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Invitrogen
Epstein Barr Virus Nuclear Antigen 1 Polyclonal Antibody
Product Details
PA1-7497
Product Specifications
Species Reactivity
Virus
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant EBNA-1.
Conjugate
Unconjugated
Form
Liquid
Concentration
5 mg/mL
Purification
IgG fraction
Storage buffer
PBS, pH 7.2
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1017063
Product Specific Information
The PA1-7497 antibody detects Epstein-Barr nuclear antigen (EBNA-1).
PA1-7497 has been successfully used in ELISA. Potential applications for PA1-7497 include fluorescence microscopy and immunohistochemistry.
The PA1-7497 antibody was raised against recombinant EBNA-1.
Target Information
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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