Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-58534
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EYA4. Recombinant protein control fragment (Product #RP-94980).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2641180
Product Specific Information
Immunogen sequence: QYAQYYSAST YGAYMTSNNT ADGTPSSTST YQLQESLPGL TNQPGEFDTM QSPSTPIKDL DERTCRSSGS KS
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: dJ78N10.1 (eyes absent); Eyes absent homolog 4; eyes absent-like protein 4
Gene Aliases: B130023L16Rik; CMD1J; DFNA10; EYA4
UniProt ID: (Human) O95677, (Mouse) Q9Z191
Entrez Gene ID: (Human) 2070, (Rat) 292172, (Mouse) 14051
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
visual perception
sensory perception of sound
anatomical structure morphogenesis
covalent chromatin modification
peptidyl-tyrosine dephosphorylation
middle ear morphogenesis
inner ear development
cellular response to DNA damage stimulus
chromatin modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support