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            • Primary Antibodies ›
            • ERO1L Antibodies

            Invitrogen

            ERO1L Polyclonal Antibody

            Advanced Verification
            View all (17) ERO1L antibodies
            Datasheet
            Protocols
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            Datasheet
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            Questions & Answers

            Cite ERO1L Polyclonal Antibody

            • Antibody Testing Data (5)
            • Advanced Verification (1)
            Application
            ERO1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 6

            ERO1L Antibody (PA5-83121) in IHC (P)

            Immunohistochemical analysis of ERO1L in human esophagus using ERO1L Polyclonal Antibody (Product # PA5-83121) shows strong granular cytoplasmic positivity in squamous epithelial cells.
            View Product

            ERO1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            ERO1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            ERO1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            ERO1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            ERO1L Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            ERO1L Antibody

            Product Details

            PA5-83121

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            0.04-0.4 µg/mL
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            1:1,000-1:2,500
            -
            Product Specifications

            Species Reactivity

            Human, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Recombinant protein corresponding to Human ERO1A. Recombinant protein control fragment (Product #RP-89562).
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.1 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS, pH 7.2, with 40% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2790277

            Product Specific Information

            Immunogen sequence: FNNYRLFPRL QKLLESDYFR YYKVNLKRPC PFWNDISQCG RRDCAVKPCQ SDEVPDGIKS ASYKYSEEAN NLIEECEQAE RLGAVDESLS EETQKAVLQW TKHDDSSDNF CEADDIQSPE AEYVDLLLNP ERYTGYKGPD AWKIWNVIY

            Target Information

            ERO1L (endoplasmic oxidoreductin-1-like protein) is localized in ER membrane as peripheral membrane protein on the lumenal side. Its association with ERP44 is essential for its retention in the ER and is unique in coupling oxygen reduction to de novo disulfides formation. The ERO1L enzyme is broadly distributed at low levels in several tissues with highest levels in the upper digestive tract and is stimulated by hypoxia via HIF-signaling. ERO1L generally exists as monomer, but has the ability to function as monomer or homodimer and interacts with PDILT. After translation, ERO1L gets n-glycosylated and the disulfide bonds constitute the redox-active center whereby the Cys-94/Cys-99 disulfide bond accepts an electron from P4HB followed by funneling the same to the active site disulfide Cys-394/Cys-397. ERO1L acts by oxidizing directly to P4HB/PDI isomerase through direct disulfide exchange and associates with ERP44. ERO1L is implicated in immunoglobulin folding, oxidative stress, release of unfolded cholera toxin from reduced P4HB/PDI upon Vibrio cholerae infection, and plays a key role in ER stress-induced CHOP-dependent apoptosis through inositol 1,4,5-trisphosphate receptor IP3R1 activation.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: Endoplasmic oxidoreductin-1-like protein; Endoplasmic reticulum oxidoreductase alpha; Endoplasmic reticulum oxidoreductin-1-like protein; ero1; ERO1-L; ERO1-L-alpha; ERO1-like protein alpha; Global ischemia-induced protein 11; Oxidoreductin-1-L-alpha

            View more View less

            Gene Aliases: ERO1-alpha; ERO1-L; ERO1-L-alpha; ERO1A; Ero1alpha; ERO1L; ERO1LA; Giig11; UNQ434/PRO865

            View more View less

            UniProt ID: (Human) Q96HE7, (Rat) Q8R4A1

            View more View less

            Entrez Gene ID: (Human) 30001, (Rat) 171562

            View more View less

            Function(s)

            protein disulfide isomerase activity protein binding protein disulfide oxidoreductase activity disulfide oxidoreductase activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor oxidoreductase

            Process(es)

            response to reactive oxygen species protein folding cellular protein modification process response to temperature stimulus organ senescence 4-hydroxyproline metabolic process protein maturation by protein folding extracellular matrix organization endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress cell redox homeostasis brown fat cell differentiation chaperone mediated protein folding requiring cofactor release of sequestered calcium ion into cytosol oxidation-reduction process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to hypoxia
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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