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Application
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ERMAP Antibody (MA5-24371) in Flow
Flow cytometry of ERMAP in K562 human chronic myelogenous leukemia cell line. Samples were incubated in ERMAP monoclonal antibody (Product # MA5-24371) or isotype control antibody followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody.
Product Details
MA5-24371
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
767505
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ERMAP His30-Ala155
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2605958
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Erythroblast membrane-associated protein (ERMAP) is a gene situated on chromosome 1p34.2, encoding a protein primarily associated with erythroblast cells. ERMAP is expressed in erythroid lineage cells and plays a crucial role as an adhesion molecule, involved in the maturation and stability of the erythrocyte membrane. This protein is associated with the Scianna blood group system, and variations within the ERMAP gene lead to different antigenic expressions which are important in transfusion medicine. ERMAP is also significant in mediating cell-cell adhesion processes essential for erythropoiesis, where it facilitates receptor-ligand interactions in hematopoietic stem cells. Mutations or polymorphisms in ERMAP can result in altered blood group antigens, impacting blood transfusion compatibility and potentially leading to hemolytic reactions. Given its distinct role in erythrocyte formation, ERMAP is a subject of interest for further research into blood-related disorders and their genetic underpinnings.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: erythroblast membrane-associated protein (Scianna blood group); Erythroid membrane-associated protein; hERMAP; MGC118810; MGC118811; Radin blood group; Radin blood group (Rd); Radin blood group antigen; RDMGC118812; Scianna blood group; Scianna blood group (Sc); Scianna blood group antigen; SCMGC118813
Gene Aliases: BTN5; ERMAP; PRO2801; RD; SC
UniProt ID: (Human) Q96PL5
Entrez Gene ID: (Human) 114625
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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