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产品信息
20499-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EIF2AK1 Fusion Protein Ag14236 (281-630 aa encoded by BC006524)
偶联物
Unconjugated
形式
Liquid
浓度
0.36 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: FAEPTPEKE KRFGESDTEN QNNKSVKYTT NLVIRESGEL ESTLELQENG LAGLSASSIV EQQLPLRRNS HLEESFTSTE ESSEENVNFL GQTEAQYHLM LHIQMQLCEL SLWDWIVERN KRGREYVDES ACPYVMANVA TKIFQELVEG VFYIHNMGIV HRDLKPRNIF LHGPDQQVKI GDFGLACTDI LQKNTDWTNR NGKRTPTHTS RVGTCLYASP EQLEGSEYDA KSDMYSLGVV LLELFQPFGT EMERAEVLTG LRTGQLPESL RKRCPVQAKY IQHLTRRNSS QRPSAIQLLQ SELFQNSGNV NLTLQMKIIE QEKEIAELKK QLNLLSQDKG VRDDGKDGGV G (281-630 aa encoded by BC006524)
靶标信息
EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; Heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; Hemin-sensitive initiation factor 2-alpha kinase; hHRI
基因别名: EIF2AK1; HCR; HRI; KIAA1369; PRO1362
UniProt ID: (Human) Q9BQI3
Entrez Gene ID: (Human) 27102
