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Application
FIGURE: 1 / 3
EDEM3 Antibody (PA5-68189) in WB
Journal of diabetes research 2024 -
Figure 6 HJXJ intervention decreased ER stress and the expression of the downstream molecules in HGMCs induced by high doses of sugar (30 mmol/mL) and TGF beta 1 (5 ng/mL). (a) The mRNA levels of ER stress chaperone genes ( CHOP and GRP78 ) were detected by RT-qPCR analysis. (b) The protein levels of CHOP and GRP78 were measured by Western blotting assays. (c) RT-qPCR was performed to evaluate the expressio... View More
Product Details
PA5-68189
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human EDEM3.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2691663
Product Specific Information
Predicted to react with Mouse samples.
Target Information
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-1,2-mannosidase EDEM3; ER degradation enhancer, mannosidase alpha-like 3; ER degradation-enhancing -mannosidase-like protein 3; ER degradation-enhancing alpha-mannosidase-like 3; ER degradation-enhancing alpha-mannosidase-like protein 3
Gene Aliases: 2310050N11Rik; C1orf22; EDEM3
UniProt ID: (Human) Q9BZQ6, (Mouse) Q2HXL6
Entrez Gene ID: (Human) 80267, (Mouse) 66967
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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