Search Thermo Fisher Scientific
- Contáctenos
- Orden Rápida
-
¿No tiene una cuenta? Crear una cuenta
Search Thermo Fisher Scientific
Immunogen sequence: VAAGVKKSG PLPSAERLEN VLFGPHDCSH APPDGYPIIP TSGSVPVQKQ ASLFPDEKED NLLGTTCLIA TAVITLFNEP SAEDSKKGPL TVAQKKAQNI MESFENPFRM FLPSLGHRAP VSQAAKFDPS TKIYEISNRW KLAQVQVQKD SKEAVKKKAA EQTAAREQAK EACKAAAEQA ISVRQQVVLE NAAKKRERAT SDPRTTEQKQ EKKRLKISKK PKDPEPPEKE FTPYDYSQSD FKAFAGNSKS KVSSQFDPNK QTPSGKKCIA AKKIKQSVGN KSMSFPTGKS DRGFRYNWPQ R (586-885 aa encoded by BC039901)
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: autoantigen PM-SCL; Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; Exosome complex component 10; exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog
Gene Aliases: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
UniProt ID: (Human) Q01780, (Mouse) P56960
Entrez Gene ID: (Human) 5394, (Mouse) 50912
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support