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Application
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ESCO1 Antibody (PA5-37183) in WB
Western blot analysis of ESCO1 in Lane 1: MCF-7 whole cell lysate, Lane 2: Raw264.7 whole cell lysate, Lane 3: H9C2 whole cell lysate. Samples were incubated with ESCO1 polyclonal antibody (Product # PA5-37183) at a dilution of 1:500.
产品信息
PA5-37183
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to residues in human ESCO1
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2553947
产品详细信息
This antibody detects endogenous protein at a molecular weight of 95 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog1) or ESO1, is a member of the acetyltransferase family (GCN5 subfamily). It is a ubiquitously expressed nuclear protein that plays an important role in sister chromatid cohesion. At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo. Its N-terminus, containing two domains that are similar o alpha- and beta-type linker histone proteins, is essential for EFO1 association with chromosomes. EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTF7 homolog 1; ECO1 homolog 1; EFO1; EFO1p; ESO1 homolog 1; Establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; establisment of cohesion 1 homolog 1; hEFO1; N-acetyltransferase ESCO1; N-acetyltransferase ESCO1 variant 2
基因别名: A930014I12Rik; CTF; ECO1; EFO1; ESCO1; ESO1; KIAA1911
UniProt ID: (Human) Q5FWF5, (Mouse) Q69Z69
Entrez Gene ID: (Human) 114799, (Mouse) 77805, (Rat) 680014
