidase activity starch alpha-glucosidase activity beta-glucanase activity beta-6-sulfate-N-acetylglucosaminidase activity glucan endo-1,4-beta-glucosidase activity

Process(es)

N-glycan processing ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response endoplasmic reticulum mannose trimming mannose trimming involved in glycoprotein ERAD pathway glycoprotein catabolic process response to unfolded protein proteasome-mediated ubiquitin-dependent protein catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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