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Invitrogen

EIF2A Polyclonal Antibody

3 References

View all (18) eIF2A antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Catalog # PA5-41916

Price (EUR)

518,00

100 µL

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Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (2)

Application

EIF2A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 2

EIF2A Antibody (PA5-41916) in IHC (P)

Immunohistochemistry (paraffin-embedded) analysis of human skin tissue using an anti-eIF2 alpha polyclonal antibody (Product # PA5-41916).

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Product Details

PA5-41916

Applications

Tested Dilution

Publications

Western Blot (WB)

2.5 µg/mL

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

4-8 µg/mL

Product Specifications

Species Reactivity

Human

Published species

Mouse, Yeast, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the C-terminal of human EIF2A (aa 504-553).

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2609709

Product Specific Information

Peptide sequence: DKSPDLAPTP APQSTPRNTV SQSISGDPEI DKKIKNLKKK LKAIEQLKEQ

Sequence homology: Cow: 86%; Dog: 100%; Goat: 83%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%

Target Information

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors.

GeroScience

Mariner BL,Rodriguez AS,Heath OC,McCormick MA

PA5-41916 was used in Western Blot to show that multiple tRNA synthetase inhibitors can greatly upregulate activity of the ubiquitin proteasome system (UPS) in cells in an ATF4-dependent manner.

Mon Apr 01 00:00:00 UTC 2024

Genetic landscape of T cells identifies synthetic lethality for T-ALL.

Communications biology

O'Meara CP,Guerri L,Lawir DF,Mateos F,Iconomou M,Iwanami N,Soza-Ried C,Sikora K,Siamishi I,Giorgetti O,Peter S,Schorpp M,Boehm T

PA5-41916 was used in Western Blot to delineate the genetic network underlying the development of T cells in zebrafish, establish the nature of synthetic lethal interactions, and inform combinatory inhibitor treatments in preventing progression of T-cell acute lymphoblastic leukaemia.

Wed Oct 20 00:00:00 UTC 2021

Magnesium depletion extends fission yeast lifespan via general amino acid control activation.

MicrobiologyOpen

Ohtsuka H,Kobayashi M,Shimasaki T,Sato T,Akanuma G,Kitaura Y,Otsubo Y,Yamashita A,Aiba H

PA5-41916 was used in Western Blot to investigate effects of magnesium on Schizosaccharomyces pombe lifespan.

Mon Mar 01 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: 65 kDa eukaryotic translation initiation factor 2A; eIF-2A; Eukaryotic translation initiation factor 2A; eukaryotic translation initiation factor 2A, 65kDa

Gene Aliases: CDA02; EIF-2A; EIF2A; MST089; MSTP004; MSTP089

UniProt ID: (Human) Q9BY44

Entrez Gene ID: (Human) 83939

Function(s)

tRNA binding translation initiation factor activity protein binding ribosome binding cadherin binding involved in cell-cell adhesion translation factor translation initiation factor translational protein

Process(es)

translational initiation regulation of translation protein phosphorylation positive regulation of signal transduction SREBP signaling pathway ribosome assembly cell-cell adhesion

Performance Guarantee

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