Product References
An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone.
Experimental & molecular medicine
Lee E,Lee EA,Kong E,Chon H,Llaiqui-Condori M,Park CH,Park BY,Kang NR,Yoo JS,Lee HS,Kim HS,Park SH,Choi SW,Vestweber D,Lee JH,Kim P,Lee WS,Kim I
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to reveal that the normal-to-tumor vascular transition is spatiotemporally associated with GBM invasion and may be controlled by Tie2 activation via a novel mechanism of action.
Wed Feb 01 00:00:00 UTC 2023
CCL2-Mediated Stromal Interactions Drive Macrophage Polarization to Increase Breast Tumorigenesis.
International journal of molecular sciences
Archer M,Bernhardt SM,Hodson LJ,Woolford L,Van der Hoek M,Dasari P,Evdokiou A,Ingman WV
14-4801-82 was used in Immunohistochemistry to show that interactions between macrophages and fibroblasts regulated by CCL2 can promote an environment that may increase breast cancer risk, leading to enhanced early tumorigenesis.
Mon Apr 17 00:00:00 UTC 2023
Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland.
Breast cancer research : BCR
Krisanits BA,Schuster R,Randise J,Nogueira LM,Lane JT,Panguluri GA,Li H,Helke K,Cuitiño MC,Koivisto C,Spruill L,Ostrowski MC,Anderson SM,Turner DP,Findlay VJ
14-4801-82 was used in Immunohistochemistry to find that the receptor for AGE (RAGE) is required for AGE-mediated increases in epithelial cell migration and invasion.
Fri Oct 06 00:00:00 UTC 2023
Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators.
JCI insight
Nikolaou KC,Godbersen S,Manoharan M,Wieland S,Heim MH,Stoffel M
14-4801-82 was used in Immunohistochemistry to identify TRIM21 as a negative regulator of liver steatosis in NASH and provide mechanistic insights into an immunometabolic crosstalk that limits fatty acid synthesis and fructose metabolism during metabolic stress.
Wed Nov 08 00:00:00 UTC 2023
Immunomodulatory contribution of mast cells to the regenerative biomaterial microenvironment.
NPJ Regenerative medicine
Wang RM,Mesfin JM,Karkanitsa M,Ungerleider JL,Zelus E,Zhang Y,Kawakami Y,Kawakami Y,Kawakami T,Christman KL
14-4801-82 was used in Immunohistochemistry to investigate the role of mast cells in the regulation of the immune response to decellularized biomaterial scaffolds using a subcutaneous implant model.
Wed Sep 20 00:00:00 UTC 2023
Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis.
JCI insight
Bale S,Verma P,Yalavarthi B,Scarneo SA,Hughes P,Amin MA,Tsou PS,Khanna D,Haystead TA,Bhattacharyya S,Varga J
14-4801-82 was used in Immunohistochemistry to implicate TAK1 in the pathogenesis of SSc and identify targeted TAK1 inhibition using a small molecule as a potential strategy for the treatment of SSc and other fibrotic diseases.
Mon Jul 24 00:00:00 UTC 2023
Iron therapy mitigates chronic kidney disease progression by regulating intracellular iron status of kidney macrophages.
JCI insight
Patino E,Bhatia D,Vance SZ,Antypiuk A,Uni R,Campbell C,Castillo CG,Jaouni S,Vinchi F,Choi ME,Akchurin O
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to elucidate the role of macrophage iron status in kidney fibrosis and demonstrate that it is a potential therapeutic target.
Tue Jan 10 00:00:00 UTC 2023
Proanthocyanidins suppress NLRP3 inflammasome and M1 macrophage polarization to alleviate severe acute pancreatitis in mice.
Journal of biochemical and molecular toxicology
Sheng LP,Han CQ,Ling X,Guo XW,Lin R,Ding Z
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to indicate the anti-inflammatory properties of the PAs on SAP mice by decreasing ROS levels, suppressing NLRP3 inflammasome, and M1 macrophage polarization.
Wed Feb 01 00:00:00 UTC 2023
Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells.
Fluids and barriers of the CNS
Luo Y,Yao F,Shi Y,Zhu Z,Xiao Z,You X,Liu Y,Yu S,Tian D,Cheng L,Zheng M,Jing J
14-4801-82 was used in Immunohistochemistry to demonstrate that at 14 and 28 dpi, the expression of claudin-5 (CLDN5) and zonula occludens-1 (ZO-1) between vascular endothelial cells was significantly increased and the leakage of BSCB was significantly reduced in the injured core after daily intrathecal injection of Tocilizumab.
Mon Jan 09 00:00:00 UTC 2023
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.
Cancer nanotechnology
Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y
14-4801-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.
Tue Apr 25 00:00:00 UTC 2023
Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome.
Basic research in cardiology
Selejan SR,Linz D,Mauz M,Hohl M,Huynh AKD,Speer T,Wintrich J,Kazakov A,Werner C,Mahfoud F,Böhm M
14-4801-82 was used in Immunohistochemistry to investigate the effect of sympathetic modulation by renal denervation (RDN) on atrial remodeling, RAGE/sRAGE and RAGE ligands in metabolic syndrome.
Thu Jul 14 00:00:00 UTC 2022
A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling.
Nature communications
Yuan Q,Ren Q,Li L,Tan H,Lu M,Tian Y,Huang L,Zhao B,Fu H,Hou FF,Zhou L,Liu Y
14-4801-82 was used in Western Blot to screen for the ability of a series of synthesised peptides derived from human Klotho protein, an anti-aging protein, to inhibit TGF-β1-induced fibroblast activation.
Fri Jan 21 00:00:00 UTC 2022
MK2 Promotes the Development and Progression of Pancreatic Neuroendocrine Tumors Mediated by Macrophages and Metabolomic Factors.
International journal of molecular sciences
Jacenik D,Lebish EJ,Beswick EJ
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to identify MK2 as a potent driver of immune response and metabolic effectors in PNETs, suggesting it is a potential therapeutic target for patients with PNETs.
Sat Nov 05 00:00:00 UTC 2022
Liver-adipose tissue crosstalk in alcohol-associated liver disease: The role of mTOR.
Liver research
Rodriguez Y,Dunfield J,Roderique T,Ni HM
14-4801-82 was used in Immunohistochemistry-paraffin to demonstrate the critical role of adipocyte mTOR in regulating the adipose-liver crosstalk in ALD.
Thu Dec 01 00:00:00 UTC 2022
miR-379 mediates insulin resistance and obesity through impaired angiogenesis and adipogenesis regulated by ER stress.
Molecular therapy. Nucleic acids
Abdollahi M,Kato M,Lanting L,Tunduguru R,Wang M,Wang Y,Fueger PT,Wang Q,Huang W,Natarajan R
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to suggest that miR-379 plays an important role in HFD-induced obesity through increased adipose inflammation, mitochondrial dysfunction, and ER stress as well as impaired adipogenesis and angiogenesis.
Tue Dec 13 00:00:00 UTC 2022
Receptor of Advanced Glycation End Products Deficiency Attenuates Cisplatin-Induced Acute Nephrotoxicity by Inhibiting Apoptosis, Inflammation and Restoring Fatty Acid Oxidation.
Frontiers in pharmacology
Wang Q,Xi Y,Chen B,Zhao H,Yu W,Xie D,Liu W,He F,Xu C,Cheng J
14-4801-82 was used in Western Blotting to show that RAGE knockout mitigated cisplatin-induced acute nephrotoxicity by inhibiting apoptosis, inflammation, and restoring fatty acid oxidation in TECs, suggesting that RAGE inhibition could be a therapeutic option for cisplatin-induced acute nephrotoxicity.
Fri Dec 16 00:00:00 UTC 2022
Gut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury.
Microbiology spectrum
Zou YT,Zhou J,Zhu JH,Wu CY,Shen H,Zhang W,Zhou SS,Xu JD,Mao Q,Zhang YQ,Long F,Li SL
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to demonstrate that gut microbiota mediates the protective effects of traditional Chinese medicine formula Qiong-Yu-Gao against cisplatin-induced acute kidney injury.
Wed Jun 29 00:00:00 UTC 2022
Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer.
Cell death & disease
Chu L,Qu Y,An Y,Hou L,Li J,Li W,Fan G,Song BL,Li E,Zhang L,Qi W
14-4801-82 was used in Immunohistochemistry to unravel the pharmacological mechanism of PRC2 inhibitors and propose a combination strategy for MAK683 and other PRC2 drugs.
Tue Feb 15 00:00:00 UTC 2022
Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma.
Cell reports
Cortes JR,Filip I,Albero R,Patiño-Galindo JA,Quinn SA,Lin WW,Laurent AP,Shih BB,Brown JA,Cooke AJ,Mackey A,Einson J,Zairis S,Rivas-Delgado A,Laginestra MA,Pileri S,Campo E,Bhagat G,Ferrando AA,Rabadan R,Palomero T
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to study the specific role and mechanism of peripheral T cell lymphoma not otherwise specified (PTCL-NOS).
Tue Apr 19 00:00:00 UTC 2022
Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis.
Cell death & disease
Sun X,Ni Y,Lu Q,Liang Y,Gu M,Xue X,Dai C
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to study the impact of activated mTORC1 on the cell-cell interaction of KCs and hepatocyte in immune-mediated hepatitis.
Fri Dec 09 00:00:00 UTC 2022
Slc7a8 Deletion Is Protective against Diet-Induced Obesity and Attenuates Lipid Accumulation in Multiple Organs.
Biology
Pitere RR,van Heerden MB,Pepper MS,Ambele MA
14-4801-82 was used in Immunohistochemistry to demonstrate that targeting slc7a8 protects against diet-induced obesity by reducing lipid accumulation in multiple organs and suggests that if targeted, has the potential to mitigate the development of obesity-associated comorbidities.
Wed Feb 16 00:00:00 UTC 2022
Loss of Proximal Tubular Sirtuin 6 Aggravates Unilateral Ureteral Obstruction-Induced Tubulointerstitial Inflammation and Fibrosis by Regulation of β-Catenin Acetylation.
Cells
Jin J,Li W,Wang T,Park BH,Park SK,Kang KP
14-4801-82 was used in Immunohistochemistry to evaluate inflammatory cytokine and cell adhesion molecule expression after ureteral obstruction.
Wed Apr 27 00:00:00 UTC 2022
A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease.
Redox biology
Nagasaki T,Maeda H,Taguchi K,Yanagisawa H,Nishida K,Kobayashi K,Wada N,Noguchi I,Murata R,Sakai H,Kitagishi H,Saruwatari J,Watanabe H,Otagiri M,Maruyama T
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to show that CO-driven mtROS partially contributes to the upregulation of the aforementioned molecules in tubular cells.
Mon Aug 01 00:00:00 UTC 2022
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system.
Nature communications
Weigert A,Zheng X,Nenzel A,Turkowski K,Günther S,Strack E,Sirait-Fischer E,Elwakeel E,Kur IM,Nikam VS,Valasarajan C,Winter H,Wissgott A,Voswinkel R,Grimminger F,Brüne B,Seeger W,Pullamsetti SS,Savai R
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to provide evidence for a crucial role of fibrocytes in lung cancer progression and metastasis, suggesting targets for treatment strategies.
Fri Oct 14 00:00:00 UTC 2022
Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication.
Cell reports
Vu R,Jin S,Sun P,Haensel D,Nguyen QH,Dragan M,Kessenbrock K,Nie Q,Dai X
14-4801-82 was used in Immunocytochemistry-immunoflourescence to expose numerous cellular/molecular targets for functional interrogation and provides a hypothesis-generating resource for future wound healing studies.
Tue Aug 02 00:00:00 UTC 2022
Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs.
Nature communications
Wang W,Bale S,Wei J,Yalavarthi B,Bhattacharyya D,Yan JJ,Abdala-Valencia H,Xu D,Sun H,Marangoni RG,Herzog E,Berdnikovs S,Miller SD,Sawalha AH,Tsou PS,Awaji K,Yamashita T,Sato S,Asano Y,Tiruppathi C,Yeldandi A,Schock BC,Bhattacharyya S,Varga J
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to characterize the expression, function, and role of A20, and its negative transcriptional regulator DREAM, in patients with systemic sclerosis and disease models.
Wed Oct 26 00:00:00 UTC 2022
Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation.
Oxidative medicine and cellular longevity
Luo T,Zhou X,Qin M,Lin Y,Lin J,Chen G,Liu A,Ouyang D,Chen D,Pan H
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to demonstrate that corilagin suppressed the ROS/TXNIP/NLRP3 pathway to repress inflammasome activation and pyroptosis and suggest its potential antioxidative role in alleviating NLRP3-dependent gouty arthritis.
Fri Oct 28 00:00:00 UTC 2022
Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Du Y,Cao M,Liu Y,He Y,Yang C,Zhang G,Fan Y,Gao F
14-4801-82 was used in Immunohistochemistry (Paraffin) to study the crosstalk between HA in TME and macrophages dependent lymphangiogenesis.
Fri Apr 01 00:00:00 UTC 2022
A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice.
Journal of the American Society of Nephrology : JASN
Song CJ,Li Z,Ahmed UKB,Bland SJ,Yashchenko A,Liu S,Aloria EJ,Lever JM,Gonzalez NM,Bickel MA,Giles CB,Georgescu C,Wren JD,Lang ML,Benveniste EN,Harrington LE,Tsiokas L,George JF,Jones KL,Crossman DK,Agarwal A,Mrug M,Yoder BK,Hopp K,Zimmerman KA
14-4801-82 was used in Immunohistochemistry-immunofluorescence to identify in an unbiased manner modifier cells that may be influencing the differential rate of cyst growth in injured versus non-injured cilia mutant kidneys at a time of similar cyst severity by generating a single-cell atlas of cystic kidney disease.
Fri Apr 01 00:00:00 UTC 2022
In vitro and in vivo correlation of skin and cellular responses to nucleic acid delivery.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Bosnjak M,Znidar K,Sales Conniff A,Jesenko T,Markelc B,Semenova N,Tur J,Kohena K,Kranjc Brezar S,Heller L,Cemazar M
14-4801-82 was used in Immunohistochemistry-frozen immunofluorescence to investigate the immune response in skin cells, including keratinocytes, fibroblasts, and macrophages, following plasmid DNA electrotransfer, revealing upregulation of DNA sensors and cytokines.
Wed Jun 01 00:00:00 UTC 2022
Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation.
Cellular and molecular gastroenterology and hepatology
Foglia B,Sutti S,Cannito S,Rosso C,Maggiora M,Autelli R,Novo E,Bocca C,Villano G,Ramavath NN,Younes R,Tusa I,Rovida E,Pontisso P,Bugianesi E,Albano E,Parola M
14-4801-82 was used immunohistochemistry (paraffin) investigate the involvement of hepatocyte HIF-2α in experimental nonalcoholic steatohepatitis (NASH)-related carcinogenesis.
Mon Apr 04 00:00:00 UTC 2022
Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics.
Developmental cell
Liang Y,Kaneko K,Xin B,Lee J,Sun X,Zhang K,Feng GS
14-4801-82 was used in Immunohistochemistry-immunofluorescence to provide a comprehensive atlas that covers all hepatic cell types and is instrumental for further dissection of liver development, metabolism, and disease.
Mon Feb 07 00:00:00 UTC 2022
Identification of macrophages in normal and injured mouse tissues using reporter lines and antibodies.
Scientific reports
Chen B,Li R,Kubota A,Alex L,Frangogiannis NG
14-4801-82 was used in Immunohistochemistry-immunofluorescence to identify macrophages with labeling.
Wed Mar 16 00:00:00 UTC 2022
Periosteal CD68+ F4/80+ Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF-β1.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Deng R,Li C,Wang X,Chang L,Ni S,Zhang W,Xue P,Pan D,Wan M,Deng L,Cao X
14-4801-82 was used in Immunohistochemistry-frozen immunofluorescence to suggest that periosteal myeloid-lineage cells respond to mechanical forces and consequently produce and activate TGF-β1 for periosteal bone formation.
Sat Jan 01 00:00:00 UTC 2022
Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jin L,Yu B,Liu G,Nie W,Wang J,Chen J,Xiao L,Xia H,Han F,Yang Y
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to demonstrate that mitophagy activation protected against renal fibrosis through improving mitochondrial fitness, downregulating TGF-β1/Smad signaling and alleviating TEC injuries and inflammatory infiltration in kidneys.
Wed Jun 01 00:00:00 UTC 2022
Sulforaphane recovers cone function in an Nrf2-dependent manner in middle-aged mice undergoing RPE oxidative stress.
Molecular vision
Qi X,Walton DA,Plafker KS,Boulton ME,Plafker SM
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to highlight the capacity of Sulforaphane (SFN) to preserve cone function, as well as the potential challenges of using the compound as a standalone treatment for age-related retinal degeneration under conditions associated with reduced Nrf2 function.
Tue Nov 08 00:00:00 UTC 2022
Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells.
Cellular & molecular immunology
Yu M,Pan H,Che N,Li L,Wang C,Wang Y,Ma G,Qian M,Liu J,Zheng M,Xie H,Ling L,Zhao Y,Guan X,Ding Q,Zhou W,Wang S
14-4801-82 was used in Immunohistochemistry to demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis, and MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer.
Wed Sep 01 00:00:00 UTC 2021
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes.
Science translational medicine
Wang X,Maxwell KG,Wang K,Bowers DT,Flanders JA,Liu W,Wang LH,Liu Q,Liu C,Naji A,Wang Y,Wang B,Chen J,Ernst AU,Melero-Martin JM,Millman JR,Ma M
14-4801-82 was used in Immunohistochemistry to design a safe and functional device composed of a highly porous, durable nanofibrous skin and an immunoprotective hydrogel core.
Wed Jun 02 00:00:00 UTC 2021
Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis.
Stem cells (Dayton, Ohio)
Pouyanfard S,Meshgin N,Cruz LS,Diggle K,Hashemi H,Pham TV,Fierro M,Tamayo P,Fanjul A,Kisseleva T,Kaufman DS
14-4801-82 was used in Immunohistochemistry to demonstrate that treatment of liver fibrosis with both human iPSC-derived macrophage populations and especially M2 subtype significantly reduces fibrogenic gene expression and disease associated histological markers including Sirius Red, αSMA and desmin in immunodeficient Rag2-/- γc-/- mice model, making this approach a promising cell-based avenue to ameliorate fibrosis.
Wed Dec 01 00:00:00 UTC 2021
Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo.
The American journal of pathology
Li M,McGhee EM,Shinno L,Lee K,Lin YL
14-4801-82 was used in Immunohistochemistry to show that butyrate treatment changed the property of HPV16 E6/E7-immortalized keratinocytes.
Fri Oct 01 00:00:00 UTC 2021
Targeting the Cholecystokinin Receptor: A Novel Approach for Treatment and Prevention of Hepatocellular Cancer.
Cancer prevention research (Philadelphia, Pa.)
Gay MD,Safronenka A,Cao H,Liu FH,Malchiodi ZX,Tucker RD,Kroemer A,Shivapurkar N,Smith JP
14-4801-82 was used in Immunohistochemistry (Paraffin) to to reveal staining of human HCC and no staining in normal liver.
Fri Jan 01 00:00:00 UTC 2021
Potential functions of embryonic cardiac macrophages in angiogenesis, lymphangiogenesis and extracellular matrix remodeling.
Histochemistry and cell biology
Gula G,Rumiński S,Niderla-Bielińska J,Jasińska A,Kiernozek E,Jankowska-Steifer E,Flaht-Zabost A,Ratajska A
14-4801 was used in Immunohistochemistry to characterize cardiac tissue macrophages populations and their potential functions based on surface markers.
Fri Jan 01 00:00:00 UTC 2021
Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease.
Nature communications
Ding H,Li LX,Harris PC,Yang J,Li X
14-4801-82 was used in Functional assay to show that cystic cell derived extracellular vesicles and urinary exosomes derived from ADPKD patients promote cyst growth in Pkd1 mutant kidneys and in 3D cultures.
Tue Jul 27 00:00:00 UTC 2021
Caffeine Inhibits Choroidal Neovascularization Through Mitigation of Inflammatory and Angiogenesis Activities.
Frontiers in cell and developmental biology
Sorenson CM,Song YS,Zaitoun IS,Wang S,Hanna BA,Darjatmoko SR,Gurel Z,Fisk DL,McDowell CM,McAdams RM,Sheibani N
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Sample Prep to demonstrate an important role for expression of AR in the choroid whose antagonism mitigate choroidal inflammatory and angiogenesis activities.
Fri Jan 07 00:00:00 UTC 2022
A combination of pirfenidone and TGF-β inhibition mitigates cystic echinococcosis-associated hepatic injury.
Parasitology
Wang E,Liao Z,Wang L,Liao Y,Xu X,Liu P,Wang X,Hou J,Jiang H,Wu X,Chen X
14-4801-82 was used in Immunohistochemistry to reveal that the inhibitory receptors on the surface of liver NK cells were up-regulated, whereas the activating receptors were down-regulated over time.
Tue Jun 01 00:00:00 UTC 2021
A combination of pirfenidone and TGF-β inhibition mitigates cystic echinococcosis-associated hepatic injury.
Parasitology
Wang E,Liao Z,Wang L,Liao Y,Xu X,Liu P,Wang X,Hou J,Jiang H,Wu X,Chen X
14-4801-82 was used in Immunohistochemistry to reveal that the inhibitory receptors on the surface of liver NK cells were up-regulated, whereas the activating receptors were down-regulated over time.
Tue Jun 01 00:00:00 UTC 2021
Connectivity Mapping Identifies BI-2536 as a Potential Drug to Treat Diabetic Kidney Disease.
Diabetes
Zhang L,Wang Z,Liu R,Li Z,Lin J,Wojciechowicz ML,Huang J,Lee K,Ma'ayan A,He JC
14-4801-81 was used in Immunohistochemistry (Paraffin) to suggest that the PLK1 inhibitor BI-2536 should be further investigated as a novel therapy for DKD.
Mon Feb 01 00:00:00 UTC 2021
Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.
Biology
Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR
14-4801-82 was used in Immunohistochemistry (Frozen) to investigate the correlation between interleukin 16 levels and neuroinflammation severity using an experimental autoimmune encephalomyelitis mouse model.
Thu May 27 00:00:00 UTC 2021
Garlic Essential Oil as Promising Option for the Treatment of Acute Campylobacteriosis-Results from a Preclinical Placebo-Controlled Intervention Study.
Microorganisms
Heimesaat MM,Mousavi S,Weschka D,Bereswill S
14-4801-82 was used in Immunohistochemistry (Paraffin) to to study the antimicrobial and immune-modulatory effects of garlic essential oil as a potential therapy for campylobacteriosis.
Tue May 25 00:00:00 UTC 2021
Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.
Cell reports
Chen WS,Liang Y,Zong M,Liu JJ,Kaneko K,Hanley KL,Zhang K,Feng GS
14-4801-82 was used in Immunocytochemistry-immunoflourescence to elucidate complex mechanisms of liver tumorigenesis driven by cell-intrinsic oncogenic signaling in cooperation with a tumor-promoting microenvironment generated by disrupting the specific oncogenic pathway.
Tue Nov 09 00:00:00 UTC 2021
Anti-Pathogenic and Immune-Modulatory Effects of Peroral Treatment with Cardamom Essential Oil in Acute Murine Campylobacteriosis.
Microorganisms
Heimesaat MM,Mousavi S,Weschka D,Bereswill S
14-4801-82 was used in Immunohistochemistry to provide the first evidence that cardamom EO comprises a promising compound for the combat of acute campylobacteriosis and presumably prevention of post-infectious morbidities.
Thu Jan 14 00:00:00 UTC 2021
The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.
iScience
Fu H,Gui Y,Liu S,Wang Y,Bastacky SI,Qiao Y,Zhang R,Bonin C,Hargis G,Yu Y,Kreutzer DL,Biswas PS,Zhou Y,Wang Y,Tian XJ,Liu Y,Zhou D
14-4801-82 was used in Flow Cytometry to validate that loss of c-met influences epithelial plasticity, myofibroblast activation, and extracellular matrix synthesis/degradation, which ultimately determined the characteristics of the fibrotic KLM.
Fri Oct 22 00:00:00 UTC 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
14-4801-82 was used in Flow Cytometry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.
Tue Jun 01 00:00:00 UTC 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-4801-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 UTC 2020
Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution.
Gastroenterology
Liu X,Xu J,Rosenthal S,Zhang LJ,McCubbin R,Meshgin N,Shang L,Koyama Y,Ma HY,Sharma S,Heinz S,Glass CK,Benner C,Brenner DA,Kisseleva T
14-4801 was used in Immunohistochemistry to identify molecular features of phenotypes of HSCs from mice and humans.
Fri May 01 00:00:00 UTC 2020
Chronic mTOR activation induces a degradative smooth muscle cell phenotype.
The Journal of clinical investigation
Li G,Wang M,Caulk AW,Cilfone NA,Gujja S,Qin L,Chen PY,Chen Z,Yousef S,Jiao Y,He C,Jiang B,Korneva A,Bersi MR,Wang G,Liu X,Mehta S,Geirsson A,Gulcher JR,Chittenden TW,Simons M,Humphrey JD,Tellides G
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate the effects of smooth muscle cell proliferation in the aortic media by conditional disruption of Tsc1, which hyperactivates mTOR complex 1.
Mon Mar 02 00:00:00 UTC 2020
Methylation in pericytes after acute injury promotes chronic kidney disease.
The Journal of clinical investigation
Chou YH,Pan SY,Shao YH,Shih HM,Wei SY,Lai CF,Chiang WC,Schrimpf C,Yang KC,Lai LC,Chen YM,Chu TS,Lin SL
14-4801 was used in Immunohistochemistry-immunofluorescence to show chronic kidney disease can be prevented by inhibiting hypermethylation of pericytes after acute kidney injury.
Tue Sep 01 00:00:00 UTC 2020
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic acids research
Kong XY,Vik ES,Nawaz MS,Berges N,Dahl TB,Vågbø C,Suganthan R,Segers F,Holm S,Quiles-Jiménez A,Gregersen I,Fladeby C,Aukrust P,Bjørås M,Klungland A,Halvorsen B,Alseth I
14-4801 was used in Immunohistochemistry to investigate the in vivo function of Endonuclease V in mammals by generated a gene targeted Endonuclease V deficient mouse strain by homologous recombination.
Thu May 07 00:00:00 UTC 2020
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.
The Journal of experimental medicine
Arroyo EN,Pepper M
14-4801-82 was used in Flow Cytometry to study antigen-specific CD4+ T follicular helper (Tfh) cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.
Mon Feb 03 00:00:00 UTC 2020
Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Liu J,Kumar S,Heinzel A,Gao M,Guo J,Alvarado GF,Reindl-Schwaighofer R,Krautzberger AM,Cippà PE,McMahon J,Oberbauer R,McMahon AP
14-4801 was used in Immunocytochemistry-immunoflourescence to support further investigation in clinical model systems of the potential benefit from GDF15 administration in situations in which some level of tubular injury is inevitable, such as following a kidney transplant.
Wed Apr 01 00:00:00 UTC 2020
Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.
Journal of the American Society of Nephrology : JASN
Xu C,Wang L,Zhang Y,Li W,Li J,Wang Y,Meng C,Qin J,Zheng ZH,Lan HY,Mak KK,Huang Y,Xia Y
14-4801-81 was used in Immunocytochemistry to examine expression in mouse kidneys of MST1 and MST2, homologs of Hippo in Drosophila.
Fri May 01 00:00:00 UTC 2020
Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN.
Journal of the American Society of Nephrology : JASN
Antonelou M,Michaëlsson E,Evans RDR,Wang CJ,Henderson SR,Walker LSK,Unwin RJ,Salama AD
14-4801-82 was used in Immunohistochemistry to study the effects of a novel myeloperoxidase inhibitor, AZM198, on renal tissue in crescentic glomerulonephritis models.
Sat Feb 01 00:00:00 UTC 2020
Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis.
Autophagy
Pahari S,Negi S,Aqdas M,Arnett E,Schlesinger LS,Agrewala JN
14-4801-82 was used in Flow Cytometry to invesigate if a unique immunotherapeutic approach involving CLEC4E in conjunction with TLR4 to restrict the survival of mycobacterium tuberculosis through autophagy exists.
Mon Jun 01 00:00:00 UTC 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
14-4801-82 was used in Flow Cytometry to report a feature of skin Treg cells expanded by ultraviolet B (UVB) exposure.
Tue Aug 25 00:00:00 UTC 2020
Peptidase PepP is a novel virulence factor of Campylobacter jejuni contributing to murine campylobacteriosis.
Gut microbes
Heimesaat MM,Schmidt AM,Mousavi S,Escher U,Tegtmeyer N,Wessler S,Gadermaier G,Briza P,Hofreuter D,Bereswill S,Backert S
14-4801 was used in Immunohistochemistry to identify a peptidase of the M24 family as a potential novel virulence factor, which was named PepP.
Mon Nov 09 00:00:00 UTC 2020
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
14-4801 was used in Flow cytometry/Cell sorting to demonstrate how heme oxygenase 1 (HO-1) extrinsic activity prevents hematopoietic stem cells (HSCs) from premature exhaustion and may restore their function when aged.
Wed Feb 05 00:00:00 UTC 2020
Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
Liver international : official journal of the International Association for the Study of the Liver
Fuchs CD,Krivanec S,Steinacher D,Mlitz V,Wahlström A,Stahlman M,Claudel T,Scharnagl H,Stojakovic T,Marschall HU,Trauner M
14-4801 was used in Immunohistochemistry to test a hypothesis that changes in hepatic BA profile and subsequent changes in BA signalling may critically determine the susceptibility to steatohepatitis.
Mon Jun 01 00:00:00 UTC 2020
WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice.
Acta pharmacologica Sinica
Gao YS,Qian MY,Wei QQ,Duan XB,Wang SL,Hu HY,Liu J,Pan CY,Zhang SQ,Qi LW,Zhou JP,Zhang HB,Wang LR
14-4801 was used in Immunohistochemistry to develop novel ACC inhibitors and evaluate their therapeutic value for NASH prevention.
Sun Mar 01 00:00:00 UTC 2020
Zika Virus Mucosal Infection Provides Protective Immunity.
Journal of virology
Martínez LE,Garcia G,Contreras D,Gong D,Sun R,Arumugaswami V
14-4801-81 was used in Immunohistochemistry (Frozen) to demonstrate the protective effect of mucosal rectal immunization using an attenuated ZIKV strain.
Thu Apr 16 00:00:00 UTC 2020
Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression.
Molecular cancer research : MCR
Sullivan C,Brown NE,Vasiliauskas J,Pathrose P,Starnes SL,Waltz SE
14-4801 was used in Immunohistochemistry to provide additional evidence that epithelial RON expression coordinates interactions between prostate tumor cells and macrophages to promote macrophage-mediated tumor cell growth.
Sat Aug 01 00:00:00 UTC 2020
Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model.
The American journal of pathology
Zhou Y,Xu M,Liu P,Liang B,Qian M,Wang H,Song X,Nyshadham P,Che L,Calvisi DF,Li F,Lin S,Chen X
14-4801-82 was used in Immunohistochemistry to indicate that mTORC2 signaling effectively regulates liver regeneration by inducing oval cell proliferation.
Wed Jul 01 00:00:00 UTC 2020
Anti-inflammatory effects of natural flavonoid diosmetin in IL-4 and LPS-induced macrophage activation and atopic dermatitis model.
International immunopharmacology
Lee DH,Park JK,Choi J,Jang H,Seol JW
14-4801-81 was used in Immunohistochemistry (Frozen) to demonstrate that diosmetin exhibits the inhibitory effect on AD, suggesting that diosmetin may be a potential therapeutic agent for this atopic disorder.
Tue Dec 01 00:00:00 UTC 2020
Cyclin-like proteins tip regenerative balance in the liver to favour cancer formation.
Carcinogenesis
Fifield BA,Talia J,Stoyanovich C,Elliott MJ,Bakht MK,Basilious A,Samsoondar JP,Curtis M,Stringer KF,Porter LA
14-4801-81 was used in Immunohistochemistry (Frozen) to report that elevation of Spy1 within the liver of a transgenic mouse model leads to enhanced spontaneous liver tumourigenesis.
Fri Jul 10 00:00:00 UTC 2020
Integrin-β1 is required for the renal cystogenesis caused by ciliary defects.
American journal of physiology. Renal physiology
Yoo M,Barisoni LMC,Lee K,Gusella GL
14-4801-81 was used in Immunohistochemistry (Paraffin) to indicate that integrin-β1 is also required for the renal cystogenesis caused by ciliary defects and point to integrin-β1-controlled pathways as common drivers of the disease and as possible targets to interfere with the cystogenesis caused by ciliary defects.
Fri May 01 00:00:00 UTC 2020
Activated macrophages are crucial during acute PM2.5 exposure-induced angiogenesis in lung cancer.
Oncology letters
Li R,Yang L,Jiang N,Wang F,Zhang P,Zhou R,Zhang J
14-4801-82 was used in Immunohistochemistry to investigate the role of macrophages in the PM2.5-induced angiogenesis of lung cancer.
Wed Jan 01 00:00:00 UTC 2020
Peripheral Nerve Microscopic Changes Related to Study Procedures: Two Nonclinical Case Studies.
Toxicologic pathology
Bangari DS,Pardo ID,Sellers R,Johnson JA,Ryan S,Thurberg BL
14-4801 was used in Immunohistochemistry to study peripheral nerve lesions in 2 nonclinical rodent case studies.
Wed Jan 01 00:00:00 UTC 2020
Mouse Models of Nonalcoholic Steatohepatitis: Head-to-Head Comparison of Dietary Models and Impact on Inflammation and Animal Welfare.
Gastroenterology research and practice
Kroh A,Ivanova V,Drescher H,Andruszkow J,Longerich T,Nolting J,Eickhoff R,Heise D,Rheinwalt KP,Neumann UP,Ulmer FT
14-4801 was used in Immunohistochemistry to identify HFD60 and WD as suitable NASH mouse models without a significant strain on animal welfare.
Mon Sep 28 00:00:00 UTC 2020
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection.
Nature microbiology
Rowe SE,Wagner NJ,Li L,Beam JE,Wilkinson AD,Radlinski LC,Zhang Q,Miao EA,Conlon BP
14-4801 was used in Immunohistochemistry to show that macrophages not only fail to efficiently kill phagocytosed Staphylococcus aureus, but also induce tolerance to multiple antibiotics.
Sat Feb 01 00:00:00 UTC 2020
Inflammatory Immune Responses and Gut Microbiota Changes Following Campylobacter coli Infection of IL-10-/- Mice with Chronic Colitis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Biesemeier N,Klove S,Weschka D,Mousavi S,Bereswill S
14-4801 was used in Immunohistochemistry to study gastrointestinal colonisation properties, gut microbiota changes and pro-inflammatory sequelae changes following C. coli infection and chronic colitis using a mouse model.
Sat Jul 11 00:00:00 UTC 2020
Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.
Kidney360
Zimmerman KA,Huang J,He L,Revell DZ,Li Z,Hsu JS,Fitzgibbon WR,Hazard ES,Hardiman G,Mrug M,Bell PD,Yoder BK,Saigusa T
14-4801 was used in Immunocytochemistry-immunoflourescence to suggest that Irf5 promotes inflammatory cytokine production in resident macrophages resulting in accelerated cystogenesis.
Sun Mar 01 00:00:00 UTC 2020
Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway.
Theranostics
Zhao SJ,Kong FQ,Jie J,Li Q,Liu H,Xu AD,Yang YQ,Jiang B,Wang DD,Zhou ZQ,Tang PY,Chen J,Wang Q,Zhou Z,Chen Q,Yin GY,Zhang HW,Fan J
14-4801 was used in Immunocytochemistry to show bone marrow stem cell osteogenic differentiation and M2-like polarization is promoted by macrophage MSR1-mediated activation of the PI3K/AKT/GSK3β/β-catenin pathway.
Fri Apr 02 00:00:00 UTC 2021
Orf Virus IL-10 and VEGF-E Act Synergistically to Enhance Healing of Cutaneous Wounds in Mice.
Journal of clinical medicine
Wise LM,Stuart GS,Jones NC,Fleming SB,Mercer AA
14-4801 was used in Immunohistochemistry to examine the effects of the VEGF-E and ovIL-10 combination on healing processes in a murine wound model.
Sat Apr 11 00:00:00 UTC 2020
Enhancing efficacy of gemcitabine in pancreatic patient-derived xenograft mouse models.
International journal of pharmaceutics: X
Inkoom A,Ndemazie N,Affram K,Smith T,Zhu X,Underwood P,Krishnan S,Ofori E,Han B,Trevino J,Agyare E
14-4801 was used in Immunohistochemistry to investigate methods to improve the systemic stability and anticancer activity of 4NSG.
Tue Dec 01 00:00:00 UTC 2020
Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.
The Journal of biological chemistry
Hohl M,Mayr M,Lang L,Nickel AG,Barallobre-Barreiro J,Yin X,Speer T,Selejan SR,Goettsch C,Erb K,Fecher-Trost C,Reil JC,Linz B,Ruf S,Hübschle T,Maack C,Böhm M,Sadowski T,Linz D
14-4801 was used in Immunohistochemistry to evaluate the effects of CatA overexpression on LV remodeling.
Fri Sep 04 00:00:00 UTC 2020
Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis.
Microorganisms
Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Giladi E,Bereswill S,Gozes I
14-4801 was used in Immunohistochemistry to provide evidence that NAP application constitutes a promising option to combat acute campylobacteriosis.
Tue May 26 00:00:00 UTC 2020
Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer.
Scientific reports
Smith T,Affram K,Nottingham EL,Han B,Amissah F,Krishnan S,Trevino J,Agyare E
14-4801 was used in Immunohistochemistry-immunofluorescence to develop a novel drug delivery system, solid lipid nanoparticle (SLN), capable of delivering high payload of 5-FU to treat CRC.
Mon Oct 12 00:00:00 UTC 2020
Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.
PloS one
Zhang M,Haughey M,Wang NY,Blease K,Kapoun AM,Couto S,Belka I,Hoey T,Groza M,Hartke J,Bennett B,Cain J,Gurney A,Benish B,Castiglioni P,Drew C,Lachowicz J,Carayannopoulos L,Nathan SD,Distler J,Brenner DA,Hariharan K,Cho H,Xie W
14-4801-82 was used in Immunohistochemistry to provide an anti-fibrotic strategy for targeting the Wnt/β-catenin pathway through RSPO3 blockade and support that OMP-131R10 could be an important therapeutic agent for fibrosis.
Tue Jul 07 00:00:00 UTC 2020
Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota.
Pathogens (Basel, Switzerland)
Kløve S,Genger C,Mousavi S,Weschka D,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry-immunofluorescence to conclude that pathogenic LOS might play an important role in inducing TLR4-dependent host immune responses upon C. coli infection, which needs to be further addressed in more detail.
Mon May 18 00:00:00 UTC 2020
Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis.
International journal of molecular sciences
Jin J,Wang T,Park W,Li W,Kim W,Park SK,Kang KP
14-4801 was used in Immunohistochemistry to investigate the protective effects of VP on UUO-induced renal tubulointerstitial inflammation and fibrosis and its regulation of the transforming growth factor-β1 (TGF-β1)/Smad signaling pathway.
Sat Oct 31 00:00:00 UTC 2020
m6A RNA methylation impacts fate choices during skin morphogenesis.
eLife
Xi L,Carroll T,Matos I,Luo JD,Polak L,Pasolli HA,Jaffrey SR,Fuchs E
14-4801 was used in Immunohistochemistry to study mouse skin embryogenesis to tackle m6A's functions and physiological importance.
Wed Aug 26 00:00:00 UTC 2020
Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
Science advances
Do-Umehara HC,Chen C,Zhang Q,Misharin AV,Abdala-Valencia H,Casalino-Matsuda SM,Reyfman PA,Anekalla KR,Gonzalez-Gonzalez FJ,Sala MA,Peng C,Wu P,Wong CCL,Kalhan R,Bharat A,Perlman H,Ridge KM,Sznajder JI,Sporn PHS,Chandel NS,Yu J,Fu X,Petrache I,Tuder R,Budinger GRS,Liu J
14-4801 was used in Immunohistochemistry to suggest that Miz1 down-regulation-induced sustained activation of NF-κB-dependent inflammation in the lung epithelium is sufficient to induce progressive lung and airway destruction that recapitulates features of COPD, with implications for COVID-19.
Sat Aug 01 00:00:00 UTC 2020
Microbiota composition and inflammatory immune responses upon peroral application of the commercial competitive exclusion product Aviguard® to microbiota-depleted wildtype mice.
European journal of microbiology & immunology
Heimesaat MM,Weschka D,Kløve S,Genger C,Biesemeier N,Mousavi S,Bereswill S
14-4801 was used in Immunohistochemistry to surveyed the intestinal bacterial colonization properties, potential macroscopic and microscopic inflammatory sequelae and immune responses upon peroral application of the commercial competitive exclusion product Aviguard® to wildtype mice in which the gut microbiota had been depleted by antibiotic pre-treatment.
Mon Jul 27 00:00:00 UTC 2020
Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection.
Science advances
Park MY,Kim HS,Lee HY,Zabel BA,Bae YS
14-4801-82 was used in Flow Cytometry to find a previously unidentified pathogenic CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection with Staphylococcus aureus.
Wed Jan 01 00:00:00 UTC 2020
Resveratrol Alleviates Acute Campylobacter jejuni Induced Enterocolitis in a Preclinical Murine Intervention Study.
Microorganisms
Heimesaat MM,Mousavi S,Escher U,Lobo de Sá FD,Peh E,Schulzke JD,Kittler S,Bücker R,Bereswill S
14-4801-82 was used in Immunohistochemistry to provides evidence that peroral resveratrol treatment exerts potent disease-alleviating effects during acute experimental campylobacteriosis.
Wed Nov 25 00:00:00 UTC 2020
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.
Nature metabolism
Brett JO,Arjona M,Ikeda M,Quarta M,de Morrée A,Egner IM,Perandini LA,Ishak HD,Goshayeshi A,Benjamin DI,Both P,Rodríguez-Mateo C,Betley MJ,Wyss-Coray T,Rando TA
14-4801 was used in Immunohistochemistry to investigate the effect of exercise on aged stem cell function in the context of tissue regeneration in old mice.
Wed Apr 01 00:00:00 UTC 2020
Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics.
Cell reports
Haensel D,Jin S,Sun P,Cinco R,Dragan M,Nguyen Q,Cang Z,Gong Y,Vu R,MacLean AL,Kessenbrock K,Gratton E,Nie Q,Dai X
14-4801 was used in Immunohistochemistry to identify three non-proliferative and one proliferative basal cell state in homeostatic skin that differ in metabolic preference and become spatially partitioned during wound re-epithelialization.
Tue Mar 17 00:00:00 UTC 2020
Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs.
Genes
Scherer A,Stephens VR,McGivney GR,Gutierrez WR,Laverty EA,Knepper-Adrian V,Dodd RD
14-4801 was used in Immunohistochemistry to highlight important strain-specific phenotypes of genomically-matched malignant peripheral nerve sheath tumors (MPNSTs) that have implications for the design of future studies using similar in vivo gene editing approaches.
Sat May 23 00:00:00 UTC 2020
Effects of stanniocalcin-1 overexpressing hepatocellular carcinoma cells on macrophage migration.
PloS one
Leung CCT,Wong CKC
14-4801-81 was used in Immunohistochemistry (Paraffin) to demonstrate the inhibitory effect of STC1-overexpressing cancer cells on macrophage migration/infiltration.
Mon Jan 11 00:00:00 UTC 2021
Toll-Like Receptor-4 Is Involved in Mediating Intestinal and Extra-Intestinal Inflammation in Campylobacter coli-Infected Secondary Abiotic IL-10-/- Mice.
Microorganisms
Kløve S,Genger C,Weschka D,Mousavi S,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to provide evidence that TLR4 is involved in mediating C. coli-LOS-induced immune responses in intestinal and extra-intestinal compartments during murine campylobacteriosis.
Fri Nov 27 00:00:00 UTC 2020
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Nature communications
Lee JY,Han SH,Park MH,Song IS,Choi MK,Yu E,Park CM,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS
14-4801 was used in Flow cytometry/Cell sorting to identify a role of N-AS in the dysfunction of microglia in AD.
Tue May 12 00:00:00 UTC 2020
A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer.
Science advances
Li HM,Bi YR,Li Y,Fu R,Lv WC,Jiang N,Xu Y,Ren BX,Chen YD,Xie H,Wang S,Lu T,Wu ZQ
14-4801 was used in Immunohistochemistry-immunofluorescence to describe the inhibition of Snail by CYD19 in wild-type p53-expressing cancer.
Wed Apr 01 00:00:00 UTC 2020
Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Neoplasia (New York, N.Y.)
Gupta S,Prajapati A,Gulati M,Gautam SK,Kumar S,Dalal V,Talmon GA,Rachagani S,Jain M
14-4801 was used in Immunohistochemistry-immunofluorescence to show chronic and acute pancreatic inflammation with oncogenic K-ras presence mediates irreversible and sustained upregulation of endothelin axis.
Sat Feb 01 00:00:00 UTC 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
14-4801 was used in Immunohistochemistry to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 UTC 2020
Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model.
Nutrients
Jung DH,Park MH,Kim CJ,Lee JY,Keum CY,Kim IS,Yun CH,Kim SK,Kim WH,Lee YC
14-4801 was used in Immunohistochemistry to investigate the effects of H-002119-00-001 from β-caryophyllene on the eradication of H. pylori in a mouse model, and its effects on the inflammation of the gastric mucosa.
Sat Apr 04 00:00:00 UTC 2020
The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Klove S,Weschka D,Mousavi S,Bereswill S
14-4801-82 was used in Immunohistochemistry to survey the impact of the host-specific intestinal microbiota composition during peroral C. coli infection applying an established murine campylobacteriosis model.
Tue Sep 29 00:00:00 UTC 2020
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
Gastroenterology
Liang S,Ma HY,Zhong Z,Dhar D,Liu X,Xu J,Koyama Y,Nishio T,Karin D,Karin G,Mccubbin R,Zhang C,Hu R,Yang G,Chen L,Ganguly S,Lan T,Karin M,Kisseleva T,Brenner DA
14-4801 was used in Immunohistochemistry to study the functions of different NOX proteins in mice following administration of a liver carcinogen.
Fri Mar 01 00:00:00 UTC 2019
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.
Science translational medicine
Yang YM,Noureddin M,Liu C,Ohashi K,Kim SY,Ramnath D,Powell EE,Sweet MJ,Roh YS,Hsin IF,Deng N,Liu Z,Liang J,Mena E,Shouhed D,Schwabe RF,Jiang D,Lu SC,Noble PW,Seki E
14-4801 was used in Immunohistochemistry to provide evidence that HAS2 actively synthesizes hyaluronan (HA) in hepatic stellate cells (HSCs) and that it promotes HSC activation and liver fibrosis through Notch1.
Wed Jun 12 00:00:00 UTC 2019
NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD.
Hepatology (Baltimore, Md.)
Ohashi K,Wang Z,Yang YM,Billet S,Tu W,Pimienta M,Cassel SL,Pandol SJ,Lu SC,Sutterwala FS,Bhowmick N,Seki E
14-4801-81 was used in Immunohistochemistry (Paraffin) to conclude that in nonalcoholic fatty liver disease, NOD-like receptor C4 promotes metastatic liver tumour growth through M2 polarization, IL-1β, and VEGF production in tumour-associated macrophages.
Fri Nov 01 00:00:00 UTC 2019
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Journal of the American Society of Nephrology : JASN
Zimmerman KA,Song CJ,Li Z,Lever JM,Crossman DK,Rains A,Aloria EJ,Gonzalez NM,Bassler JR,Zhou J,Crowley MR,Revell DZ,Yan Z,Shan D,Benveniste EN,George JF,Mrug M,Yoder BK
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate the role of resident macrophages during rapid cyst progression in mice.
Tue Oct 01 00:00:00 UTC 2019
Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
EMBO molecular medicine
Thilakasiri P,Huynh J,Poh AR,Tan CW,Nero TL,Tran K,Parslow AC,Afshar-Sterle S,Baloyan D,Hannan NJ,Buchert M,Scott AM,Griffin MD,Hollande F,Parker MW,Putoczki TL,Ernst M,Chand AL
14-4801-82 was used in Flow Cytometry to establish the in vivo utility of bazedoxifene, a steroid analog clinically approved for the treatment of osteoporosis, to suppress gp130-dependent tumor growth of the gastrointestinal epithelium.
Mon Apr 01 00:00:00 UTC 2019
Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression.
Cancer research
Wettersten HI,Weis SM,Pathria P,Von Schalscha T,Minami T,Varner JA,Cheresh DA
14-4801 was used in Immunofluorescence on frozen tissues to suggest that anti-αvβ3 represents a promising immunotherapeutic approach to redirect TAMs to serve as tumor killers for late-stage or drug-resistant cancers.
Tue Oct 01 00:00:00 UTC 2019
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.
Experimental & molecular medicine
Zheng X,Zhang A,Binnie M,McGuire K,Webster SP,Hughes J,Howie SEM,Mole DJ
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to determine whether mice lacking kynurenine 3-monooxygenase activity are protected against acute kidney injury after renal ischemia-reperfusion injury.
Wed Feb 13 00:00:00 UTC 2019
Macrophages protect against loss of adipose tissue during cancer cachexia.
Journal of cachexia, sarcopenia and muscle
Erdem M,Möckel D,Jumpertz S,John C,Fragoulis A,Rudolph I,Wulfmeier J,Springer J,Horn H,Koch M,Lurje G,Lammers T,Olde Damink S,van der Kroft G,Gremse F,Cramer T
14-4801 was used in Immunohistochemistry-immunofluorescence to show macrophages can protect against cancer-induced adipose tissue wasting.
Tue Oct 01 00:00:00 UTC 2019
Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes.
The Journal of investigative dermatology
Moos S,Mohebiany AN,Waisman A,Kurschus FC
14-4801 was used in Immunohistochemistry-immunofluorescence to study if keratinocytes are a critical cellular target for IL-17A mediated neutrophil attraction and psoriasis development.
Wed May 01 00:00:00 UTC 2019
The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Dowling JK,Tate MD,Rosli S,Bourke NM,Bitto N,Lauterbach MA,Cheung S,Ve T,Kobe B,Golenbock D,Mansell A
14-4801-82 was used in Flow Cytometry to investigate the role MyD88 adaptor-like protein plays in regulating optimal TLR-induced inflammatory signaling pathways.
Mon Apr 15 00:00:00 UTC 2019
Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model.
Gut pathogens
Schmidt AM,Escher U,Mousavi S,Tegtmeyer N,Boehm M,Backert S,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to study the immunopathlogical characteristics of Campylobacter jejuni and determine the role of virulence factors FlaA and FlaB and adhesin CadF.
Fri Apr 08 00:00:00 UTC 2022
Maternal Glucocorticoids Make the Fetal Membrane Thinner: Involvement of Amniotic Macrophages.
Endocrinology
Kiyokawa H,Mogami H,Ueda Y,Kawamura Y,Sato M,Chigusa Y,Mandai M,Kondoh E
14-4801 was used in Immunohistochemistry-immunofluorescence to study the mechanism of how glucocorticoids weaken the fetal membranes.
Mon Apr 01 00:00:00 UTC 2019
A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.
Journal of mammary gland biology and neoplasia
Pénzváltó Z,Chen JQ,Tepper CG,Davis RR,Silvestrini MT,Umeh-Garcia M,Sweeney C,Borowsky AD
14-4801-82 was used in Immunohistochemistry to show that the NDLUCD cells have, so far, remained genetically and phenotypically stable over many generations, with consistent and reproducible results in immune intact preclinical cohorts.
Sat Jun 01 00:00:00 UTC 2019
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
PLoS genetics
Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F
14-4801-82 was used in Flow Cytometry to describe a shift in identity of muscle stem cells dependent on the crosstalk between MΦs and SCs.
Tue Oct 01 00:00:00 UTC 2019
Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts.
Journal of the American Society of Nephrology : JASN
Ishikawa Y,Fedeles S,Marlier A,Zhang C,Gallagher AR,Lee AH,Somlo S
14-4801-82 was used in Immunohistochemistry to explore the renal effects of postnatal inactivation of Sec63 alone or with concomitant inactivation of Xbp1 or Ire1α, specifically in the collecting ducts of neonatal mice.
Fri Mar 01 00:00:00 UTC 2019
Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
eLife
Carpentier KS,Davenport BJ,Haist KC,McCarthy MK,May NA,Robison A,Ruckert C,Ebel GD,Morrison TE
14-4801-82 was used in Flow Cytometry to reveal a previously unrecognized innate immune pathway that controls alphavirus viremia and dissemination in vertebrate hosts, ultimately influencing disease severity and likely transmission efficiency.
Wed Oct 09 00:00:00 UTC 2019
miR-511-3p protects against cockroach allergen-induced lung inflammation by antagonizing CCL2.
JCI insight
Do DC,Mu J,Ke X,Sachdeva K,Qin Z,Wan M,Ishmael FT,Gao P
14-4801 was used in Immunohistochemistry to identify how miR-511-3p regulates allergic inflammation and macrophage polarisation by inhibiting Ccl2 and its downstream Ccr2/RhoA downstream axis.
Thu Oct 17 00:00:00 UTC 2019
Comprehensive Kinetic Survey of Intestinal, Extra-Intestinal and Systemic Sequelae of Murine Ileitis Following Peroral Low-Dose Toxoplasma gondii Infection.
Frontiers in cellular and infection microbiology
Heimesaat MM,Dunay IR,Bereswill S
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to study the long-term intestinal and extra-intestinal sequelae of Toxoplasma gondii infection.
Mon Dec 09 00:00:00 UTC 2019
The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity.
JCI insight
Billi AC,Gharaee-Kermani M,Fullmer J,Tsoi LC,Hill BD,Gruszka D,Ludwig J,Xing X,Estadt S,Wolf SJ,Rizvi SM,Berthier CC,Hodgin JB,Beamer MA,Sarkar MK,Liang Y,Uppala R,Shao S,Zeng C,Harms PW,Verhaegen ME,Voorhees JJ,Wen F,Ward NL,Dlugosz AA,Kahlenberg JM,Gudjonsson JE
14-4801 was used in Immunohistochemistry to demonstrate that skin-targeted overexpression of the female-biased factor VGLL3 is sufficient to drive cutaneous and systemic autoimmune disease that is strikingly similar to SLE.
Thu Apr 18 00:00:00 UTC 2019
Eradication of unresectable liver metastasis through induction of tumour specific energy depletion.
Nature communications
Huo D,Zhu J,Chen G,Chen Q,Zhang C,Luo X,Jiang W,Jiang X,Gu Z,Hu Y
14-4801-82 was used in Flow Cytometry to assess the underlying molecular mechanism at both gene and protein levels to better understand the therapeutic outcome.
Thu Jul 11 00:00:00 UTC 2019
A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.
Scientific reports
Lee SK,Bae GH,Kim YS,Kim HS,Lee M,Ghim J,Zabel BA,Ryu SH,Bae YS
14-4801-82 was used in Flow Cytometry to investigate acetaminophen-induced acute liver injury treatment.
Fri May 10 00:00:00 UTC 2019
Epithelial innate immunity mediates tubular cell senescence after kidney injury.
JCI insight
Jin H,Zhang Y,Ding Q,Wang SS,Rastogi P,Dai DF,Lu D,Purvis M,Cao C,Wang A,Liu D,Ren C,Elhadi S,Hu MC,Chai Y,Zepeda-Orozco D,Campisi J,Attanasio M
14-4801-82 was used in Immunohistochemistry to reveal a cell-autonomous role for epithelial innate immunity in controlling TEC senescence after kidney injury, and additionally suggest that early therapeutic intervention is required for effective reduction of long-term sequelae of AKI.
Thu Jan 24 00:00:00 UTC 2019
Murine Fecal Microbiota Transplantation Alleviates Intestinal and Systemic Immune Responses in Campylobacter jejuni Infected Mice Harboring a Human Gut Microbiota.
Frontiers in immunology
Heimesaat MM,Mrazek K,Bereswill S
14-4801 was used in Immunohistochemistry to provide evidence that changes in the gut microbiota composition which might be achieved by pre- or probiotic formulations may effectively lower intestinal C. jejuni loads, dampen both, pathogen-induced intestinal and systemic inflammatory sequelae.
Mon Oct 26 00:00:00 UTC 2020
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.
Nature communications
Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G
14-4801-82 was used in Flow Cytometry to demonstrate that respiratory complex I-deficient tumours survive and carry out angiogenesis, despite their inability to stabilise Hypoxia Inducible Factor-1 alpha.
Fri Feb 22 00:00:00 UTC 2019
O-GlcNAc transferase suppresses necroptosis and liver fibrosis.
JCI insight
Zhang B,Li MD,Yin R,Liu Y,Yang Y,Mitchell-Richards KA,Nam JH,Li R,Wang L,Iwakiri Y,Chung D,Robert ME,Ehrlich BE,Bennett AM,Yu J,Nathanson MH,Yang X
14-4801 was used in Immunohistochemistry to report that O-linked β-N-acetylglucosamine (O-GlcNAc) modification protects against hepatocyte necroptosis and initiation of liver fibrosis.
Fri Nov 01 00:00:00 UTC 2019
Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice.
Frontiers in cellular and infection microbiology
Schmidt AM,Escher U,Mousavi S,Boehm M,Backert S,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to investigate whether the protease activity of HtrA has an impact in Campylobacter jejuni induced acute enterocolitis.
Fri Dec 06 00:00:00 UTC 2019
A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma.
Journal of clinical medicine
Kurelac I,Abarrategi A,Ragazzi M,Iommarini L,Umesh Ganesh N,Snoeks T,Bonnet D,Porcelli AM,Malanchi I,Gasparre G
14-4801 was used in Immunohistochemistry to characterize the tumour microenvironment of mitochondrial complex I deficient tumors in a model that represents osteosarcoma development.
Wed Dec 11 00:00:00 UTC 2019
Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Campylobacter jejuni Induced Enterocolitis Model.
Frontiers in immunology
Mousavi S,Lobo de Sá FD,Schulzke JD,Bücker R,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to show that synthetic 25-OH-cholecalciferol injected perorally, acts as an anti-inflammatory during acute campylobacteriosis.
Mon Nov 09 00:00:00 UTC 2020
Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors.
Nature communications
Duan X,Chan C,Han W,Guo N,Weichselbaum RR,Lin W
14-4801 was used in Flow cytometry/Cell sorting to conclude that the intrinsically biodegradable, well tolerated, and systemically available immunostimulatory NCP promises to enter clinical testing as an immunotherapy against colorectal cancer.
Tue Apr 23 00:00:00 UTC 2019
Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology
Ban Y,Dong W,Zhang L,Zhou T,Altiti AS,Ali K,Mootoo DR,Blaho VA,Hla T,Ren Y,Ma X
14-4801 was used in Flow cytometry/Cell sorting to reveal a novel pathway from the presentation of Mye-GalCer to IL-17 production, and highlight the promising therapeutic potential of D-sphingosine for the human disorder of multiple sclerosis.
Tue Jul 14 00:00:00 UTC 2020
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-4801 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 UTC 2021
TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP.
Cell death & disease
Knop J,Spilgies LM,Rufli S,Reinhart R,Vasilikos L,Yabal M,Owsley E,Jost PJ,Marsh RA,Wajant H,Robinson MD,Kaufmann T,Wong WW
14-4801 was used in Flow cytometry/Cell sorting to support the targeting of TNFR2 specifically to reduce IL-18 release in XLP-2 patients and to reduce priming of the inflammasome components.
Fri Sep 20 00:00:00 UTC 2019
A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth.
Cell stem cell
Wang ECE,Dai Z,Ferrante AW,Drake CG,Christiano AM
14-4801-82 was used in Flow Cytometry to show that Oncostatin M, an IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain hair follicle stem cells quiescence.
Thu Apr 04 00:00:00 UTC 2019
A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation.
Nature communications
Cippà PE,Liu J,Sun B,Kumar S,Naesens M,McMahon AP
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate the immunological consequences of dysfunctional tissue repair following kidney injury and transplantation.
Mon Mar 11 00:00:00 UTC 2019
Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure.
Cell death & disease
Bittel M,Kremer AE,Stürzl M,Wirtz S,Stolzer I,Neurath MF,Ballon G,Günther C
14-4801-82 was used in Immunohistochemistry (Paraffin) to to uncover that transgenic expression of vFlip can cause severe liver injury in mice, culminating in multiple organ insufficiency and death.
Thu Nov 21 00:00:00 UTC 2019
The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability.
Frontiers in immunology
Ronin E,Lubrano di Ricco M,Vallion R,Divoux J,Kwon HK,Grégoire S,Collares D,Rouers A,Baud V,Benoist C,Salomon BL
14-4801-82 was used in Flow Cytometry to show that RelA, a key member of the NF-κB complex, is critical for Treg biology as it promotes both the generation of their effector phenotype and the maintenance of their identity.
Thu Oct 29 00:00:00 UTC 2020
TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes.
Frontiers in immunology
Wang G,Zhao H,Zheng B,Li D,Yuan Y,Han Q,Tian Z,Zhang J
14-4801-82 was used in Flow Cytometry to provide insight into the intrinsic mechanisms of TLR2-induced Mo/MΦ migration and mobility, as well as the interaction between macrophages and hepatocytes in resistance to Lm infection.
Thu Oct 15 00:00:00 UTC 2020
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain.
The Journal of clinical investigation
Bang S,Xie YK,Zhang ZJ,Wang Z,Xu ZZ,Ji RR
14-4801 was used in Immunohistochemistry to study the role of GPR37 in the regulation of macrophage phagocytosis and inflammatory pain resolution.
Wed Aug 01 00:00:00 UTC 2018
PAI1 mediates fibroblast-mast cell interactions in skin fibrosis.
The Journal of clinical investigation
Pincha N,Hajam EY,Badarinath K,Batta SPR,Masudi T,Dey R,Andreasen P,Kawakami T,Samuel R,George R,Danda D,Jacob PM,Jamora C
14-4801 was used in Immunohistochemistry to identify roles for plasminogen activator inhibitor type 1 in the multifactorial program of fibrogenesis that expand its functional repertoire beyond its canonical role in plasmin-dependent processes.
Tue May 01 00:00:00 UTC 2018
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival.
The Journal of clinical investigation
Bahmani B,Uehara M,Jiang L,Ordikhani F,Banouni N,Ichimura T,Solhjou Z,Furtmüller GJ,Brandacher G,Alvarez D,von Andrian UH,Uchimura K,Xu Q,Vohra I,Yilmam OA,Haik Y,Azzi J,Kasinath V,Bromberg JS,McGrath MM,Abdi R
14-4801 was used in Immunohistochemistry to synthesize a nanoparticle (NP) as a carrier of anti-CD3, and optimized the conjugation strategy to coat the NP surface with MECA79 mAb (MECA79-anti-CD3-NP) to enhance LN accumulation.
Thu Nov 01 00:00:00 UTC 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-4801 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 UTC 2018
Wnt/β-Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis.
Journal of the American Society of Nephrology : JASN
Feng Y,Ren J,Gui Y,Wei W,Shu B,Lu Q,Xue X,Sun X,He W,Yang J,Dai C
14-4801 was used in Immunofluorescence in immunohistochemistry on frozen tissues to investigate the role of Wnt/Β-catenin in regulating macrophage activation and the contribution thereof to kidney fibrosis.
Mon Jan 01 00:00:00 UTC 2018
Redirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis.
Journal of the American Society of Nephrology : JASN
Qiao X,Rao P,Zhang Y,Liu L,Pang M,Wang H,Hu M,Tian X,Zhang J,Zhao Y,Wang XM,Wang C,Yu H,Guo F,Cao Q,Wang Y,Wang YM,Zhang GY,Lee VW,Alexander SI,Zheng G,Harris DCH
14-4801 was used in Immunohistochemistry to suggest targeting Β-catenin/Foxo may be a novel therapeutic strategy in the treatment of fibrotic diseases that lead to organ failure.
Thu Feb 01 00:00:00 UTC 2018
Macrophage-Derived Neuropilin-2 Exhibits Novel Tumor-Promoting Functions.
Cancer research
Roy S,Bag AK,Dutta S,Polavaram NS,Islam R,Schellenburg S,Banwait J,Guda C,Ran S,Hollingsworth MA,Singh RK,Talmadge JE,Muders MH,Batra SK,Datta K
14-4801 was used in Immunocytochemistry-immunoflourescence to demonstrate that NRP2 is expressed during macrophage differentiation, is induced by tumour cells, and regulates phagocytosis in macrophages.
Mon Oct 01 00:00:00 UTC 2018
Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.
PLoS biology
Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B
14-4801 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.
Tue May 01 00:00:00 UTC 2018
Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.
Journal of virology
Shinde PV,Xu HC,Maney SK,Kloetgen A,Namineni S,Zhuang Y,Honke N,Shaabani N,Bellora N,Doerrenberg M,Trilling M,Pozdeev VI,van Rooijen N,Scheu S,Pfeffer K,Crocker PR,Tanaka M,Duggimpudi S,Knolle P,Heikenwalder M,Ruland J,Mak TW,Brenner D,Pandyra AA,Hoell JI,Borkhardt A,Häussinger D,Lang KS,Lang PA
14-4801 was used in Immunohistochemistry to indicate that TNF mediates the maintenance of CD169 cells and innate and adaptive immune activation during vesicular stomatitis virus (VSV) infection.
Thu Feb 01 00:00:00 UTC 2018
Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus.
Molecular therapy oncolytics
Burgess HM,Pourchet A,Hajdu CH,Chiriboga L,Frey AB,Mohr I
14-4801 was used in Immunohistochemistry to demonstrate that D9- or D10-deficient vaccinia viruses are effective oncolytic viruses.
Fri Mar 30 00:00:00 UTC 2018
Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Liu JT,Wu SX,Zhang H,Kuang F
14-4801 was used in Immunohistochemistry-immunofluorescence to characterise post-status epilepticus inflammation, and explore the role of myeloid differentiation primary response gene 88, in the induction of post-status epilepticus in a mouse model.
Mon Oct 01 00:00:00 UTC 2018
Interventional Potential of Recombinant Feline Hepatocyte Growth Factor in a Mouse Model of Non-alcoholic Steatohepatitis.
Frontiers in endocrinology
Yang YM,Fukui M,Wang Z,Miao F,Karriker MJ,Seki E
14-4801 was used in Immunohistochemistry to investigate the anti-inflammatory, anti-fibrotic, and anti-lipogenic effects of exogenous administration of feline HGF on a non-alcoholic steatohepatitis (NASH) mouse model.
Wed Nov 20 00:00:00 UTC 2019
Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Sheng L,Jena PK,Liu HX,Hu Y,Nagar N,Bronner DN,Settles ML,Bäumler AJ,Wan YY
14-4801 was used in Western Blotting to show epigallocatechin-3-gallate has a metabolic beneficial effect by influencing gut microbiota and regulating bile acid signaling.
Fri Jun 08 00:00:00 UTC 2018
Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain.
The FEBS journal
Robson JP,Wagner B,Glitzner E,Heppner FL,Steinkellner T,Khan D,Petritsch C,Pollak DD,Sitte HH,Sibilia M
14-4801 was used in Immunofluorescence in immunohistochemistry on frozen tissues to demonstrate that postnatal EGFR-deficient neural stem cells are impaired in their self-renewal potential and lack clonal expansion capacity in vitro.
Sat Sep 01 00:00:00 UTC 2018
Superoxide Production by NADPH Oxidase Intensifies Macrophage Antiviral Responses during Diabetogenic Coxsackievirus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Burg AR,Das S,Padgett LE,Koenig ZE,Tse HM
14-4801 was used in Flow cytometry/Cell sorting to investigate whether the loss of NADPH oxidase-derived superoxide dampens diabetogenic antiviral macrophage responses and protects against virus-induced diabetes.
Mon Jan 01 00:00:00 UTC 2018
The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.
Journal of immunology (Baltimore, Md. : 1950)
Hansell CAH,Fraser AR,Hayes AJ,Pingen M,Burt CL,Lee KM,Medina-Ruiz L,Brownlie D,Macleod MKL,Burgoyne P,Wilson GJ,Nibbs RJB,Graham GJ
14-4801 was used in Flow cytometry/Cell sorting to determine the role of Ackr2 in metastasis.
Mon Oct 15 00:00:00 UTC 2018
Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.
Journal of immunology (Baltimore, Md. : 1950)
Nyhoff LE,Clark ES,Barron BL,Bonami RH,Khan WN,Kendall PL
14-4801 was used in Flow cytometry/Cell sorting to raise the possibility that Btk may also be expendable for survival of mature human B cells, therefore requiring prolonged dosing to be effective, and that success of BTK inhibitors may depend in part on off-target effects.
Sun Apr 01 00:00:00 UTC 2018
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Ringleb J,Strack E,Angioni C,Geisslinger G,Steinhilber D,Weigert A,Brüne B
14-4801-82 was used in Immunohistochemistry to reveal that 5-LO, which is required for leukotriene production and subsequent T cell recruitment, is downregulated in TAMs through Mer tyrosine kinase-dependent recognition of apoptotic cancer cells.
Mon Jan 15 00:00:00 UTC 2018
Combination of paromomycin plus human anti-TNF-α antibodies to control the local inflammatory response in BALB/ mice with cutaneous leishmaniasis lesions.
Journal of dermatological science
Schwartz J,Moreno E,Calvo A,Blanco L,Fernández-Rubio C,Sanmartín C,Nguewa P,Irache JM,Larrea E,Espuelas S
14-4801 was used in Immunohistochemistry to investigate if anti-TNF-α antibodies could optimise the healing of cutaneous leishmaniasis lesions achieved after topical application of paromomycin (PM).
Mon Oct 01 00:00:00 UTC 2018
Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection.
Molecular pharmaceutics
Graham-Gurysh E,Moore KM,Satterlee AB,Sheets KT,Lin FC,Bachelder EM,Miller CR,Hingtgen SD,Ainslie KM
14-4801 was used in Immunohistochemistry to show the importance of polymer choice and drug release rate for local drug delivery strategies to improve prognosis for GBM patients.
Mon Mar 05 00:00:00 UTC 2018
Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway.
Cell cycle (Georgetown, Tex.)
Ju S,Ge Y,Li P,Tian X,Wang H,Zheng X,Ju S
14-4801 was used in Immunofluorescence in immunohistochemistry on frozen tissues to demonstrate that dietary quercetin can ameliorate experimental colitis by modulating the anti-inflammatory effects and bactericidal capacity of macrophages via Haem oxygenase-1 dependent pathway.
Thu Sep 05 00:00:00 UTC 2019
Endothelial dysfunction is a superinducer of syndecan-4: fibrogenic role of its ectodomain.
American journal of physiology. Heart and circulatory physiology
Lipphardt M,Song JW,Ratliff BB,Dihazi H,Müller GA,Goligorsky MS
14-4801-82 was used in Immunohistochemistry to show that syndecan-4 is shed to a greater amount because of increased oxidative stress in dysfunctional endothelial cells and that the release of the syndecan-4 ectodomain leads to tubulointerstitial fibrosis.
Thu Mar 01 00:00:00 UTC 2018
Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice.
Endocrinology
Endo-Umeda K,Nakashima H,Umeda N,Seki S,Makishima M
14-4801 was used in Flow cytometry/Cell sorting to study the role fof LXRα in the pathogenesis of steatohepatitis.
Thu Mar 01 00:00:00 UTC 2018
VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury.
Advances in wound care
Wise LM,Stuart GS,Real NC,Fleming SB,Mercer AA
14-4801 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to test the effect of a selective vascular endothelial growth factor receptor-2 activation on scar tissue formation following cutaneous wounding in a murine model.
Wed Aug 01 00:00:00 UTC 2018
Absence of Sirt3 aggravates cisplatin nephrotoxicity via enhanced renal tubular apoptosis and inflammation.
Molecular medicine reports
Kim D,Park W,Lee S,Kim W,Park SK,Kang KP
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate whether Sirtuin3 has anti-inflammatory and anti-apoptotic effects on cisplatin-induced nephrotoxicity.
Mon Oct 01 00:00:00 UTC 2018
Canonical Wnt Signaling Promotes Macrophage Proliferation during Kidney Fibrosis.
Kidney diseases (Basel, Switzerland)
Feng Y,Liang Y,Ren J,Dai C
14-4801 was used in Immunofluorescence in immunohistochemistry on frozen tissues to study the role of canonical Wnt signalling activation on macrophage proliferation during kidney fibrosis.
Fri Jun 01 00:00:00 UTC 2018
JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin.
Nature communications
Singh K,Camera E,Krug L,Basu A,Pandey RK,Munir S,Wlaschek M,Kochanek S,Schorpp-Kistner M,Picardo M,Angel P,Niemann C,Maity P,Scharffetter-Kochanek K
14-4801 was used in Immunohistochemistry-immunofluorescence to define an unprecedented role for JunB in epidermal-pilosebaceous stem cell homeostasis and its pathology.
Fri Aug 24 00:00:00 UTC 2018
Human umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice.
Cell death & disease
Yin Y,Hao H,Cheng Y,Zang L,Liu J,Gao J,Xue J,Xie Z,Zhang Q,Han W,Mu Y
14-4801 was used in Flow cytometry/Cell sorting to provide new clues for searching for the target of β-cell protection.
Mon Jul 09 00:00:00 UTC 2018
WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms.
Journal of neuroinflammation
Wen J,Jones M,Tanaka M,Selvaraj P,Symes AJ,Cox B,Zhang Y
14-4801 was used in Immunofluorescence to examine the therapeutic role of alpha/beta-hydrolase domain 6 inhibition in a rodent model of neuropathic pain.
Mon Jan 08 00:00:00 UTC 2018
Microthrombotic Renal Vascular Lesions Are Associated to Increased Renal Inflammatory Infiltration in Murine Lupus Nephritis.
Frontiers in immunology
Gonzalo-Gil E,García-Herrero C,Toldos O,Usategui A,Criado G,Pérez-Yagüe S,Barber DF,Pablos JL,Galindo M
14-4801 was used in Immunohistochemistry to point to MRL/lpr mice with lupus nephritis as an appropriate model to analyze the potential impact of anti-thrombotic intervention on renal inflammation.
Fri Sep 20 00:00:00 UTC 2019
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice.
Hepatology communications
Morrison MC,Verschuren L,Salic K,Verheij J,Menke A,Wielinga PY,Iruarrizaga-Lejarreta M,Gole L,Yu WM,Turner S,Caspers MPM,Martínez-Arranz I,Pieterman E,Stoop R,van Koppen A,van den Hoek AM,Mato JM,Hanemaaijer R,Alonso C,Kleemann R
14-4801 was used in Immunohistochemistry to show that human molecular signatures can be used to evaluate the translational character of preclinical models for nonalcoholic steatohepatitis.
Sat Dec 01 00:00:00 UTC 2018
The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz.
The Journal of biological chemistry
Feng Y,Liang Y,Zhu X,Wang M,Gui Y,Lu Q,Gu M,Xue X,Sun X,He W,Yang J,Johnson RL,Dai C
14-4801 was used in Immunocytochemistry-Immunofluorescence to investigaye the role of Wnt5a inn regulating M2 macrophage activation that leads to kidney fibrosis.
Fri Dec 14 00:00:00 UTC 2018
Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.
Journal of thrombosis and haemostasis : JTH
Lai JD,Cartier D,Hartholt RB,Swystun LL,van Velzen AS,den Haan JMM,Hough C,Voorberg J,Lillicrap D
14-4801 was used in Immunohistochemistry to assess cellular interactions and expression profiles in hemophilia A mice.
Thu Mar 01 00:00:00 UTC 2018
Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.
Respiratory research
Ni K,Gill A,Tseng V,Mikosz AM,Koike K,Beatman EL,Xu CY,Cao D,Gally F,Mould KJ,Serban KA,Schweitzer KS,March KL,Janssen WJ,Nozik-Grayck E,Garantziotis S,Petrache I
14-4801 was used in Flow cytometry/Cell sorting to show the covalent HC-HA binding, which is exclusively mediated by tumor necrosis factor α (TNFα)-stimulated-gene-6 (TSG-6), may play an important role in the onset or the resolution of lung inflammation in acute lung injury (ALI) induced by respiratory infection.
Thu May 31 00:00:00 UTC 2018
Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation.
Endocrinology
Li Q,Lawrence CR,Nowak RA,Flaws JA,Bagchi MK,Bagchi IC
14-4801-82 was used in Immunohistochemistry to indicate that peritoneal macrophages are vulnerable to BPA or phthalate at levels relevant to human exposure.
Tue May 01 00:00:00 UTC 2018
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
Nature medicine
West NR,Hegazy AN,Owens BMJ,Bullers SJ,Linggi B,Buonocore S,Coccia M,Görtz D,This S,Stockenhuber K,Pott J,Friedrich M,Ryzhakov G,Baribaud F,Brodmerkel C,Cieluch C,Rahman N,Müller-Newen G,Owens RJ,Kühl AA,Maloy KJ,Plevy SE,Keshav S,Travis SPL,Powrie F
14-4801 was used in Immunohistochemistry to study how cytokine oncostatin M is a potential biomarker and therapeutic target for IBD, and has particular relevance for anti-TNF-resistant patients.
Mon May 01 00:00:00 UTC 2017
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.
Cell
Wang Y,Subramanian M,Yurdagul A,Barbosa-Lorenzi VC,Cai B,de Juan-Sanz J,Ryan TA,Nomura M,Maxfield FR,Tabas I
14-4801-82 was used in Immunohistochemistry to show that uptake of multiple ACs by macrophages requires dynamin-related protein 1 (Drp1)-mediated mitochondrial fission, which is triggered by AC uptake.
Thu Oct 05 00:00:00 UTC 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
14-4801 was used in Immunohistochemistry to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 UTC 2017
A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity.
Nature immunology
Chung KJ,Chatzigeorgiou A,Economopoulou M,Garcia-Martin R,Alexaki VI,Mitroulis I,Nati M,Gebler J,Ziemssen T,Goelz SE,Phieler J,Lim JH,Karalis KP,Papayannopoulou T,Blüher M,Hajishengallis G,Chavakis T
14-4801 was used in Flow cytometry/Cell sorting to delineate an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that requires direct adhesive interactions between macrophages and adipocytes.
Thu Jun 01 00:00:00 UTC 2017
A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.
The Journal of clinical investigation
Sindhava VJ,Oropallo MA,Moody K,Naradikian M,Higdon LE,Zhou L,Myles A,Green N,Nündel K,Stohl W,Schmidt AM,Cao W,Dorta-Estremera S,Kambayashi T,Marshak-Rothstein A,Cancro MP
14-4801 was used in Flow cytometry/Cell sorting to describe a relationship among the B cell receptor, TLR9, and cytokine signals that regulate B cell responses to DNA-containing antigens.
Mon May 01 00:00:00 UTC 2017
Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
The Journal of clinical investigation
Koyama Y,Wang P,Liang S,Iwaisako K,Liu X,Xu J,Zhang M,Sun M,Cong M,Karin D,Taura K,Benner C,Heinz S,Bera T,Brenner DA,Kisseleva T
14-4801 was used in Immunohistochemistry to explore the role of mesothelin/mucin 16 signalling in liver fibrosis induced by bile duct ligation.
Mon Apr 03 00:00:00 UTC 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
14-4801 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.
Mon Dec 04 00:00:00 UTC 2017
Serum Iron Protects from Renal Postischemic Injury.
Journal of the American Society of Nephrology : JASN
Vaugier C,Amano MT,Chemouny JM,Dussiot M,Berrou C,Matignon M,Ben Mkaddem S,Wang PHM,Fricot A,Maciel TT,Grapton D,Mathieu JRR,Beaumont C,Peraldi MN,Peyssonnaux C,Mesnard L,Daugas E,Vrtovsnik F,Monteiro RC,Hermine O,Ginzburg YZ,Benhamou M,Camara NOS,Flamant M,Moura IC
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of serum iron in the sterile inflammation that follows kidney ischemia-reperfusion injury.
Fri Dec 01 00:00:00 UTC 2017
Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+ T-cell Recognition of a Retroviral Antigen.
Cancer research
Probst P,Kopp J,Oxenius A,Colombo MP,Ritz D,Fugmann T,Neri D
14-4801 was used in Immunohistochemistry-immunofluorescence to study the use of TNF-linked antibodies to eradicate sarcomas in immunocompetent mice.
Sat Jul 01 00:00:00 UTC 2017
Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection.
Proceedings of the National Academy of Sciences of the United States of America
Nikolaidis NM,Noel JG,Pitstick LB,Gardner JC,Uehara Y,Wu H,Saito A,Lewnard KE,Liu H,White MR,Hartshorn KL,McCormack FX
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of mitogenic stimulation in susceptibility to pneumonia.
Tue Aug 08 00:00:00 UTC 2017
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Cancer immunology research
Kubo H,Mensurado S,Gonçalves-Sousa N,Serre K,Silva-Santos B
14-4801 was used in Flow cytometry/Cell sorting to identifies an innate cell network and the molecular determinants responsible for metastasis immunosurveillance, providing support for using the key molecular mediator to improve immunotherapeutic outcomes.
Fri Sep 01 00:00:00 UTC 2017
Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer.
Cancer immunology research
Cullis J,Siolas D,Avanzi A,Barui S,Maitra A,Bar-Sagi D
14-4801 was used in Immunohistochemistry to reveal an unanticipated role for nab-paclitaxel in macrophage activation and rationalized its potential use to target immune evasion in pancreatic cancer.
Wed Mar 01 00:00:00 UTC 2017
Rictor/mammalian target of rapamycin complex 2 promotes macrophage activation and kidney fibrosis.
The Journal of pathology
Ren J,Li J,Feng Y,Shu B,Gui Y,Wei W,He W,Yang J,Dai C
14-4801 was used in Immunohistochemistry to study the role of Rictor/mTOR complex 2 in regulating macrophage activation and kidney fibrosis.
Tue Aug 01 00:00:00 UTC 2017
Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice.
Frontiers in immunology
Ekmekciu I,von Klitzing E,Fiebiger U,Escher U,Neumann C,Bacher P,Scheffold A,Kühl AA,Bereswill S,Heimesaat MM
Wed Nov 20 00:00:00 UTC 2019
The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent.
Frontiers in immunology
Briet C,Bourdenet G,Rogner UC,Becourt C,Tardivel I,Drouot L,Arnoult C,do Rego JC,Prevot N,Massaad C,Boyer O,Boitard C
14-4801 was used in Immunohistochemistry to characterise the ICOSL-/-NOD model.
Wed Nov 20 00:00:00 UTC 2019
Chronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53.
Oncogene
Swidnicka-Siergiejko AK,Gomez-Chou SB,Cruz-Monserrate Z,Deng D,Liu Y,Huang H,Ji B,Azizian N,Daniluk J,Lu W,Wang H,Maitra A,Logsdon CD
14-4801 was used in Immunohistochemistry to investigate the role of chronic inflammation (CI) in pancreatic cancer and the mechanisms behind CI.
Thu Jun 01 00:00:00 UTC 2017
IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.
PLoS pathogens
Popovic B,Golemac M,Podlech J,Zeleznjak J,Bilic-Zulle L,Lukic ML,Cicin-Sain L,Reddehase MJ,Sparwasser T,Krmpotic A,Jonjic S
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to study the importance of IL-33 in the suppressive function of liver regulatory T cells during cytomegalovirus infection.
Sat Apr 01 00:00:00 UTC 2017
Mycobacterium tuberculosis infection modulates adipose tissue biology.
PLoS pathogens
Beigier-Bompadre M,Montagna GN,Kühl AA,Lozza L,Weiner J,Kupz A,Vogelzang A,Mollenkopf HJ,Löwe D,Bandermann S,Dorhoi A,Brinkmann V,Matuschewski K,Kaufmann SHE
14-4801 was used in Immunohistochemistry to conclude that adipose tissue is a potential niche for Mtb and that due to infection CD8+ T cells and NK cells are attracted to this tissue.
Sun Oct 01 00:00:00 UTC 2017
Macrophages are required to coordinate mouse digit tip regeneration.
Development (Cambridge, England)
Simkin J,Sammarco MC,Marrero L,Dawson LA,Yan M,Tucker C,Cammack A,Muneoka K
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to examine the role of macrophages in coordinating the epimorphic regenerative response in mammals.
Wed Nov 01 00:00:00 UTC 2017
Galectin-3-null mice display defective neutrophil clearance during acute inflammation.
Journal of leukocyte biology
Wright RD,Souza PR,Flak MB,Thedchanamoorthy P,Norling LV,Cooper D
14-4801 was used in Flow cytometry/Cell sorting to show murine Galectin-3 mediates neutrophil clearance during acute inflammation.
Wed Mar 01 00:00:00 UTC 2017
Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis.
Journal of molecular medicine (Berlin, Germany)
Svinka J,Pflügler S,Mair M,Marschall HU,Hengstler JG,Stiedl P,Poli V,Casanova E,Timelthaler G,Sibilia M,Eferl R
14-4801 was used in Immunohistochemistry to demonstrate hepatoprotective functions of the STAT3-EGFR signaling axis in cholestatic liver disease.
Sun Jan 01 00:00:00 UTC 2017
Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Lou H,Lu J,Choi EB,Oh MH,Jeong M,Barmettler S,Zhu Z,Zheng T
14-4801 was used in Immunohistochemistry to indicate that IL-22 plays important pathogenic roles in the initiation and development of Alzheimer's disease.
Sat Apr 01 00:00:00 UTC 2017
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice.
BMB reports
Kim OH,Kim H,Kang J,Yang D,Kang YH,Lee DH,Cheon GJ,Park SC,Oh BC
14-4801 was used in Western Blotting to identify age-dependent macrophage accumulation in the bone marrow, showing that ageing significantly increases the number of M1 macrophages and impairs polarisation of BMDMs.
Sun Jan 01 00:00:00 UTC 2017
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice.
BMB reports
Kim OH,Kim H,Kang J,Yang D,Kang YH,Lee DH,Cheon GJ,Park SC,Oh BC
14-4801 was used in Western Blotting to identify age-dependent macrophage accumulation in the bone marrow, showing that ageing significantly increases the number of M1 macrophages and impairs polarisation of BMDMs.
Sun Jan 01 00:00:00 UTC 2017
Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice.
The Journal of endocrinology
Wolf Greenstein A,Majumdar N,Yang P,Subbaiah PV,Kineman RD,Cordoba-Chacon J
14-4801 was used in Immunohistochemistry to examine the hepatocyte-specific, peroxisome proliferator-activated receptor γ(PPARγ)-regulated mechanisms in mice responsible for promoting steatosis.
Sun Jan 01 00:00:00 UTC 2017
Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis.
Mediators of inflammation
Carrière V,Arshad MI,Le Seyec J,Lefevre B,Farooq M,Jan A,Manuel C,Touami-Bernard L,Lucas-Clerc C,Genet V,Gascan H,Girard JP,Chalmel F,Lamontagne L,Piquet-Pellorce C,Samson M
14-4801 was used in Immunohistochemistry to demonstrate that endogenous IL-33 has multifaceted immunoregulatory effect during viral hepatitis.
Tue Mar 27 00:00:00 UTC 2018
Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation.
Cell transplantation
Chow KV,Carrington EM,Zhan Y,Lew AM,Sutherland RM
14-4801 was used in Flow cytometry/Cell sorting to transplant MHC-mismatched BALB/c (H-2d) islets into diabetic C57BL/6-CCR2.DTR recipients (H-2b) treated with either saline (control) or diphtheria toxin (DT) to deplete moDCs.
Thu Feb 16 00:00:00 UTC 2017
Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer.
Oncoimmunology
Kumar S,Davra V,Obr AE,Geng K,Wood TL,De Lorenzo MS,Birge RB
14-4801 was used in Immunohistochemistry to demonstrate that genetic ablation of Crk by CRISPR-Cas9 leads to enhanced anti-tumour immune cell populations, cytotoxic effector and immune surveillance cytokines in a triple-negative breast cancer model.
Tue Jan 12 00:00:00 UTC 2021
CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice.
Hepatology communications
Zimmer M,Bista P,Benson EL,Lee DY,Liu F,Picarella D,Vega RB,Vu CB,Yeager M,Ding M,Liang G,Horton JD,Kleemann R,Kooistra T,Morrison MC,Wielinga PY,Milne JC,Jirousek MR,Nichols AJ
14-4801 was used in Immunohistochemistry to study the use of sterol regulatory element-binding protein inhibition as a promising new strategy for the prevention and treatment of diseases associated with abnormal lipid metabolism.
Thu Jun 01 00:00:00 UTC 2017
Lesion development is modulated by the natural estrous cycle and mouse strain in a minimally invasive model of endometriosis.
Biology of reproduction
Dodds KN,Beckett EAH,Evans SF,Hutchinson MR
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to show that our minimally invasive model would be beneficial for studies with outcome measurements particularly sensitive to incisional injury, such as pain, or alterations to sex hormones, including fertility.
Sun Jan 01 00:00:00 UTC 2017
Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation.
Molecular cancer
Tang X,Wang X,Zhao YY,Curtis JM,Brindley DN
14-4801 was used in Immunohistochemistry to determine the impact of doxycycline on circulating lysophosphatidate concentrations and tumor growth using a syngeneic orthotopic mouse model of breast cancer.
Wed Feb 08 00:00:00 UTC 2017
Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression.
Scientific reports
Zeng Z,Yang H,Wang Y,Ren J,Dai Y,Dai C
14-4801 was used in Immunofluorescence to determine that n-3 PUFAs have protective roles in kidney fibrosis by suppressing TGFβ1-induced fibroblast activation.
Mon Apr 10 00:00:00 UTC 2017
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.
Nature communications
Zhang H,Fillmore Brainson C,Koyama S,Redig AJ,Chen T,Li S,Gupta M,Garcia-de-Alba C,Paschini M,Herter-Sprie GS,Lu G,Zhang X,Marsh BP,Tuminello SJ,Xu C,Chen Z,Wang X,Akbay EA,Zheng M,Palakurthi S,Sholl LM,Rustgi AK,Kwiatkowski DJ,Diehl JA,Bass AJ,Sharpless NE,Dranoff G,Hammerman PS,Ji H,Bardeesy N,Saur D,Watanabe H,Kim CF,Wong KK
14-4801 was used in Immunohistochemistry to demonstrate that bronchioalveolar stem cells and club cells are the likely origin for squamous cell carcinoma transitioned tumours.
Fri Apr 07 00:00:00 UTC 2017
Evidence for biochemical barrier restoration: Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis.
Scientific reports
Arbiser JL,Nowak R,Michaels K,Skabytska Y,Biedermann T,Lewis MJ,Bonner MY,Rao S,Gilbert LC,Yusuf N,Karlsson I,Fritz Y,Ward NL
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to assess solenopsin analogs in vivo bioactivity in a well-established mouse model of psoriasis, the KC-Tie2 mouse.
Mon Sep 11 00:00:00 UTC 2017
Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion.
JCI insight
Liu J,Kumar S,Dolzhenko E,Alvarado GF,Guo J,Lu C,Chen Y,Li M,Dessing MC,Parvez RK,Cippà PE,Krautzberger AM,Saribekyan G,Smith AD,McMahon AP
14-4801 was used in Immunofluorescence in immunohistochemistry on frozen tissues to provide a comprehensive profile of injury, repair, and long-term maladaptive responses following ischaemia/reperfusion injury.
Thu Sep 21 00:00:00 UTC 2017
Functional characterization of the lysosomal membrane protein TMEM192 in mice.
Oncotarget
Nguyen TL,Schneppenheim J,Rudnik S,Lüllmann-Rauch R,Bernreuther C,Hermans-Borgmeyer I,Glatzel M,Saftig P,Schröder B
14-4801-82 was used in Flow Cytometry to conclude that under basal conditions in vivo the loss of TMEM192 can be efficiently compensated by alternative pathways.
Tue Jul 04 00:00:00 UTC 2017
Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus.
Nature communications
Llorente C,Jepsen P,Inamine T,Wang L,Bluemel S,Wang HJ,Loomba R,Bajaj JS,Schubert ML,Sikaroodi M,Gillevet PM,Xu J,Kisseleva T,Ho SB,DePew J,Du X,Sørensen HT,Vilstrup H,Nelson KE,Brenner DA,Fouts DE,Schnabl B
Mon Oct 16 00:00:00 UTC 2017
HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival.
Cell death & disease
Lacher SM,Bruttger J,Kalt B,Berthelet J,Rajalingam K,Wörtge S,Waisman A
14-4801 was used in Flow cytometry/Cell sorting to show that protein prenylation rather than cholesterol biosynthesis pathway is indispensible for T-cell survival.
Thu May 25 00:00:00 UTC 2017
One Year Follow-Up Risk Assessment in SKH-1 Mice and Wounds Treated with an Argon Plasma Jet.
International journal of molecular sciences
Schmidt A,Woedtke TV,Stenzel J,Lindner T,Polei S,Vollmar B,Bekeschus S
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to investigate the longterm side effects of repetitive plasma treatment in a rodent full-thickness ear wound model.
Wed Apr 19 00:00:00 UTC 2017
Complement inhibition attenuates acute kidney injury after ischemia-reperfusion and limits progression to renal fibrosis in mice.
PloS one
Danobeitia JS,Ziemelis M,Ma X,Zitur LJ,Zens T,Chlebeck PJ,Van Amersfoort ES,Fernandez LA
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate the impact of human C1-inhibitor on the early inflammatory response to ischaemia-reperfusion injury and the subsequent progression to fibrosis in mice.
Tue Nov 07 00:00:00 UTC 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-4801 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 UTC 2017
Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy.
Nature communications
Zhu G,Mei L,Vishwasrao HD,Jacobson O,Wang Z,Liu Y,Yung BC,Fu X,Jin A,Niu G,Wang Q,Zhang F,Shroff H,Chen X
14-4801 was used in Flow cytometry/Cell sorting to evaluate the use of intertwining DNA-RNA nanocapsules as vaccines for cancer immunotherapy.
Tue Nov 14 00:00:00 UTC 2017
MicroRNA-449a deficiency promotes colon carcinogenesis.
Scientific reports
Niki M,Nakajima K,Ishikawa D,Nishida J,Ishifune C,Tsukumo SI,Shimada M,Nagahiro S,Mitamura Y,Yasutomo K
14-4801 was used in Flow cytometry/Cell sorting to suggest that miR-449a acted as a key regulator of colon tumorigenesis by controlling the proliferation of intestinal epithelial cells.
Wed Sep 06 00:00:00 UTC 2017
The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.
Hepatology communications
Xu J,Ma HY,Liang S,Sun M,Karin G,Koyama Y,Hu R,Quehenberger O,Davidson NO,Dennis EA,Kisseleva T,Brenner DA
14-4801-82 was used in Immunohistochemistry to analyze mice expressing only the human CYP2E1 gene to determine differences in hCYP2E1 versus endogenous mouse Cyp2e1 function with different liver injuries.
Fri Dec 01 00:00:00 UTC 2017
Erythropoietin enhances Kupffer cell number and activity in the challenged liver.
Scientific reports
Gilboa D,Haim-Ohana Y,Deshet-Unger N,Ben-Califa N,Hiram-Bab S,Reuveni D,Zigmond E,Gassmann M,Gabet Y,Varol C,Neumann D
Mon Sep 04 00:00:00 UTC 2017
Multidrug-Resistant Pseudomonas Aeruginosa Induce Systemic Pro-Inflammatory Immune Responses in Colonized Mice.
European journal of microbiology & immunology
von Klitzing E,Bereswill S,Heimesaat MM
Fri Sep 01 00:00:00 UTC 2017
EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination.
Journal of neuroinflammation
Rutkowska A,Sailer AW,Dev KK
Sat Dec 16 00:00:00 UTC 2017
Lactobacillus johnsonii ameliorates intestinal, extra-intestinal and systemic pro-inflammatory immune responses following murine Campylobacter jejuni infection.
Scientific reports
Bereswill S,Ekmekciu I,Escher U,Fiebiger U,Stingl K,Heimesaat MM
Thu May 18 00:00:00 UTC 2017
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Nature medicine
Mole DJ,Webster SP,Uings I,Zheng X,Binnie M,Wilson K,Hutchinson JP,Mirguet O,Walker A,Beaufils B,Ancellin N,Trottet L,Bénéton V,Mowat CG,Wilkinson M,Rowland P,Haslam C,McBride A,Homer NZ,Baily JE,Sharp MG,Garden OJ,Hughes J,Howie SE,Holmes DS,Liddle J,Iredale JP
14480182 was used in immunohistochemistry - paraffin section to demonstrate a critical role for kynurenine-3-monooxygenase in the pathogenesis of acute pancreatitis
Mon Feb 01 00:00:00 UTC 2016
MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue.
Circulation research
Sun X,Lin J,Zhang Y,Kang S,Belkin N,Wara AK,Icli B,Hamburg NM,Li D,Feinberg MW
14-4801 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to assess whether microRNA-181b impacts the pathogenesis of insulin resistance by regulating endothelial cell function in adipose tissue during obesity.
Fri Mar 04 00:00:00 UTC 2016
MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue.
Circulation research
Sun X,Lin J,Zhang Y,Kang S,Belkin N,Wara AK,Icli B,Hamburg NM,Li D,Feinberg MW
14-4801 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to assess whether microRNA-181b impacts the pathogenesis of insulin resistance by regulating endothelial cell function in adipose tissue during obesity.
Fri Mar 04 00:00:00 UTC 2016
MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue.
Circulation research
Sun X,Lin J,Zhang Y,Kang S,Belkin N,Wara AK,Icli B,Hamburg NM,Li D,Feinberg MW
14-4801 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to assess whether microRNA-181b impacts the pathogenesis of insulin resistance by regulating endothelial cell function in adipose tissue during obesity.
Fri Mar 04 00:00:00 UTC 2016
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.
Circulation research
Cameron AR,Morrison VL,Levin D,Mohan M,Forteath C,Beall C,McNeilly AD,Balfour DJ,Savinko T,Wong AK,Viollet B,Sakamoto K,Fagerholm SC,Foretz M,Lang CC,Rena G
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that anti-inflammatory properties of metformin are exerted irrespective of diabetes mellitus status.
Fri Aug 19 00:00:00 UTC 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
14-4801 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.
Fri Apr 01 00:00:00 UTC 2016
Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12.
The Journal of experimental medicine
Everts B,Tussiwand R,Dreesen L,Fairfax KC,Huang SC,Smith AM,O'Neill CM,Lam WY,Edelson BT,Urban JF,Murphy KM,Pearce EJ
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of CD8α+ and CD103+ dendritic cells in suppressing helminth-driven type 2 immune responses.
Mon Jan 11 00:00:00 UTC 2016
Carbonic anhydrase enzymes regulate mast cell-mediated inflammation.
The Journal of experimental medicine
Henry EK,Sy CB,Inclan-Rico JM,Espinosa V,Ghanny SS,Dwyer DF,Soteropoulos P,Rivera A,Siracusa MC
14480182 was used in flow cytometry to find a role for Car enzymes in regulating mast cell lineage commitment
Mon Aug 22 00:00:00 UTC 2016
Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.
Proceedings of the National Academy of Sciences of the United States of America
Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK
14-4801 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.
Tue Feb 09 00:00:00 UTC 2016
In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kirschbaum K,Sonner JK,Zeller MW,Deumelandt K,Bode J,Sharma R,Krüwel T,Fischer M,Hoffmann A,Costa da Silva M,Muckenthaler MU,Wick W,Tews B,Chen JW,Heiland S,Bendszus M,Platten M,Breckwoldt MO
14-4801-82 was used in Immunohistochemistry to show that noninvasive molecular imaging of innate immune responses can serve as an imaging biomarker of disease activity in autoimmune-mediated neuroinflammation with potential clinical applications in a wide range of inflammatory diseases.
Tue Nov 15 00:00:00 UTC 2016
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Arteriosclerosis, thrombosis, and vascular biology
Harmon DB,Srikakulapu P,Kaplan JL,Oldham SN,McSkimming C,Garmey JC,Perry HM,Kirby JL,Prohaska TA,Gonen A,Hallowell P,Schirmer B,Tsimikas S,Taylor AM,Witztum JL,McNamara CA
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of B-cell functions in obesity-induced metabolic dysfunction.
Fri Apr 01 00:00:00 UTC 2016
The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria.
Science signaling
Billings EA,Lee CS,Owen KA,D'Souza RS,Ravichandran KS,Casanova JE
14-4801 was used in Flow cytometry/Cell sorting to demonstrate the role of GPCR BAI1 in the clearance of gram-negative bacteria by stimulation of phagocytosis and initiation of reactive oxygen species production in macrophages.
Tue Feb 02 00:00:00 UTC 2016
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mucosal immunology
Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM
14-4801 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.
Fri Jan 01 00:00:00 UTC 2016
CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.
Mucosal immunology
Arnold IC,Mathisen S,Schulthess J,Danne C,Hegazy AN,Powrie F
14-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism by which IL-23 produced by CD11c+ monocytes/macrophages promotes chronic Helicobacter hepaticus-induced intestinal inflammation.
Tue Mar 01 00:00:00 UTC 2016
Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models.
Molecular cancer therapeutics
Park SY,Piao Y,Jeong KJ,Dong J,de Groot JF
14-4801 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to suggest that periostin plays an important role in glioma invasion and resistance to antiangiogenic therapy.
Thu Sep 01 00:00:00 UTC 2016
Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pitts MG,Myers-Morales T,D'Orazio SE
14-4801 was used in Flow cytometry/Cell sorting to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.
Fri Apr 01 00:00:00 UTC 2016
The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection.
Gut pathogens
Heimesaat MM,Grundmann U,Alutis ME,Fischer A,Göbel UB,Bereswill S
14-4801 was used in Immunohistochemistry to elucidate the molecular mechanisms which drive campylobacteriosis in mice lacking IL-23p19, IL-22, and IL-18.
Thu Jul 07 00:00:00 UTC 2016
The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury.
Endocrinology
Song L,Papaioannou G,Zhao H,Luderer HF,Miller C,Dall'Osso C,Nazarian RM,Wagers AJ,Demay MB
14-4801 was used in Immunohistochemistry to characterize the activation state of macrophages in the wounds of vitamin D receptor null mice.
Sat Oct 01 00:00:00 UTC 2016
mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.
Carcinogenesis
Callejas-Valera JL,Iglesias-Bartolome R,Amornphimoltham P,Palacios-Garcia J,Martin D,Califano JA,Molinolo AA,Gutkind JS
14-4801 was used in Immunohistochemistry to determine how interactions between HPV-oncogenes and carcinogenic exposure results in squamous cell carcinoma.
Sat Oct 01 00:00:00 UTC 2016
Temporal and spatial distribution of macrophage phenotype markers in the foreign body response to glutaraldehyde-crosslinked gelatin hydrogels.
Journal of biomaterials science. Polymer edition
Yu T,Wang W,Nassiri S,Kwan T,Dang C,Liu W,Spiller KL
14-4801 was used in Immunohistochemistry to show that macrophages in the foreign body response exhibit characteristics of both M1 and M2 phenotypes.
Thu Dec 29 00:00:00 UTC 2016
Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice.
Infection and immunity
Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM
14-4801 was used in Immunohistochemistry to investigate T. cruzi infection as a trigger of vasculitis.
Fri Apr 01 00:00:00 UTC 2016
Inactivation of Peroxiredoxin 6 by the Pla Protease of Yersinia pestis.
Infection and immunity
Zimbler DL,Eddy JL,Schroeder JA,Lathem WW
14-4801 was used in Flow cytometry/Cell sorting to describe a proteomic screen which helps to identify host proteins that are cleaved or processed by Yersinia pestis.
Fri Jan 01 00:00:00 UTC 2016
Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection.
Infection and immunity
Chen G,Wang SH,Jang JC,Odegaard JI,Nair MG
14-4801 was used in Flow cytometry/Cell sorting to delineate the function of two resistin-like molecules, RELMα and RELMβ, following infection with hookworm.
Fri Apr 01 00:00:00 UTC 2016
Endothelial sirtuin 1 inactivation enhances capillary rarefaction and fibrosis following kidney injury through Notch activation.
Biochemical and biophysical research communications
Kida Y,Zullo JA,Goligorsky MS
14-4801 was used in Immunohistochemistry on frozen tissues to study the molecular mechanisms of peritubular capillary loss.
Fri Sep 23 00:00:00 UTC 2016
Global miRNA expression is temporally correlated with acute kidney injury in mice.
PeerJ
Cui R,Xu J,Chen X,Zhu W
14-4801 was used in Immunohistochemistry to investigate whether miRNAs are inductive regulators responsible for the pathological development of acute kidney injury.
Fri Mar 11 00:00:00 UTC 2016
PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.
Cell death & disease
Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J
14-4801 was used in Immunohistochemistry to reveal that Per1 interaction with PPAR-γ prevents an excessive innate immune response in endotoxin-induced liver injury.
Thu Apr 07 00:00:00 UTC 2016
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.
Scientific reports
Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B
14-4801 was used in Immunohistochemistry to show, for the first time, that miR-150 regulates obesity-induced metainflammation and insulin resistance by controlling adipose tissue B cell function.
Mon Feb 01 00:00:00 UTC 2016
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.
Nature communications
Yip KH,Kolesnikoff N,Hauschild N,Biggs L,Lopez AF,Galli SJ,Kumar S,Grimbaldeston MA
14-4801 was used in Flow cytometry/Cell sorting to reveal that Nedd4-2 and Ndfip1 have an important function in negatively regulating IgE-dependent mast cell activity in IgE-dependent allergic disorders.
Thu Oct 27 00:00:00 UTC 2016
Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.
Scientific reports
Cousins FL,Kirkwood PM,Saunders PT,Gibson DA
14480182 was used in immunohistochemistry to use a mouse model of menstruation to examine changes in mononuclear phagocytes during endometrial repair and remodeling
Wed Nov 09 00:00:00 UTC 2016
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.
Nature communications
Le CP,Nowell CJ,Kim-Fuchs C,Botteri E,Hiller JG,Ismail H,Pimentel MA,Chai MG,Karnezis T,Rotmensz N,Renne G,Gandini S,Pouton CW,Ferrari D,Möller A,Stacker SA,Sloan EK
14-4801 was used in Immunohistochemistry to suggest that limiting the effects of SNS signalling to prevent tumour cell dissemination through lymphatic routes may provide a strategy to improve cancer outcomes.
Tue Mar 01 00:00:00 UTC 2016
NADPH Oxidases Are Essential for Macrophage Differentiation.
The Journal of biological chemistry
Xu Q,Choksi S,Qu J,Jang J,Choe M,Banfi B,Engelhardt JF,Liu ZG
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of NOX1 and NOX2 in macrophage differentiation and tumor progression.
Fri Sep 16 00:00:00 UTC 2016
Brain trauma elicits non-canonical macrophage activation states.
Journal of neuroinflammation
Kim CC,Nakamura MC,Hsieh CL
14-4801 was used in Flow cytometry/Cell sorting to investigate the novel activation states involved in the early macrophage response to traumatic brain injury.
Tue May 24 00:00:00 UTC 2016
Orally administered β-glucan attenuates the Th2 response in a model of airway hypersensitivity.
SpringerPlus
Burg AR,Quigley L,Jones AV,O'Connor GM,Boelte K,McVicar DW,Orr SJ
14-4801 was used in Flow cytometry/Cell sorting to study the immunological effects of WGP containing β-1,3/1,6-glucans in a mouse model of asthma and consider its therapeutic potential.
Fri Jul 08 00:00:00 UTC 2016
Interleukin 6 regulates psoriasiform inflammation-associated thrombosis.
JCI insight
Wang Y,Golden JB,Fritz Y,Zhang X,Diaconu D,Camhi MI,Gao H,Dawes SM,Xing X,Ganesh SK,Gudjonsson JE,Simon DI,McCormick TS,Ward NL
14-4801 was used in Immunohistochemistry on frozen tissues to investigate the role of MRP8/14 in increased heart attack risk in psoriasis patients, showing that interleukin 6 regulates psoriasiform inflammation-associated thrombosis.
Thu Dec 08 00:00:00 UTC 2016
Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction.
Scientific reports
Li J,Gui Y,Ren J,Liu X,Feng Y,Zeng Z,He W,Yang J,Dai C
14-4801 was used in Immunofluorescence to demonstrate that metformin may protect against cisplatin-induced tubular cell apoptosis and acute kidney injury through stimulating AMPKα activation and autophagy induction.
Thu Apr 07 00:00:00 UTC 2016
Overexpression of Heme Oxygenase-1 Prevents Renal Interstitial Inflammation and Fibrosis Induced by Unilateral Ureter Obstruction.
PloS one
Chen X,Wei SY,Li JS,Zhang QF,Wang YX,Zhao SL,Yu J,Wang C,Qin Y,Wei QJ,Lv GX,Li B
14-4801 was used in Immunohistochemistry to suggest that heme oxygenase-1 may prevent renal tubulointerstitial fibrosis by regulating the inflammatory response and Wnt/β-catenin signaling.
Fri Jul 08 00:00:00 UTC 2016
The Role of IL-23, IL-22, and IL-18 in Campylobacter Jejuni Infection of Conventional Infant Mice.
European journal of microbiology & immunology
Heimesaat MM,Alutis ME,Grundmann U,Fischer A,Göbel UB,Bereswill S
14-4801 was used in Immunohistochemistry to elucidate the varying immunopathological effects of three cytokines alongside Campylobacter jejuni infection.
Fri Jun 24 00:00:00 UTC 2016
Systemic depletion of macrophages in the subacute phase of wound healing reduces hypertrophic scar formation.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Zhu Z,Ding J,Ma Z,Iwashina T,Tredget EE
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to suggest that systemic macrophage depletion in subacute phase of wound healing reduces scar formation, which provides evidence for the pro-fibrotic role of macrophages in fibrosis of human skin as well as insight into the potential benefits of specifically depleting M2 macrophages in vivo.
Fri Jul 01 00:00:00 UTC 2016
IL-6 Signaling in Myelomonocytic Cells Is Not Crucial for the Development of IMQ-Induced Psoriasis.
PloS one
Klebow S,Hahn M,Nikoalev A,Wunderlich FT,Hövelmeyer N,Karbach SH,Waisman A
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of IL-6 signalling in myelomonocytic cells during experimental psoriasis.
Sun Jul 31 00:00:00 UTC 2016
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Nature medicine
Alam MS,Gaida MM,Bergmann F,Lasitschka F,Giese T,Giese NA,Hackert T,Hinz U,Hussain SP,Kozlov SV,Ashwell JD
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that TCR-mediated activation of CD4+ TIL results in alternative p38 activation and production of pro-tumorigenic factors.
Sun Nov 01 00:00:00 UTC 2015
Neutrophil ageing is regulated by the microbiome.
Nature
Zhang D,Chen G,Manwani D,Mortha A,Xu C,Faith JJ,Burk RD,Kunisaki Y,Jang JE,Scheiermann C,Merad M,Frenette PS
14-4801 was used in Flow cytometry/Cell sorting to show that neutrophil pro-inflammatory activity correlates positively with their ageing whilst in circulation.
Thu Sep 24 00:00:00 UTC 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
14-4801-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.
Tue Dec 15 00:00:00 UTC 2015
Class-switched memory B cells remodel BCRs within secondary germinal centers.
Nature immunology
McHeyzer-Williams LJ,Milpied PJ,Okitsu SL,McHeyzer-Williams MG
14-4801 was used in Magnetic cell separation to demonstrate that vaccine boosts re-activate a cyclic germinal centre transcriptional program in class-switched memory B cells to remodel existing antibody specificities and enhance durable immunological protection.
Sun Mar 01 00:00:00 UTC 2015
Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease.
The Journal of clinical investigation
Chen L,Zhou X,Fan LX,Yao Y,Swenson-Fields KI,Gadjeva M,Wallace DP,Peters DJ,Yu A,Grantham JJ,Li X
14-4801 was used in Immunofluorescence to investigate the functional roles and mechanisms of macrophage inhibitory factor in polycystic kidney disease.
Mon Jun 01 00:00:00 UTC 2015
Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis.
Kidney international
Li J,Ren J,Liu X,Jiang L,He W,Yuan W,Yang J,Dai C
14-4801 was used in Immunofluorescence to assess the contribution of Rictor/mTORC2 signalling to the development of chronic kidney diseases.
Tue Sep 01 00:00:00 UTC 2015
Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells.
The Journal of experimental medicine
Ortiz ML,Kumar V,Martner A,Mony S,Donthireddy L,Condamine T,Seykora J,Knight SC,Malietzis G,Lee GH,Moorghen M,Lenox B,Luetteke N,Celis E,Gabrilovich D
14-4801 was used in Immunohistochemistry on frozen tissues to investigate the cellular mechanisms linking chronic inflammation with cancer, showing that immature myeloid cells contribute to skin tumour development by recruiting IL-17-producing CD4+ T cells.
Mon Mar 09 00:00:00 UTC 2015
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.
The Journal of experimental medicine
Dutta P,Hoyer FF,Grigoryeva LS,Sager HB,Leuschner F,Courties G,Borodovsky A,Novobrantseva T,Ruda VM,Fitzgerald K,Iwamoto Y,Wojtkiewicz G,Sun Y,Da Silva N,Libby P,Anderson DG,Swirski FK,Weissleder R,Nahrendorf M
14-4801 was used in Immunofluorescence to show that red pulp vascular cell adhesion molecule 1 macrophages are essential to extramedullary myelopoiesis.
Mon Apr 06 00:00:00 UTC 2015
TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.
The Journal of experimental medicine
Wu K,Byers DE,Jin X,Agapov E,Alexander-Brett J,Patel AC,Cella M,Gilfilan S,Colonna M,Kober DL,Brett TJ,Holtzman MJ
14-4801 was used in Flow cytometry/Cell sorting to define the link between viral infection and type 2 immune response in chronic respiratory disease, showing that expression of TREM2 in macrophages is required, particularly soluble TREM2, which prevents apoptosis of macrophages and leads to chronic inflammatory disease.
Mon May 04 00:00:00 UTC 2015
Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors.
Arthritis & rheumatology (Hoboken, N.J.)
Marangoni RG,Korman BD,Wei J,Wood TA,Graham LV,Whitfield ML,Scherer PE,Tourtellotte WG,Varga J
14-4801 was used in Immunohistochemistry to establish a novel link between intradermal adipose tissue loss and dermal fibrosis.
Wed Apr 01 00:00:00 UTC 2015
Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling.
Journal of the American Society of Nephrology : JASN
Zhou L,Li Y,Hao S,Zhou D,Tan RJ,Nie J,Hou FF,Kahn M,Liu Y
14-4801 was used in Immunohistochemistry to indicate that blockade of Wnt/β-catenin signaling can repress multiple RAS genes, leading to reversal of established proteinuria and kidney injury.
Thu Jan 01 00:00:00 UTC 2015
IL-25 Elicits Innate Lymphoid Cells and Multipotent Progenitor Type 2 Cells That Reduce Renal Ischemic/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Huang Q,Niu Z,Tan J,Yang J,Liu Y,Ma H,Lee VW,Sun S,Song X,Guo M,Wang Y,Cao Q
14-4801 was used in Flow cytometry/Cell sorting to identify a mechanism whereby IL-25-elicited ILC2 and MPP(type2) cells regulate macrophage phenotype in kidney and prevent renal IRI.
Tue Sep 01 00:00:00 UTC 2015
IL-25 Elicits Innate Lymphoid Cells and Multipotent Progenitor Type 2 Cells That Reduce Renal Ischemic/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Huang Q,Niu Z,Tan J,Yang J,Liu Y,Ma H,Lee VW,Sun S,Song X,Guo M,Wang Y,Cao Q
14-4801 was used in Flow cytometry/Cell sorting to identify a mechanism whereby IL-25-elicited ILC2 and MPP(type2) cells regulate macrophage phenotype in kidney and prevent renal IRI.
Tue Sep 01 00:00:00 UTC 2015
SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells.
Cancer immunology research
Yu H,Liu Y,McFarland BC,Deshane JS,Hurst DR,Ponnazhagan S,Benveniste EN,Qin H
14-4801 was used in Flow cytometry/Cell sorting to assess the effect of genetic deletion of SOCS3 in myeloid cells on tumour growth.
Wed Jul 01 00:00:00 UTC 2015
Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.
Arteriosclerosis, thrombosis, and vascular biology
Ruan CC,Ge Q,Li Y,Li XD,Chen DR,Ji KD,Wu YJ,Sheng LJ,Yan C,Zhu DL,Gao PJ
14-4801 was used in Immunofluorescence to demonstrate that bone marrow-derived macrophages in PVAT are crucial for complement activation in hypertensive vascular inflammation.
Sun Mar 01 00:00:00 UTC 2015
Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development.
Stroke
Lee S,Chu HX,Kim HA,Real NC,Sharif S,Fleming SB,Mercer AA,Wise LM,Drummond GR,Sobey CG
14-4801 was used in Flow cytometry/Cell sorting to investigate whether post-stroke administration of a chemokine-binding protein, derived from the parapoxvirus bovine papular stomatitis virus, might reduce infiltration of leukocytes into the brain and therefore limit infarct development.
Sun Feb 01 00:00:00 UTC 2015
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
PLoS biology
Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ
14-4801 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.
Tue Dec 01 00:00:00 UTC 2015
The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages.
eLife
Park C,Arthos J,Cicala C,Kehrl JH
14-4801 was used in Flow cytometry/Cell sorting to reveal a specialised lymph node antigen delivery system capable of delivering gp120 and other pathogen-derived glycoproteins to B cells.
Mon Aug 10 00:00:00 UTC 2015
Immune surveillance of the lung by migrating tissue monocytes.
eLife
Rodero MP,Poupel L,Loyher PL,Hamon P,Licata F,Pessel C,Hume DA,Combadière C,Boissonnas A
14-4801 was used in Flow cytometry/Cell sorting to compare the contribution of monocytes to innate immune surveillance of the lung in the steady state with macrophage and dendritic cells.
Mon Jul 13 00:00:00 UTC 2015
Foxm1 regulates resolution of hyperoxic lung injury in newborns.
American journal of respiratory cell and molecular biology
Xia H,Ren X,Bolte CS,Ustiyan V,Zhang Y,Shah TA,Kalin TV,Whitsett JA,Kalinichenko VV
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that Foxm1 influences pulmonary inflammatory responses to hyperoxia, inhibiting neutrophil-derived enzymes and enhancing monocytic responses that limit alveolar injury and remodeling in neonatal lungs.
Fri May 01 00:00:00 UTC 2015
MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages.
The Journal of investigative dermatology
Rohani MG,McMahan RS,Razumova MV,Hertz AL,Cieslewicz M,Pun SH,Regnier M,Wang Y,Birkland TP,Parks WC
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to demonstrate a critical role for macrophage MMP-10 in controlling the tissue remodeling activity of macrophages and moderating scar formation during wound repair.
Thu Oct 01 00:00:00 UTC 2015
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
PLoS pathogens
Napier RJ,Norris BA,Swimm A,Giver CR,Harris WA,Laval J,Napier BA,Patel G,Crump R,Peng Z,Bornmann W,Pulendran B,Buller RM,Weiss DS,Tirouvanziam R,Waller EK,Kalman D
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that potentiation of the immune response by imatinib may facilitate clearance of diverse microbial pathogens.
Sun Mar 01 00:00:00 UTC 2015
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
PLoS pathogens
Napier RJ,Norris BA,Swimm A,Giver CR,Harris WA,Laval J,Napier BA,Patel G,Crump R,Peng Z,Bornmann W,Pulendran B,Buller RM,Weiss DS,Tirouvanziam R,Waller EK,Kalman D
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that potentiation of the immune response by imatinib may facilitate clearance of diverse microbial pathogens.
Sun Mar 01 00:00:00 UTC 2015
The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection.
PLoS pathogens
Dalton JE,Glover AC,Hoodless L,Lim EK,Beattie L,Kirby A,Kaye PM
14-4801 was used in Flow cytometry/Cell sorting to investigate how Ntrk2 plays a role in the pathologic remodeling of the spleen that accompanies chronic infection.
Sun Feb 01 00:00:00 UTC 2015
γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice.
Journal of leukocyte biology
Mehta P,Nuotio-Antar AM,Smith CW
14-4801 was used in Flow cytometry/Cell sorting to reveal that isolated γδ T cells directly stimulated RAW264.7 macrophage TNF-α expression but did not stimulate inflammatory mediator expression in 3T3-L1 adipocytes.
Thu Jan 01 00:00:00 UTC 2015
NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy.
Molecular cancer therapeutics
Xu C,Buczkowski KA,Zhang Y,Asahina H,Beauchamp EM,Terai H,Li YY,Meyerson M,Wong KK,Hammerman PS
14-4801 was used in Immunohistochemistry to reveal that the discoidin domain receptor 2 gene mutation can drive lung cancer initiation in vivo.
Thu Oct 01 00:00:00 UTC 2015
Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity.
American journal of physiology. Endocrinology and metabolism
Chen Z,Shen H,Sun C,Yin L,Tang F,Zheng P,Liu Y,Brink R,Rui L
14-4801 was used in Flow cytometry/Cell sorting to show that myeloid cell TRAF3 is required for metabolic inflammation and metabolic disease progression in obesity.
Sun Mar 15 00:00:00 UTC 2015
Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity.
American journal of physiology. Endocrinology and metabolism
Chen Z,Shen H,Sun C,Yin L,Tang F,Zheng P,Liu Y,Brink R,Rui L
14-4801 was used in Flow cytometry/Cell sorting to show that myeloid cell TRAF3 is required for metabolic inflammation and metabolic disease progression in obesity.
Sun Mar 15 00:00:00 UTC 2015
Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.
The American journal of pathology
Thuy le TT,Matsumoto Y,Thuy TT,Hai H,Suoh M,Urahara Y,Motoyama H,Fujii H,Tamori A,Kubo S,Takemura S,Morita T,Yoshizato K,Kawada N
14-4801 was used in Immunohistochemistry to clarify the role of cytoglobin in the development of liver fibrosis and cancer in nonalcoholic steatohepatitis.
Wed Apr 01 00:00:00 UTC 2015
Ly6C(high) monocytes control cerebral toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950)
Biswas A,Bruder D,Wolf SA,Jeron A,Mack M,Heimesaat MM,Dunay IR
14-4801 was used in Flow cytometry/Cell sorting to indicate the critical importance of recruited Ly6C monocytes upon cerebral toxoplasmosis.
Wed Apr 01 00:00:00 UTC 2015
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones DD,Wilmore JR,Allman D
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover.
Sun Nov 15 00:00:00 UTC 2015
T follicular helper, but not Th1, cell differentiation in the absence of conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Dahlgren MW,Gustafsson-Hedberg T,Livingston M,Cucak H,Alsén S,Yrlid U,Johansson-Lindbom B
14-4801 was used in Flow cytometry/Cell sorting to investigate the accessory role of conventional DCs during the concurrent development of Tfh and effector Th1 cells.
Mon Jun 01 00:00:00 UTC 2015
Survey of small intestinal and systemic immune responses following murine Arcobacter butzleri infection.
Gut pathogens
Heimesaat MM,Karadas G,Alutis M,Fischer A,Kühl AA,Breithaupt A,Göbel UB,Alter T,Bereswill S,Gölz G
14-4801 was used in Immunohistochemistry to demonstrate a relationship between A. butzleri strain and the influx of distinct immune cell populations upon infection.
Tue Oct 20 00:00:00 UTC 2015
IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.
Cytokine
Sousa LM,Carneiro MB,Dos Santos LM,Natale CC,Resende ME,Mosser DM,Vieira LQ
14-4801 was used in Flow cytometry/Cell sorting to investigate whether or not macrophages are involved in IL-18-mediated susceptibility to L. amazonensis.
Sat Aug 01 00:00:00 UTC 2015
Intracellular Listeria monocytogenes comprises a minimal but vital fraction of the intestinal burden following foodborne infection.
Infection and immunity
Jones GS,Bussell KM,Myers-Morales T,Fieldhouse AM,Bou Ghanem EN,D'Orazio SE
14-4801 was used in Flow cytometry/Cell sorting to investigate how mouse-adapted and wild-type L. monocytogenes strains spread to the mesenteric lymph nodes in a foodborne model of listeriosis.
Sat Aug 01 00:00:00 UTC 2015
A small molecule, odanacatib, inhibits inflammation and bone loss caused by endodontic disease.
Infection and immunity
Hao L,Chen W,McConnell M,Zhu Z,Li S,Reddy M,Eleazer PD,Wang M,Li YP
14-4801 was used in Immunohistochemistry to demonstrate that odanacatib can inhibit endodontic disease development, bone erosion, and immune response.
Wed Apr 01 00:00:00 UTC 2015
Impact of the Pla protease substrate α2-antiplasmin on the progression of primary pneumonic plague.
Infection and immunity
Eddy JL,Schroeder JA,Zimbler DL,Bellows LE,Lathem WW
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that A2AP is not significantly affected by the Pla protease during pneumonic plague.
Tue Dec 01 00:00:00 UTC 2015
The Role of Gelatinases in Campylobacter Jejuni Infection of Gnotobiotic Mice.
European journal of microbiology & immunology
Alutis ME,Grundmann U,Fischer A,Hagen U,Kühl AA,Göbel UB,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to elucidate which gelatinase mediates the intestinal immunopathology following Campylobacter jejuni infection in mice.
Tue Dec 01 00:00:00 UTC 2015
Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch.
PloS one
Tyteca D,Nishino T,Debaix H,Van Der Smissen P,N'Kuli F,Hoffmann D,Cnops Y,Rabolli V,van Loo G,Beyaert R,Huaux F,Devuyst O,Courtoy PJ
14-4801 was used in Flow cytometry/Cell sorting to investigate how AQP1 oppositely regulates macrophage migration, depending on stimulation or not by LPS, and that macrophage phenotypic and migratory changes may be regulated independently of external cues.
Mon Jan 18 00:00:00 UTC 2016
Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver.
Liver international : official journal of the International Association for the Study of the Liver
Alzuguren P,Hervas-Stubbs S,Gonzalez-Aseguinolaza G,Poutou J,Fortes P,Mancheno U,Bunuales M,Olagüe C,Razquin N,Van Rooijen N,Enguita M,Hernandez-Alcoceba R
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to study ways to deplete specific immune cell populations after administration of adenoviral (Ad) vectors and study the impact of cellular and humoral responses on liver-directed gene transfer.
Wed Apr 01 00:00:00 UTC 2015
Assessment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice.
Nanomedicine : nanotechnology, biology, and medicine
Moreno E,Schwartz J,Larrea E,Conde I,Font M,Sanmartín C,Irache JM,Espuelas S
14-4801-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to propose the loading of β-lapachone (β-LP) in lecithin-chitosan nanoparticles (NP) for targeting the drug to the dermis, where infected macrophages reside, and promote wound healing.
Sun Nov 01 00:00:00 UTC 2015
Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation.
PloS one
Mandl M,Drechsler M,Jansen Y,Neideck C,Noels H,Faussner A,Soehnlein O,Weber C,Döring Y
14-4801 was used in Flow cytometry/Cell sorting to investigate how continuous diphtheria toxin-induced pDC depletion in Apoe-/- BDCA2-DTR mice receiving a high-fat diet (HFD) for 4 weeks did not alter lesion size or composition.
Sun May 08 00:00:00 UTC 2016
Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.
Nature communications
Deng Z,Mu J,Tseng M,Wattenberg B,Zhuang X,Egilmez NK,Wang Q,Zhang L,Norris J,Guo H,Yan J,Haribabu B,Miller D,Zhang HG
14-4801 was used in Immunohistochemistry on frozen tissues to investigate interactions that cause inflammation and influence colon cancer progression.
Fri Apr 24 00:00:00 UTC 2015
Toll-Like Receptor-4 Dependent Small Intestinal Immune Responses Following Murine Arcobacter Butzleri Infection.
European journal of microbiology & immunology
Heimesaat MM,Karadas G,Fischer A,Göbel UB,Alter T,Bereswill S,Gölz G
14-4801 was used in Immunohistochemistry to elucidate the involvement of TLR4 during Arcobacter butzleri infection in gnotobiotic mice.
Tue Dec 01 00:00:00 UTC 2015
CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation.
PloS one
Schneider M,Schumacher V,Lischke T,Lücke K,Meyer-Schwesinger C,Velden J,Koch-Nolte F,Mittrücker HW
14-4801 was used in Immunohistochemistry to identify a function for CD38 in the control of inflammatory processes in the colon.
Mon Apr 25 00:00:00 UTC 2016
Toll-Like Receptor-4 is Essential for Arcobacter Butzleri-Induced Colonic and Systemic Immune Responses in Gnotobiotic IL-10(-/-) Mice.
European journal of microbiology & immunology
Gölz G,Karadas G,Fischer A,Göbel UB,Alter T,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to study the immunological involvement of TLR4 and IL-10 during the intestinal and systemic inflammatory response following Arcobacter butzleri infection in mice.
Tue Dec 01 00:00:00 UTC 2015
IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis.
Nature communications
Krause P,Morris V,Greenbaum JA,Park Y,Bjoerheden U,Mikulski Z,Muffley T,Shui JW,Kim G,Cheroutre H,Liu YC,Peters B,Kronenberg M,Murai M
14-4801 was used in Flow cytometry/Cell sorting to indicate a role for intestinal macrophages that constitutively produce IL-10, in controlling innate immune activation after an acute bacterial infection.
Mon May 11 00:00:00 UTC 2015
The nicotinic receptor Alpha7 impacts the mouse lung response to LPS through multiple mechanisms.
PloS one
Enioutina EY,Myers EJ,Tvrdik P,Hoidal JR,Rogers SW,Gahring LC
14-4801-82 was used in Flow Cytometry to examine the mechanisms of the lung inflammatory response to intranasal lipopolysaccharide, regulated by α7 in mice.
Thu Apr 07 00:00:00 UTC 2016
Testing the role of the FcγRIIB immunoreceptor tyrosine-based inhibitory motif in regulation of the B cell immune response.
Immunity, inflammation and disease
Vuyyuru R,Shen S,Manser T
14-4801 was used in Flow cytometry/Cell sorting to test the role of the FcγRIIB ITIM motif in the regulation of B cell immune response in vivo, showing that a functional ITIM motif is not required for all inhibitory activity of this receptor, however further investigation is required to confirm this.
Tue Sep 01 00:00:00 UTC 2015
CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.
Nature communications
Huang QQ,Perlman H,Birkett R,Doyle R,Fang D,Haines GK,Robinson W,Datta S,Huang Z,Li QZ,Phee H,Pope RM
14-4801 was used in Immunohistochemistry to investigate the effect of Flip deletion in dendritic cells.
Tue May 12 00:00:00 UTC 2015
Preventive Anti-CD2 Treatment does not Impair Parasite Control in a Murine Toxoplasmosis Model.
European journal of microbiology & immunology
Erben U,Pawlowski NN,Heimesaat MM,Loddenkemper C,Doerfel K,Spieckermann S,Siegmund B,Kühl AA
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to investigate whether the anti-CD2 monoclonal antibody CB.219 has adverse effects on infection control.
Tue Dec 01 00:00:00 UTC 2015
Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.
Scientific reports
Fu Y,Cruz-Monserrate Z,Helen Lin H,Chung Y,Ji B,Lin SM,Vonderfecht S,Logsdon CD,Li CF,Ann DK
14-4801 was used in Immunohistochemistry to study the significance of the somatic KRAS A146T and Q61H mutations in salivary duct carcinoma.
Thu Aug 20 00:00:00 UTC 2015
Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment.
Neoplasia (New York, N.Y.)
McDonald LT,Russell DL,Kelly RR,Xiong Y,Motamarry A,Patel RK,Jones JA,Watson PM,Turner DP,Watson DK,Soloff AC,Findlay VJ,LaRue AC
14-4801 was used in Immunofluorescence to investigate whether HSC-CAFs promote tumour progression, showing that they are novel contributors to the pro-tumourigenic microenvironment.
Fri May 01 00:00:00 UTC 2015
IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut.
Scientific reports
Goto Y,Lamichhane A,Kamioka M,Sato S,Honda K,Kunisawa J,Kiyono H
14-4801 was used in Flow cytometry/Cell sorting to study the contribution of IL-10 producing CD4+ T cells to the maintenance of epithelial cell function by regulating fucosylation..
Mon Nov 02 00:00:00 UTC 2015
Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia.
Nature communications
Li J,van der Wal DE,Zhu G,Xu M,Yougbare I,Ma L,Vadasz B,Carrim N,Grozovsky R,Ruan M,Zhu L,Zeng Q,Tao L,Zhai ZM,Peng J,Hou M,Leytin V,Freedman J,Hoffmeister KM,Ni H
Fri Jul 17 00:00:00 UTC 2015
Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.
Scientific reports
Moniaga CS,Watanabe S,Honda T,Nielsen S,Hara-Chikuma M
14-4801 was used in Flow cytometry/Cell sorting to suggest that AQP9 is required for the development of sensitisation during cutaneous acquired immune responses via regulating neutrophil function.
Thu Oct 22 00:00:00 UTC 2015
Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.
Respiratory research
Sureshbabu A,Syed MA,Boddupalli CS,Dhodapkar MV,Homer RJ,Minoo P,Bhandari V
14-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms responsible for TGFβ1-induced inflammatory signals leading to abnormal alveolarization, showing that it promotes pulmonary inflammation, apoptosis and mortality via TGFβR2.
Fri Jan 16 00:00:00 UTC 2015
Blockade of Interplay between IL-17A and Endoplasmic Reticulum Stress Attenuates LPS-Induced Lung Injury.
Theranostics
Kim SR,Kim HJ,Kim DI,Lee KB,Park HJ,Jeong JS,Cho SH,Lee YC
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of IL-17A in LPS-induced lung injury, focusing on the link with ER stress.
Thu Aug 04 00:00:00 UTC 2016
Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies.
Nature communications
Fukuyama S,Katsura H,Zhao D,Ozawa M,Ando T,Shoemaker JE,Ishikawa I,Yamada S,Neumann G,Watanabe S,Kitano H,Kawaoka Y
14-4801 was used in Flow cytometry/Cell sorting to investigate influenza pathogenesis using influenza viruses expressing fluorescent proteins of different colours.
Wed Mar 25 00:00:00 UTC 2015
Arcobacter butzleri Induce Colonic, Extra-Intestinal and Systemic Inflammatory Responses in Gnotobiotic IL-10 Deficient Mice in a Strain-Dependent Manner.
PloS one
Gölz G,Karadas G,Alutis ME,Fischer A,Kühl AA,Breithaupt A,Göbel UB,Alter T,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to demonstrate that A. butzleri infection results in the expansion of distinct immune cell populations in the colon.
Mon May 30 00:00:00 UTC 2016
Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.
Cell metabolism
Gordts PLSM,Foley EM,Lawrence R,Sinha R,Lameda-Diaz C,Deng L,Nock R,Glass CK,Erbilgin A,Lusis AJ,Witztum JL,Esko JD
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of heparan sulfate proteoglycans in atherogenesis, showing that reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity.
Tue Nov 04 00:00:00 UTC 2014
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Nature immunology
Franklin BS,Bossaller L,De Nardo D,Ratter JM,Stutz A,Engels G,Brenker C,Nordhoff M,Mirandola SR,Al-Amoudi A,Mangan MS,Zimmer S,Monks BG,Fricke M,Schmidt RE,Espevik T,Jones B,Jarnicki AG,Hansbro PM,Busto P,Marshak-Rothstein A,Hornemann S,Aguzzi A,Kastenmüller W,Latz E
14-4801 was used in Flow cytometry/Cell sorting to study the behaviour of ASC specks and their contribution to IL-1β - induced inflammation.
Fri Aug 01 00:00:00 UTC 2014
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
Nature immunology
Huang SC,Everts B,Ivanova Y,O'Sullivan D,Nascimento M,Smith AM,Beatty W,Love-Gregory L,Lam WY,O'Neill CM,Yan C,Du H,Abumrad NA,Urban JF,Artyomov MN,Pearce EL,Pearce EJ
14-4801 was used in Flow cytometry/Cell sorting to delineate a critical role for cell-intrinsic lysosomal lipolysis in M2 activation.
Mon Sep 01 00:00:00 UTC 2014
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
Nature immunology
Khare S,Ratsimandresy RA,de Almeida L,Cuda CM,Rellick SL,Misharin AV,Wallin MC,Gangopadhyay A,Forte E,Gottwein E,Perlman H,Reed JC,Greaves DR,Dorfleutner A,Stehlik C
14-4801 was used in Flow cytometry/Cell sorting to study the molecular mechanisms regulating the activation of the innate immune response to viral DNA.
Tue Apr 01 00:00:00 UTC 2014
CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.
The Journal of clinical investigation
Nouailles G,Dorhoi A,Koch M,Zerrahn J,Weiner J,Faé KC,Arrey F,Kuhlmann S,Bandermann S,Loewe D,Mollenkopf HJ,Vogelzang A,Meyer-Schwesinger C,Mittrücker HW,McEwen G,Kaufmann SH
14-4801 was used in Flow cytometry/Cell sorting to investigate expression of genes encoding CXC chemokines in M. tuberculosis-infected murine lung tissue.
Sat Mar 01 00:00:00 UTC 2014
Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury.
Kidney international
Li J,Xu Z,Jiang L,Mao J,Zeng Z,Fang L,He W,Yuan W,Yang J,Dai C
14-4801 was used in Immunohistochemistry to investigate the function and mechanisms of Rictor/mTORC2 in regulating tubular cell survival and acute kidney injury using knockout mice.
Tue Jul 01 00:00:00 UTC 2014
Progressive replacement of embryo-derived cardiac macrophages with age.
The Journal of experimental medicine
Molawi K,Wolf Y,Kandalla PK,Favret J,Hagemeyer N,Frenzel K,Pinto AR,Klapproth K,Henri S,Malissen B,Rodewald HR,Rosenthal NA,Bajenoff M,Prinz M,Jung S,Sieweke MH
14-4801 was used in Flow cytometry/Cell sorting to report that the embryo-derived population of cardiac macrophages is progressively substituted for monocyte-derived macrophages within the first weeks after birth.
Mon Oct 20 00:00:00 UTC 2014
IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.
Journal of autoimmunity
Hodge DL,Berthet C,Coppola V,Kastenmüller W,Buschman MD,Schaughency PM,Shirota H,Scarzello AJ,Subleski JJ,Anver MR,Ortaldo JR,Lin F,Reynolds DA,Sanford ME,Kaldis P,Tessarollo L,Klinman DM,Young HA
14-4801 was used in Immunohistochemistry-immunofluorescence to study the effects of a 162 nucleotide AU-rich element region deletion in the 3' untranslated region of the interferon-gamma gene in mice.
Mon Sep 01 00:00:00 UTC 2014
Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.
EMBO molecular medicine
Diana J,Lehuen A
14-4801 was used in Flow cytometry/Cell sorting to determine the cellular and molecular mechanisms leading to the recruitment of neutrophils in the pancreatic islets of non-obese diabetic mice.
Fri Aug 01 00:00:00 UTC 2014
Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.
Proceedings of the National Academy of Sciences of the United States of America
Lee WY,Sanz MJ,Wong CH,Hardy PO,Salman-Dilgimen A,Moriarty TJ,Chaconas G,Marques A,Krawetz R,Mody CH,Kubes P
14-4801 was used in Flow cytometry/Cell sorting to demonstrate a novel, critical extravascular invariant natural killer T cell-mediated mechanism of immune surveillance in joints.
Tue Sep 23 00:00:00 UTC 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-4801 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 UTC 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
14-4801 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 UTC 2014
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.
Mucosal immunology
Chan IH,Jain R,Tessmer MS,Gorman D,Mangadu R,Sathe M,Vives F,Moon C,Penaflor E,Turner S,Ayanoglu G,Chang C,Basham B,Mumm JB,Pierce RH,Yearley JH,McClanahan TK,Phillips JH,Cua DJ,Bowman EP,Kastelein RA,LaFace D
14-4801 was used in Immunohistochemistry to reveal an explicit role for IL-23-mediated initiation of gut tumorigenesis and implicate a key role for IL-23R(+) ILC3 in the absence of overt cellular infiltrate recruitment.
Tue Jul 01 00:00:00 UTC 2014
Soluble CD83 ameliorates experimental colitis in mice.
Mucosal immunology
Eckhardt J,Kreiser S,Döbbeler M,Nicolette C,DeBenedette MA,Tcherepanova IY,Ostalecki C,Pommer AJ,Becker C,Günther C,Zinser E,Mak TW,Steinkasserer A,Lechmann M
14-4801 was used in Flow cytometry/Cell sorting to investigate new strategies for treatment of IBD, showing that soluble CD83 ameliorates experimental colitis in mice.
Tue Jul 01 00:00:00 UTC 2014
Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis.
PLoS pathogens
Nascimento M,Huang SC,Smith A,Everts B,Lam W,Bassity E,Gautier EL,Randolph GJ,Pearce EJ
14-4801 was used in Flow cytometry/Cell sorting to show monocyte recruitment as the dominant process for increasing macrophage cell numbers in the liver during schistosomiasis.
Fri Aug 01 00:00:00 UTC 2014
Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner.
PLoS pathogens
Kasper KJ,Zeppa JJ,Wakabayashi AT,Xu SX,Mazzuca DM,Welch I,Baroja ML,Kotb M,Cairns E,Cleary PP,Haeryfar SM,McCormick JK
14-4801 was used in Flow cytometry/Cell sorting to study how secreted superantigens contribute to the fitness and evolution of S. pyogenes.
Thu May 01 00:00:00 UTC 2014
Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency.
Journal of innate immunity
Ayala A,Elphick GF,Kim YS,Huang X,Carreira-Rosario A,Santos SC,Shubin NJ,Chen Y,Reichner J,Chung CS
14-4801 was used in Flow cytometry/Cell sorting to investigate the effect of programmed cell death receptor-1 in mediating aspects of innate macrophage immune dysfunction during sepsis.
Mon May 11 00:00:00 UTC 2015
Paradoxical resistance to high-fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor-overexpressing mice.
American journal of physiology. Endocrinology and metabolism
Kuhn E,Bourgeois C,Keo V,Viengchareun S,Muscat A,Meduri G,Le Menuet D,Fève B,Lombès M
14-4801 was used in Flow cytometry/Cell sorting to investigate the in vivo metabolic impact of the mineralocorticoid receptor (MR), showing that overexpression of MR leads to resistance to high-fat diet-induced obesity and altered macrophage polarisation.
Wed Jan 01 00:00:00 UTC 2014
Roles of mast cells in the pathogenesis of inflammatory myopathy.
Arthritis research & therapy
Yokota M,Suzuki K,Tokoyoda K,Meguro K,Hosokawa J,Tanaka S,Ikeda K,Mikata T,Nakayama T,Kohsaka H,Nakajima H
14-4801 was used in Immunohistochemistry to determine that mast cells are involved in the pathogenesis of inflammatory myopathy.
Mon Mar 17 00:00:00 UTC 2014
Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ
14-4801 was used in Flow cytometry/Cell sorting to define the expression profile, scavenging activity, and ligand specificity of CCL2 receptors on mouse leukocytes.
Tue Jul 01 00:00:00 UTC 2014
The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Chung JS,Tamura K,Akiyoshi H,Cruz PD,Ariizumi K
14-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of autoimmune responses in experimental autoimmune encephalomyelitis.
Sat Mar 15 00:00:00 UTC 2014
Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Arina A,Schreiber K,Binder DC,Karrison TG,Liu RB,Schreiber H
14-4801 was used in Flow cytometry/Cell sorting to study the effect of adoptively transferred immune T cells in the presence of MDSCs and TAMs on established tumours, showing that they are eradicated.
Sat Feb 01 00:00:00 UTC 2014
IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.
Journal of immunology (Baltimore, Md. : 1950)
Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K
14-4801 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.
Sat Mar 01 00:00:00 UTC 2014
Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors.
Journal of immunology (Baltimore, Md. : 1950)
Chernova I,Jones DD,Wilmore JR,Bortnick A,Yucel M,Hershberg U,Allman D
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of subpopulations of bone marrow plasma cells in long-term humoral responses to T cell-dependent Ag.
Sat Nov 15 00:00:00 UTC 2014
The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.
Gut pathogens
Bereswill S,Kühl AA,Alutis M,Fischer A,Möhle L,Struck D,Liesenfeld O,Göbel UB,Dunay IR,Heimesaat MM
14-4801 was used in Immunohistochemistry to study the role of TLR-9 during development of T. gondii infection.
Mon Jun 16 00:00:00 UTC 2014
Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii.
International journal for parasitology
Patil V,Zhao Y,Shah S,Fox BA,Rommereim LM,Bzik DJ,Yap GS
14-4801 was used in Flow cytometry/Cell sorting to highlight the multi-functionality of macrophages as they respond to diverse microbial and endogenous stimuli.
Sat Feb 01 00:00:00 UTC 2014
Yersinia pseudotuberculosis efficiently escapes polymorphonuclear neutrophils during early infection.
Infection and immunity
Westermark L,Fahlgren A,Fällman M
14-4801 was used in Flow cytometry/Cell sorting to analyse bacterium-immune cell interactions in the intestinal lymphoid tissues of mice during early Yersinia pseudotuberculosis infection.
Sat Mar 01 00:00:00 UTC 2014
A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Ibrahim MM,Bond J,Bergeron A,Miller KJ,Ehanire T,Quiles C,Lorden ER,Medina MA,Fisher M,Klitzman B,Selim MA,Leong KW,Levinson H
14-4801 was used in Immunocytochemistry to develop a validated, immune-competent, murine hypertrophic scar model.
Wed Dec 30 00:00:00 UTC 2015
A mushroom extract Piwep from Phellinus igniarius ameliorates experimental autoimmune encephalomyelitis by inhibiting immune cell infiltration in the spinal cord.
BioMed research international
Li L,Wu G,Choi BY,Jang BG,Kim JH,Sung GH,Cho JY,Suh SW,Park HJ
14-4801 was used in Immunohistochemistry to evaluate the therapeutic potential of a mushroom extract from Phellinus igniarius in an animal model of multiple sclerosis.
Wed Dec 24 00:00:00 UTC 2014
CD3 antibody and IL-2 complex combination therapy inhibits atherosclerosis by augmenting a regulatory immune response.
Journal of the American Heart Association
Kasahara K,Sasaki N,Yamashita T,Kita T,Yodoi K,Sasaki Y,Takeda M,Hirata K
14-4801 was used in Flow cytometry/Cell sorting to investigate the inhibition of atherosclerosis by a CD3 antibody and IL-2 complex combination.
Tue Apr 22 00:00:00 UTC 2014
Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome.
PloS one
Alawadhi F,Du H,Cakmak H,Taylor HS
14-4801 was used in Immunofluorescence to demonstrate that BMDSCs are recruited to endometrium in response to injury, with a role in uterine repair.
Fri Jan 23 00:00:00 UTC 2015
VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment.
Vascular cell
Douglas NC,Zimmermann RC,Tan QK,Sullivan-Pyke CS,Sauer MV,Kitajewski JK,Shawber CJ
14-4801 was used in Immunohistochemistry to find that VEGFR-1 functions in both decidual angiogenesis and macrophage recruitment to the implantation site during pregnancy.
Thu Aug 07 00:00:00 UTC 2014
Caspase-3 mediates the pathogenic effect of Yersinia pestis YopM in liver of C57BL/6 mice and contributes to YopM's function in spleen.
PloS one
Ye Z,Gorman AA,Uittenbogaard AM,Myers-Morales T,Kaplan AM,Cohen DA,Straley SC
14-4801 was used in Immunohistochemistry to investigate the dominant effect of the virulence protein YopM of the plague bacterium Yersinia pestis on the liver.
Mon Jun 29 00:00:00 UTC 2015
Prostatic inflammation induces fibrosis in a mouse model of chronic bacterial infection.
PloS one
Wong L,Hutson PR,Bushman W
14-4801 was used in Immunohistochemistry to how that chronic prostatic inflammation induces collagen deposition and implicates fibrocytes in the fibrotic process.
Tue Oct 13 00:00:00 UTC 2015
Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.
Nature communications
Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A
14-4801 was used in Flow cytometry/Cell sorting to study whether epigenetic modifications affecting T-cells persist following adoptive transfer of the cells.
Fri Mar 28 00:00:00 UTC 2014
The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.
PloS one
Sauter KA,Pridans C,Sehgal A,Bain CC,Scott C,Moffat L,Rojo R,Stutchfield BM,Davies CL,Donaldson DS,Renault K,McColl BW,Mowat AM,Serrels A,Frame MC,Mabbott NA,Hume DA
14-4801 was used in Flow cytometry/Cell sorting to examine expression of the MacBlue transgene in embryos and adult mice.
Fri Dec 18 00:00:00 UTC 2015
Selective gelatinase inhibition reduces apoptosis and pro-inflammatory immune cell responses in Campylobacter jejuni-infected gnotobiotic IL-10 deficient mice.
European journal of microbiology & immunology
Alutis ME,Grundmann U,Fischer A,Kühl AA,Bereswill S,Heimesaat MM
Mon Dec 01 00:00:00 UTC 2014
Pituitary adenylate cyclase-activating polypeptide ameliorates experimental acute ileitis and extra-intestinal sequelae.
PloS one
Heimesaat MM,Dunay IR,Schulze S,Fischer A,Grundmann U,Alutis M,Kühl AA,Tamas A,Toth G,Dunay MP,Göbel UB,Reglodi D,Bereswill S
Mon Nov 16 00:00:00 UTC 2015
Impact of Campylobacter jejuni cj0268c knockout mutation on intestinal colonization, translocation, and induction of immunopathology in gnotobiotic IL-10 deficient mice.
PloS one
Heimesaat MM,Lugert R,Fischer A,Alutis M,Kühl AA,Zautner AE,Tareen AM,Göbel UB,Bereswill S
14-4801 was used in Immunohistochemistry to show that the cj0268c gene is involved in mediating C. jejuni induced immunopathogenesis in vivo.
Thu Oct 16 00:00:00 UTC 2014
Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice.
PloS one
Chen L,Xu Y,Zhao J,Zhang Z,Yang R,Xie J,Liu X,Qi S
14-4801 was used in Immunohistochemistry to suggest that bone marrow-derived mesenchymal stem cells promote murine skin wound healing via hypoxia-enhanced paracrine molecules.
Thu Jan 22 00:00:00 UTC 2015
Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.
PloS one
Tilstam PV,Gijbels MJ,Habbeddine M,Cudejko C,Asare Y,Theelen W,Zhou B,Döring Y,Drechsler M,Pawig L,Simsekyilmaz S,Koenen RR,de Winther MP,Lawrence T,Bernhagen J,Zernecke A,Weber C,Noels H
14-4801 was used in Flow cytometry/Cell sorting to reveal an important and previously unrecognized role of haematopoietic Ikkα kinase activation in the homeostasis of B-cells and regulatory T-cells.
Wed Dec 03 00:00:00 UTC 2014
Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners.
PloS one
Bruner-Tran KL,Ding T,Yeoman KB,Archibong A,Arosh JA,Osteen KG
14-4801 was used in Immunohistochemistry to suggest that the preconception testicular health of the father is a critical determinant of pregnancy outcomes in mice.
Tue Dec 15 00:00:00 UTC 2015
Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages.
Stem cell research & therapy
Geng Y,Zhang L,Fu B,Zhang J,Hong Q,Hu J,Li D,Luo C,Cui S,Zhu F,Chen X
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate the protective effects of macrophage activation in mesenchymal stem cell therapy of rhabdomyolysis-induced acute kidney injury.
Tue Jun 24 00:00:00 UTC 2014
Tetanus toxoid-pulsed monocyte vaccination for augmentation of collateral vessel growth.
Journal of the American Heart Association
Herold J,Francke A,Weinert S,Schmeisser A,Hebel K,Schraven B,Roehl FW,Strasser RH,Braun-Dullaeus RC
14-4801 was used in Immunofluorescence on frozen tissues to investigate the effect of tetanus toxoid on augmentation of arteriogenesis.
Mon Apr 14 00:00:00 UTC 2014
Synergistic effects of glycated chitosan with high-intensity focused ultrasound on suppression of metastases in a syngeneic breast tumor model.
Cell death & disease
Chen YL,Wang CY,Yang FY,Wang BS,Chen JY,Lin LT,Leu JD,Chiu SJ,Chen FD,Lee YJ,Chen WR
14-4801 was used in Immunohistochemistry to suggest that GC alone can reduce cancer cell motility and invasion, whereas GC-HIFU treatment can induce immune responses to suppress tumor metastasis in vivo.
Thu Apr 17 00:00:00 UTC 2014
A Single B-repeat of Staphylococcus epidermidis accumulation-associated protein induces protective immune responses in an experimental biomaterial-associated infection mouse model.
Clinical and vaccine immunology : CVI
Yan L,Zhang L,Ma H,Chiu D,Bryers JD
14-4801 was used in Immunocytochemistry-immunoflourescence to evaluate the efficacy of a small recombinant protein vaccine against a component of the S. epidermidis cell wall, in a mouse model.
Mon Sep 01 00:00:00 UTC 2014
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Cell host & microbe
Hickman HD,Reynoso GV,Ngudiankama BF,Rubin EJ,Magadán JG,Cush SS,Gibbs J,Molon B,Bronte V,Bennink JR,Yewdell JW
14-4801 was used in Flow cytometry/Cell sorting to explore the spatiotemporal organization between antiviral immune cells and vaccinia virus-infected murine cells.
Wed Feb 13 00:00:00 UTC 2013
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-4801 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 UTC 2013
The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo.
Blood
Morrison VL,MacPherson M,Savinko T,Lek HS,Prescott A,Fagerholm SC
14-4801 was used in Flow cytometry/Cell sorting to study the implications of a mutated kindlin-3 binding site in β2 integrins in T-cell adhesion and homing responses.
Thu Aug 22 00:00:00 UTC 2013
Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells.
Blood
Pasquet L,Douet JY,Sparwasser T,Romagnoli P,van Meerwijk JP
14-4801 was used in Flow cytometry/Cell sorting to assess if persistence of administered regulatory T cells is required for long-term maintenance of tolerance to allografts.
Thu May 23 00:00:00 UTC 2013
Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution.
Blood
Kellermair J,Redwan B,Alias S,Jabkowski J,Panzenboeck A,Kellermair L,Winter MP,Weltermann A,Lang IM
14-4801 was used in Immunohistochemistry to investigate the effect of PECAM-1 deficiency on thrombus resolution in FVB/n mice, and the extent to which levels of soluble PECAM-1 correlate with delayed thrombus resolution in humans after acute symptomatic deep vein thrombosis.
Thu Nov 07 00:00:00 UTC 2013
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke.
Circulation research
Ludewig P,Sedlacik J,Gelderblom M,Bernreuther C,Korkusuz Y,Wagener C,Gerloff C,Fiehler J,Magnus T,Horst AK
14-4801 was used in Flow cytometry/Cell sorting to identify and characterise the relevance of CEACAM1-expressing inflammatory cells in blood-brain-barrier breakdown.
Fri Sep 27 00:00:00 UTC 2013
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke.
Circulation research
Ludewig P,Sedlacik J,Gelderblom M,Bernreuther C,Korkusuz Y,Wagener C,Gerloff C,Fiehler J,Magnus T,Horst AK
14-4801 was used in Flow cytometry/Cell sorting to identify and characterise the relevance of CEACAM1-expressing inflammatory cells in blood-brain-barrier breakdown.
Fri Sep 27 00:00:00 UTC 2013
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.
The Journal of clinical investigation
Kansara M,Leong HS,Lin DM,Popkiss S,Pang P,Garsed DW,Walkley CR,Cullinane C,Ellul J,Haynes NM,Hicks R,Kuijjer ML,Cleton-Jansen AM,Hinds PW,Smyth MJ,Thomas DM
14-4801 was used in Flow cytometry/Cell sorting to indicate that overcoming the immune response to senescence is a rate-limiting step in the formation of IR-induced osteosarcoma.
Sun Dec 01 00:00:00 UTC 2013
A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis.
Kidney international
Jiang L,Qiu W,Zhou Y,Wen P,Fang L,Cao H,Zen K,He W,Zhang C,Dai C,Yang J
14-4801 was used in Immunohistochemistry to study how the miR-30e/UCP2 axis has an important role in mediating TGF-β1-induced epithelial-mesenchymal transition and kidney fibrosis.
Thu Aug 01 00:00:00 UTC 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-4801 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 UTC 2013
Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear.
Nature protocols
Neng L,Zhang W,Hassan A,Zemla M,Kachelmeier A,Fridberger A,Auer M,Shi X
14-4801 was used in Immunocytochemistry to produce highly purified primary cell lines which enable cell culture-based in vitro modeling of cell-cell interactions, barrier control function and drug action.
Mon Apr 01 00:00:00 UTC 2013
IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells.
Journal of the American Society of Nephrology : JASN
Kim MG,Koo TY,Yan JJ,Lee E,Han KH,Jeong JC,Ro H,Kim BS,Jo SK,Oh KH,Surh CD,Ahn C,Yang J
14-4801 was used in Immunohistochemistry to evaluate IL-2C as a therapeutic strategy for the attenuation of acute kidney injury.
Tue Oct 01 00:00:00 UTC 2013
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.
Cancer research
Baird JR,Fox BA,Sanders KL,Lizotte PH,Cubillos-Ruiz JR,Scarlett UK,Rutkowski MR,Conejo-Garcia JR,Fiering S,Bzik DJ
14-4801 was used in Flow cytometry/Cell sorting to establish that cps preferentially invades tumour-associated antigen-presenting cells and restores their ability to trigger potent anti-tumour CD8(+) T-cell responses.
Mon Jul 01 00:00:00 UTC 2013
M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.
The Journal of cell biology
Madsen DH,Leonard D,Masedunskas A,Moyer A,Jürgensen HJ,Peters DE,Amornphimoltham P,Selvaraj A,Yamada SS,Brenner DA,Burgdorf S,Engelholm LH,Behrendt N,Holmbeck K,Weigert R,Bugge TH
Mon Sep 16 00:00:00 UTC 2013
Differential effects of the CpG-Toll-like receptor 9 axis on pregnancy outcome in nonobese diabetic mice and wild-type controls.
Fertility and sterility
Sun Y,Qin X,Shan B,Wang W,Zhu Q,Sharma S,Wu J,Lin Y
14-4801-82 was used in Functional assay to elucidate the relationship between CpG-induced activation of innate immunity and pregnancy outcome.
Wed May 01 00:00:00 UTC 2013
Persistently active microbial molecules prolong innate immune tolerance in vivo.
PLoS pathogens
Lu M,Varley AW,Munford RS
14-4801 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism for tolerance reprogramming following exposure to Gram-negative bacteria.
Wed May 01 00:00:00 UTC 2013
Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages.
European journal of immunology
Zhang W,Wang X,Xia X,Liu X,Suo S,Guo J,Li M,Cao W,Cai Z,Hui Z,Subramaniam M,Spelsberg TC,Wang J,Wang L
14-4801 was used in Flow cytometry/Cell sorting to identify Klf10 as a transcription factor that regulates the expression of IL-12p40 in bone marrow-derived macrophages.
Tue Jan 01 00:00:00 UTC 2013
Traumatic brain injury induces macrophage subsets in the brain.
European journal of immunology
Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE
14-4801 was used in Immunohistochemistry to better understand the mechanisms involved in the innate inflammatory responses to brain injury.
Thu Aug 01 00:00:00 UTC 2013
Perivascular macrophage-like melanocyte responsiveness to acoustic trauma--a salient feature of strial barrier associated hearing loss.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang F,Dai M,Neng L,Zhang JH,Zhi Z,Fridberger A,Shi X
14-4801-82 was used in Immunohistochemistry to demonstrate that delivery of PEDF to the damaged ear ameliorates hearing loss by restoring intrastrial fluid-blood barrier integrity.
Sun Sep 01 00:00:00 UTC 2013
Adrenomedullin gene dosage correlates with tumor and lymph node lymphangiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Karpinich NO,Kechele DO,Espenschied ST,Willcockson HH,Fedoriw Y,Caron KM
14-4801 was used in Immunohistochemistry to evaluate whether modulating adrenomedullin gene dosage within tumour cells affects lympangiogenesis.
Fri Feb 01 00:00:00 UTC 2013
Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction.
The American journal of pathology
Seropian IM,Cerliani JP,Toldo S,Van Tassell BW,Ilarregui JM,González GE,Matoso M,Salloum FN,Melchior R,Gelpi RJ,Stupirski JC,Benatar A,Gómez KA,Morales C,Abbate A,Rabinovich GA
14-4801 was used in Immunofluorescence to investigate the role of Gal-1 in modulating heart pathophysiology.
Tue Jan 01 00:00:00 UTC 2013
Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Zeng XL,Nagavalli A,Smith CJ,Howard JF,Su MA
14-4801 was used in Immunohistochemistry to reveal distinct and opposing effects of the T cell costimulatory pathway and IFN-γ production on the pathogenesis of autoimmune peripheral neuropathy.
Mon Apr 15 00:00:00 UTC 2013
FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.
Molecular and cellular biology
Ren X,Shah TA,Ustiyan V,Zhang Y,Shinn J,Chen G,Whitsett JA,Kalin TV,Kalinichenko VV
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of transcriptional control of goblet cell differentiation and mucus hyperproduction, showing that FOXM1 promotes allergen-induced metaplasia and pulmonary inflammation.
Tue Jan 01 00:00:00 UTC 2013
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Molecular and cellular biology
Zhong MC,Veillette A
14-4801 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.
Fri Mar 01 00:00:00 UTC 2013
Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD
14-4801 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.
Tue Jan 01 00:00:00 UTC 2013
Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect.
Translational oncology
Yang Y,Wang X,Huycke T,Moore DR,Lightfoot SA,Huycke MM
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to investigate whether colon macrophages are key effectors for the bystander effect.
Wed Oct 23 00:00:00 UTC 2013
Proangiogenic TIE2(+)/CD31 (+) macrophages are the predominant population of tumor-associated macrophages infiltrating metastatic lymph nodes.
Molecules and cells
Kim OH,Kang GH,Noh H,Cha JY,Lee HJ,Yoon JH,Mamura M,Nam JS,Lee DH,Kim YA,Park YJ,Kim H,Oh BC
14-4801 was used in Immunohistochemistry to show that tumour associated macrophages localise in GFP-labelled tumours of metastatic lymph nodes from B16F1 melanoma cells but not necrotic tumour regions.
Fri Nov 01 00:00:00 UTC 2013
SAP modulates B cell functions in a genetic background-dependent manner.
Immunology letters
Detre C,Yigit B,Keszei M,Castro W,Magelky EM,Terhorst C
14-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism by which SLAM-associated protein modulates B cell functions.
Sat Jun 01 00:00:00 UTC 2013
Transplantation of bone marrow derived monocytes: a novel approach for augmentation of arteriogenesis in a murine model of femoral artery ligation.
American journal of translational research
Francke A,Weinert S,Strasser RH,Braun-Dullaeus RC,Herold J
14-4801 was used in Immunofluorescence to demonstrate murine allogeneic monocytes to be effective in triggering local inflammatory responses near growing collateral vessels.
Thu Apr 11 00:00:00 UTC 2013
Endothelial cell, pericyte, and perivascular resident macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability.
Journal of the Association for Research in Otolaryngology : JARO
Neng L,Zhang F,Kachelmeier A,Shi X
Mon Apr 01 00:00:00 UTC 2013
TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Developmental biology
Bai X,Trowbridge JJ,Riley E,Lee JA,DiBiase A,Kaartinen VM,Orkin SH,Zon LI
14-4801 was used in Flow cytometry/Cell sorting to study the role of TIF1γ in murine erythropoiesis and to assess its function in other blood lineages.
Tue Jan 15 00:00:00 UTC 2013
Macrophages are involved in the protective role of human umbilical cord-derived stromal cells in renal ischemia-reperfusion injury.
Stem cell research
Li W,Zhang Q,Wang M,Wu H,Mao F,Zhang B,Ji R,Gao S,Sun Z,Zhu W,Qian H,Chen Y,Xu W
14-4801 was used in Immunohistochemistry to investigate the involvement of macrophages in the therapeutic effect of human umbilical cord-derived stromal cells on renal ischemia-reperfusion injury.
Wed May 01 00:00:00 UTC 2013
Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection.
PloS one
Obregón-Henao A,Henao-Tamayo M,Orme IM,Ordway DJ
14-4801 was used in Flow cytometry/Cell sorting to compare the bacterial burden, lung pathology and Gr1(int)CD11b(+) myeloid-derived suppressor cell immune responses in M. tuberculosis infected mice.
Fri Jun 20 00:00:00 UTC 2014
Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway.
Nature communications
Ouyang X,Ghani A,Malik A,Wilder T,Colegio OR,Flavell RA,Cronstein BN,Mehal WZ
14-4801 was used in Flow cytometry/Cell sorting to reveal that inflammasome activity is sustained after initial activation, by A(2A) receptor-mediated signalling.
Tue Jul 08 00:00:00 UTC 2014
CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network.
Neoplasia (New York, N.Y.)
Boissonnas A,Licata F,Poupel L,Jacquelin S,Fetler L,Krumeich S,Théry C,Amigorena S,Combadière C
14-4801 was used in Flow cytometry/Cell sorting to examine the spatiotemporal interactions between tumor-infiltrating lymphocytes and tumor dendritic cells after chemotherapy.
Tue Jan 01 00:00:00 UTC 2013
Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation.
Scientific reports
Swindell WR,Johnston A,Xing X,Little A,Robichaud P,Voorhees JJ,Fisher G,Gudjonsson JE
14-4801 was used in Immunohistochemistry to investigate the involvement of the S100a8/a9 genes in the basic mechanisms of intrinsic ageing.
Wed Aug 14 00:00:00 UTC 2013
Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis.
PloS one
Harmel-Laws E,Mann EA,Cohen MB,Steinbrecher KA
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate the impact of guanylate cyclase C (GC-C; Gucy2c) activity on mucosal immune responses.
Mon Aug 18 00:00:00 UTC 2014
Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy.
PloS one
Xiao H,Shen HY,Liu W,Xiong RP,Li P,Meng G,Yang N,Chen X,Si LY,Zhou YG
14-4801 was used in Immunohistochemistry to demonstrate that activation of A2AR effectively alleviates epithelial-mesenchymal transition and renal interstitial fibrosis in mice.
Tue Oct 22 00:00:00 UTC 2013
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease.
The Journal of biological chemistry
McMahan RH,Wang XX,Cheng LL,Krisko T,Smith M,El Kasmi K,Pruzanski M,Adorini L,Golden-Mason L,Levi M,Rosen HR
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that FXR/TGR5 activation coordinates the immune phenotype of monocytes and macrophages.
Fri Apr 26 00:00:00 UTC 2013
Foxp3+ regulatory T cells are required for recovery from severe sepsis.
PloS one
Kühlhorn F,Rath M,Schmoeckel K,Cziupka K,Nguyen HH,Hildebrandt P,Hünig T,Sparwasser T,Huehn J,Pötschke C,Bröker BM
14-4801 was used in Flow cytometry/Cell sorting to determine the sufficiency of the suppressive capacity of Tregs for controlling inflammation due to sepsis.
Fri Jan 10 00:00:00 UTC 2014
Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage.
PloS one
Gahring LC,Enioutina EY,Myers EJ,Spangrude GJ,Efimova OV,Kelley TW,Tvrdik P,Capecchi MR,Rogers SW
14-4801 was used in Flow cytometry/Cell sorting to investigate how inflammatory responses are mechanistically modulated by nicotinic acetylcholine receptors.
Tue Aug 27 00:00:00 UTC 2013
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.
The Journal of experimental medicine
Croci DO,Salatino M,Rubinstein N,Cerliani JP,Cavallin LE,Leung HJ,Ouyang J,Ilarregui JM,Toscano MA,Domaica CI,Croci MC,Shipp MA,Mesri EA,Albini A,Rabinovich GA
14-4801 was used in Immunohistochemistry to provide novel opportunities not only for treating KS patients but also for understanding and managing a variety of solid tumors.
Mon Oct 22 00:00:00 UTC 2012
Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.
The Journal of experimental medicine
Boulard O,Kirchberger S,Royston DJ,Maloy KJ,Powrie FM
14-4801 was used in Flow cytometry/Cell sorting to investigate the genetic factors influencing the progression from Helicobacter hepaticus-driven colitis to tumorigenesis in a mouse model.
Mon Jul 02 00:00:00 UTC 2012
Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus.
Cancer research
Diaconu I,Cerullo V,Hirvinen ML,Escutenaire S,Ugolini M,Pesonen SK,Bramante S,Parviainen S,Kanerva A,Loskog AS,Eliopoulos AG,Pesonen S,Hemminki A
14-4801 was used in Immunohistochemistry to test whether a transcriptionally targeted oncolytic adenovirus, which features a capsid modification and is armed with CD40L, can result in oncolytic antitumor activity and stimulate an immune response.
Tue May 01 00:00:00 UTC 2012
TNF-α mediates macrophage-induced bystander effects through Netrin-1.
Cancer research
Yang Y,Wang X,Moore DR,Lightfoot SA,Huycke MM
14-4801 was used in Immunohistochemistry to define a pathway for macrophage-induced bystander effects in which TNF-a triggers TNFRSF1b receptor signaling, thus increasing production of Netrin-1.
Mon Oct 15 00:00:00 UTC 2012
Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages.
Journal of leukocyte biology
Movita D,Kreefft K,Biesta P,van Oudenaren A,Leenen PJ,Janssen HL,Boonstra A
14-4801 was used in Immunohistochemistry to observe that freshly isolated Kupffer cells are endocytic and show a relatively high basal ROS content.
Mon Oct 01 00:00:00 UTC 2012
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Bosmann M,Sarma JV,Atefi G,Zetoune FS,Ward PA
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that C5a alters the production of cytokines to regulate inflammatory functions.
Sun Apr 01 00:00:00 UTC 2012
Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice.
The American journal of pathology
Padmakumar VC,Speer K,Pal-Ghosh S,Masiuk KE,Ryscavage A,Dengler SL,Hwang S,Edwards JC,Coppola V,Tessarollo L,Stepp MA,Yuspa SH
14-4801 was used in Immunohistochemistry to elucidate the role of CLIC4 in the process of skin healing and corneal wound re-epithelialisation.
Sun Jul 01 00:00:00 UTC 2012
Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Koga T,Ichinose K,Mizui M,Crispín JC,Tsokos GC
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that calcium/calmodulin-dependent protein kinase IV plays a central role in development of autoimmunity in MRL/lpr mice.
Mon Oct 01 00:00:00 UTC 2012
Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.
Journal of immunology (Baltimore, Md. : 1950)
Su MA,Davini D,Cheng P,Giang K,Fan U,DeVoss JJ,Johannes KP,Taylor L,Shum AK,Valenzise M,Meloni A,Bour-Jordan H,Anderson MS
14-4801 was used in Immunohistochemistry to define how autoimune regulator (Aire) deficiency results in spontaneous autoimmune peripheral neuropathy in chronic inflammatory demyelinating polyneuropathy.
Tue May 15 00:00:00 UTC 2012
Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure.
Journal of cellular and molecular medicine
Huang HC,Haq O,Utsumi T,Sethasine S,Abraldes JG,Groszmann RJ,Iwakiri Y
14-4801 was used in Immunofluorescence to investigate the relationship between portal pressure and intestinal/plasma VEGF levels in different stages of cirrhosis using a rat model.
Tue May 01 00:00:00 UTC 2012
Evaluation of macrophage-specific promoters using lentiviral delivery in mice.
Gene therapy
Levin MC,Lidberg U,Jirholt P,Adiels M,Wramstedt A,Gustafsson K,Greaves DR,Li S,Fazio S,Linton MF,Olofsson SO,Borén J,Gjertsson I
14-4801 was used in Flow cytometry/Cell sorting to evaluate five different macrophage-specific promoters fused with green fluorescent protein to delineate the one with highest specificity using lentiviral delivery.
Thu Nov 01 00:00:00 UTC 2012
Radiation combined with thermal injury induces immature myeloid cells.
Shock (Augusta, Ga.)
Mendoza AE,Neely CJ,Charles AG,Kartchner LB,Brickey WJ,Khoury AL,Sempowski GD,Ting JP,Cairns BA,Maile R
14-4801 was used in Flow cytometry/Cell sorting to characterise the immune consequences of ionization radiation exposure combined with a full-thickness contact burn.
Thu Nov 01 00:00:00 UTC 2012
Differential expression of components of the retinoic acid signaling pathway in the adult mouse olfactory epithelium.
The Journal of comparative neurology
Peluso CE,Jang W,Dräger UC,Schwob JE
14-4801 was used in Flow cytometry/Cell sorting to study the expression of components of the retinoic acid signalling pathway in the adult mouse olfactory epithelium.
Thu Nov 01 00:00:00 UTC 2012
An intracameral injection of antigen induces in situ chemokines and cytokines required for the generation of circulating immunoregulatory monocytes.
PloS one
Pais R,Bhowmick S,Chattopadhyay S,Lemire Y,Sharafieh R,Yadav R,O'Rourke J,Cone RE
14-4801 was used in Flow cytometry/Cell sorting to further suggest that anterior chamber-associated immune deviation is initiated as the result of a mild proinflammatory response to intracameral injection.
Wed May 01 00:00:00 UTC 2013
Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs).
The Journal of biological chemistry
Yang W,Lu Y,Xu Y,Xu L,Zheng W,Wu Y,Li L,Shen P
14-4801 was used in Immunohistochemistry to identify that 17β-estradiol can suppress tumour growth via regulating the polarisation of macrophages.
Fri Nov 23 00:00:00 UTC 2012
Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury.
Nephron extra
Furuichi K,Kokubo S,Hara A,Imamura R,Wang Q,Kitajima S,Toyama T,Okumura T,Matsushima K,Suda T,Mukaida N,Kaneko S,Wada T
14-4801 was used in Immunohistochemistry to study the differential impact of Fas ligand and TNF-α upon apoptosis and inflammation in ischaemic acute kidney injury.
Sun Jan 01 00:00:00 UTC 2012
Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice.
PloS one
Haag LM,Fischer A,Otto B,Plickert R,Kühl AA,Göbel UB,Bereswill S,Heimesaat MM
14-4801 was used in Immunohistochemistry to investigate C. jejuni infection in healthy adult mice in which the microbiota was artificially modified by feeding live commensal E. coli.
Fri Sep 21 00:00:00 UTC 2012
An early reduction in Treg cells correlates with enhanced local inflammation in cutaneous leishmaniasis in CCR6-deficient mice.
PloS one
Barth T,Schmidt D,Botteron C,Nguyen TT,Ritter U,Männel DN,Lechner A
14-4801 was used in Flow cytometry/Cell sorting to analyse T cell subsets in the lymph nodes of CCR6-deficient mice over the course of Leishmania major infection.
Wed Mar 06 00:00:00 UTC 2013
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways.
Biochimica et biophysica acta
Marquardt JU,Seo D,Gómez-Quiroz LE,Uchida K,Gillen MC,Kitade M,Kaposi-Novak P,Conner EA,Factor VM,Thorgeirsson SS
14-4801 was used in Immunohistochemistry to demonstrate that deletion of c-Met receptor in hepatocytes results in pronounced changes in hepatic metabolism and microenvironment.
Fri Jun 01 00:00:00 UTC 2012
GM-CSF in the lung protects against lethal influenza infection.
American journal of respiratory and critical care medicine
Huang FF,Barnes PF,Feng Y,Donis R,Chroneos ZC,Idell S,Allen T,Perez DR,Whitsett JA,Dunussi-Joannopoulos K,Shams H
14-4801 was used in Flow cytometry/Cell sorting to determine if increased expression of granulocyte/macrophage colony-stimulating factor in the lung increases resistance to influenza.
Fri Jul 15 00:00:00 UTC 2011
A novel role for IL-22R1 as a driver of inflammation.
Blood
Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA
14-4801 was used in Flow cytometry/Cell sorting to document a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in ALK(+)ALCL.
Thu Jan 13 00:00:00 UTC 2011
Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
The Journal of clinical investigation
Nijagal A,Wegorzewska M,Jarvis E,Le T,Tang Q,MacKenzie TC
14-4801 was used in Flow cytometry/Cell sorting to investigate whether maternal cells trafficking into the fetus impose the barrier to effective in utero hematopoietic cell transplantation, showing that maternal T cells limit engraftment.
Tue Feb 01 00:00:00 UTC 2011
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.
The Journal of clinical investigation
Cheung R,Shen F,Phillips JH,McGeachy MJ,Cua DJ,Heyworth PG,Pierce RH
14-4801 was used in Flow cytometry/Cell sorting to identify the MDL-1/Syk/PI3K/Akt/eNOS pathway as a potential new target for the prevention of the progression of SIRS to shock.
Tue Nov 01 00:00:00 UTC 2011
Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
The Journal of experimental medicine
Wei J,Loke P,Zang X,Allison JP
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of B7x in maintaining peripheral tolerance and protecting from CD4 T cell-mediated autoimmunity.
Mon Aug 01 00:00:00 UTC 2011
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
14-4801 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 UTC 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-4801 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 UTC 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-4801 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 UTC 2011
E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.
The Journal of experimental medicine
Hatchi E,Rodier G,Lacroix M,Caramel J,Kirsh O,Jacquet C,Schrepfer E,Lagarrigue S,Linares LK,Lledo G,Tondeur S,Dubus P,Sardet C,Le Cam L
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to reveal a role for E4F1 in the survival of myeloid leukemic cells.
Mon Jul 04 00:00:00 UTC 2011
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
The Journal of experimental medicine
Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ
14-4801 was used in Flow cytometry/Cell sorting to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.
Mon Mar 14 00:00:00 UTC 2011
Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy.
Biomaterials
Kwong B,Liu H,Irvine DJ
14-4801 was used in Flow cytometry/Cell sorting to investigate whether systemic exposure to immuno-agonist compounds could be limited to local tumour tissue, showing that liposome-anchored combinatorial immunotherapy could induce potent anti-tumor response.
Mon Aug 01 00:00:00 UTC 2011
Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth.
Cancer research
Schmid MC,Avraamides CJ,Foubert P,Shaked Y,Kang SW,Kerbel RS,Varner JA
14-4801 was used in Immunohistochemistry to show that stromal cell-derived growth factor 1 alpha and interleukin 1 beta collaborate with myeloid cell integrin-α4β1 to promote tumor inflammation and growth.
Tue Nov 15 00:00:00 UTC 2011
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.
Diabetes
Thayer TC,Delano M,Liu C,Chen J,Padgett LE,Tse HM,Annamali M,Piganelli JD,Moldawer LL,Mathews CE
14-4801 was used in Flow cytometry/Cell sorting to determine the cellular sources of ROS that are necessary for type 1 diabetes initiation, showing that superoxide production by macrophages and T cells is critical.
Mon Aug 01 00:00:00 UTC 2011
CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection.
PLoS pathogens
Fischer MA,Davies ML,Reider IE,Heipertz EL,Epler MR,Sei JJ,Ingersoll MA,Rooijen NV,Randolph GJ,Norbury CC
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus.
Tue Nov 01 00:00:00 UTC 2011
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice.
PLoS pathogens
Seo SU,Kwon HJ,Ko HJ,Byun YH,Seong BL,Uematsu S,Akira S,Kweon MN
14-4801 was used in Flow cytometry/Cell sorting to suggest that IFN-I contributes to resistance of influenza infection by control of monocytes and neutrophils in the lung.
Tue Feb 01 00:00:00 UTC 2011
Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration.
Development (Cambridge, England)
Murphy MM,Lawson JA,Mathew SJ,Hutcheson DA,Kardon G
14-4801 was used in Immunofluorescence to elucidate the roles of cells involved in muscular regeneration.
Thu Sep 01 00:00:00 UTC 2011
Connective tissue fibroblasts and Tcf4 regulate myogenesis.
Development (Cambridge, England)
Mathew SJ,Hansen JM,Merrell AJ,Murphy MM,Lawson JA,Hutcheson DA,Hansen MS,Angus-Hill M,Kardon G
14-4801 was used in Immunocytochemistry-immunoflourescence to show that the transcription factor Tcf4 is strongly expressed in connective tissue fibroblasts and that Tcf4(GFPCre) mice allow genetic manipulation of these fibroblasts.
Sat Jan 01 00:00:00 UTC 2011
Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus.
Clinical and experimental immunology
Chen S,Akbar SM,Abe M,Hiasa Y,Onji M
14-4801 was used in Flow cytometry/Cell sorting to localise and assess functions of hepatic myeloid-derived suppressor cells in a normal liver and in a murine model of chronic hepatitis B virus infection.
Sat Oct 01 00:00:00 UTC 2011
High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response.
Laboratory investigation; a journal of technical methods and pathology
Duan L,Wang CY,Chen J,Gong Q,Zhu P,Zheng F,Tan Z,Gong F,Fang M
14-4801 was used in Immunohistochemistry to investigate the role of HMGB1 in cadiac allograft acute rejection, showing that it promotes rejection by enhancing IL-6-dependent Th17 alloreactive response.
Sat Jan 01 00:00:00 UTC 2011
Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis.
Journal of immunology (Baltimore, Md. : 1950)
Meyer-Schwesinger C,Dehde S,Klug P,Becker JU,Mathey S,Arefi K,Balabanov S,Venz S,Endlich KH,Pekna M,Gessner JE,Thaiss F,Meyer TN
14-4801 was used in Immunohistochemistry to establish a reproducible model of immune-mediated podocyte injury in mice with subepithelial immune complex formation.
Thu Sep 15 00:00:00 UTC 2011
Differential expression of NLRP3 among hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950)
Guarda G,Zenger M,Yazdi AS,Schroder K,Ferrero I,Menu P,Tardivel A,Mattmann C,Tschopp J
14-4801 was used in Flow cytometry/Cell sorting to characterize NOD-like receptor pyrin domain 3 (NLRP3) expression due to importance in health and disease.
Tue Feb 15 00:00:00 UTC 2011
Hepatic stellate cells function as regulatory bystanders.
Journal of immunology (Baltimore, Md. : 1950)
Ichikawa S,Mucida D,Tyznik AJ,Kronenberg M,Cheroutre H
14-4801 was used in Flow cytometry/Cell sorting to suggest that HSC can function as regulatory bystanders, and therefore, by promoting Tregs and suppressing Th17 differentiation, they might represent key players in the mechanism that drives liver-induced tolerance.
Sun May 15 00:00:00 UTC 2011
Prophylactic application of bovine colostrum ameliorates murine colitis via induction of immunoregulatory cells.
The Journal of nutrition
Bodammer P,Maletzki C,Waitz G,Emmrich J
14-4801 was used in Immunohistochemistry to address the question whether bovine colostrum, the first milk produced by mammals, is able to prevent dextran sulfate sodium (DSS)-induced colitis in mice.
Wed Jun 01 00:00:00 UTC 2011
A dense network of dendritic cells populates the murine epididymis.
Reproduction (Cambridge, England)
Da Silva N,Cortez-Retamozo V,Reinecker HC,Wildgruber M,Hill E,Brown D,Swirski FK,Pittet MJ,Breton S
14-4801 was used in Immunofluorescence in immunohistochemistry on frozen tissues to identify a dense population of dendritic cells populating the base of the murine epididymal epithelium.
Sun May 01 00:00:00 UTC 2011
IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanisms.
PloS one
Tse BW,Russell PJ,Lochner M,Förster I,Power CA
14-4801 was used in Immunohistochemistry to indicate that local IL-18 in the tumor environment can significantly potentiate anti-tumor immunity in the prostate.
Tue Feb 28 00:00:00 UTC 2012
Selective gelatinase blockage ameliorates acute DSS colitis.
European journal of microbiology & immunology
Heimesaat MM,Dunay IR,Fuchs D,Trautmann D,Fischer A,Kühl AA,Loddenkemper C,Batra A,Siegmund B,Krell HW,Bereswill S,Liesenfeld O
14-4801 was used in Immunohistochemistry-immunofluorescence to investigate the potential beneficial effects exerted by doxycycline nonselectively blocking matrix metalloproteinases and RO28-2653 in acute DSS colitis.
Thu Sep 01 00:00:00 UTC 2011
Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice.
PloS one
Juncker-Jensen A,Lund LR
14-4801 was used in Immunohistochemistry to demonstrate a phenotypic overlap between MMP-13 and the plasminogen activation system in the process of wound healing.
Fri Feb 04 00:00:00 UTC 2011
The distinct roles of MMP-2 and MMP-9 in acute DSS colitis.
European journal of microbiology & immunology
Heimesaat MM,Dunay IR,Fuchs D,Trautmann D,Fischer A,Kühl AA,Loddenkemper C,Siegmund B,Batra A,Bereswill S,Liesenfeld O
14-4801 was used in Immunohistochemistry to investigate whether geltinase A or B expression is pivotal in mediating large intestinal inflammation.
Thu Dec 01 00:00:00 UTC 2011
Impact of a probiotic fermented milk in the gut ecosystem and in the systemic immunity using a non-severe protein-energy-malnutrition model in mice.
BMC gastroenterology
Maldonado Galdeano C,Novotny Núñez I,de Moreno de LeBlanc A,Carmuega E,Weill R,Perdigón G
14-4801 was used in Immunofluorescence to evaluate the effects of a probiotic fermented milk as a complement of a re-nutrition diet and for its protection against Salmonella.
Thu May 26 00:00:00 UTC 2011
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.
Cancer cell
Takahashi H,Ogata H,Nishigaki R,Broide DH,Karin M
14-4801 was used in Immunohistochemistry to determine whether tobacco smoke acts as a tumor promoter once malignant initiation, such as caused by K-ras activation, has taken place.
Tue Jan 19 00:00:00 UTC 2010
Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia.
Gastroenterology
Shibata W,Takaishi S,Muthupalani S,Pritchard DM,Whary MT,Rogers AB,Fox JG,Betz KS,Kaestner KH,Karin M,Wang TC
14-4801 was used in Immunohistochemistry to demonstrate that loss of IKKbeta/NF-kappaB signaling in GECs results in increased apoptosis and necrosis in response to cellular stress.
Mon Mar 01 00:00:00 UTC 2010
Plasma cells negatively regulate the follicular helper T cell program.
Nature immunology
Pelletier N,McHeyzer-Williams LJ,Wong KA,Urich E,Fazilleau N,McHeyzer-Williams MG
14-4801 was used in Flow cytometry/Cell sorting to study plasma cells, showing that they negatively regulate the follicular helper T cell program.
Wed Dec 01 00:00:00 UTC 2010
The sympathetic nervous system induces a metastatic switch in primary breast cancer.
Cancer research
Sloan EK,Priceman SJ,Cox BF,Yu S,Pimentel MA,Tangkanangnukul V,Arevalo JM,Morizono K,Karanikolas BD,Wu L,Sood AK,Cole SW
14-4801 was used in Immunohistochemistry-immunofluorescence to identify activation of the sympathetic nervous system as a novel neural regulator of breast cancer metastasis.
Wed Sep 15 00:00:00 UTC 2010
Intravital imaging of IL-1beta production in skin.
The Journal of investigative dermatology
Matsushima H,Ogawa Y,Miyazaki T,Tanaka H,Nishibu A,Takashima A
14-4801 was used in Flow cytometry/Cell sorting to represent a useful tool for studying spatial regulation of IL-1beta production in skin.
Tue Jun 01 00:00:00 UTC 2010
UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
PLoS pathogens
Melo MB,Kasperkovitz P,Cerny A,Könen-Waisman S,Kurt-Jones EA,Lien E,Beutler B,Howard JC,Golenbock DT,Gazzinelli RT
14-4801 was used in Functional assays to reveal a critical role for UNC93B1 on induction of IL-12/IFNγ production and autonomous control of Toxoplasma replication by macrophages.
Thu Aug 26 00:00:00 UTC 2010
Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast.
Journal of leukocyte biology
Lin JS,Huang JH,Hung LY,Wu SY,Wu-Hsieh BA
14-4801 was used in Flow cytometry/Cell sorting to delineate the distinct roles of CR3, Dectin-1, and sialic acids in the interaction with Histoplasma.
Thu Jul 01 00:00:00 UTC 2010
Enoxaparin improves the course of dextran sodium sulfate-induced colitis in syndecan-1-deficient mice.
The American journal of pathology
Floer M,Götte M,Wild MK,Heidemann J,Gassar ES,Domschke W,Kiesel L,Luegering A,Kucharzik T
14-4801 was used in Immunohistochemistry to investigate the role of Sdc1 in murine dextran sodium sulfate (DSS)-induced colitis.
Fri Jan 01 00:00:00 UTC 2010
IL-33 exacerbates eosinophil-mediated airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Stolarski B,Kurowska-Stolarska M,Kewin P,Xu D,Liew FY
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that the IL-33/ST2 signaling pathway activates airway eosinophils that exacerbate airway inflammation in an autocrine and paracrine manner.
Wed Sep 15 00:00:00 UTC 2010
Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.
Journal of immunology (Baltimore, Md. : 1950)
Henry T,Kirimanjeswara GS,Ruby T,Jones JW,Peng K,Perret M,Ho L,Sauer JD,Iwakura Y,Metzger DW,Monack DM
14-4801 was used in Flow cytometry/Cell sorting to determine that type I IFN signalling might contribute to the resistance of mice to infection with other intracellular bacteria.
Thu Apr 01 00:00:00 UTC 2010
IL-33 induces IL-13-dependent cutaneous fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Rankin AL,Mumm JB,Murphy E,Turner S,Yu N,McClanahan TK,Bourne PA,Pierce RH,Kastelein R,Pflanz S
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to identify IL-33 as a previously unrecognized profibrotic mediator in skin and highlight the cellular and molecular pathways by which this pathology develops.
Mon Feb 01 00:00:00 UTC 2010
CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Leichtle A,Hernandez M,Ebmeyer J,Yamasaki K,Lai Y,Radek K,Choung YH,Euteneuer S,Pak K,Gallo R,Wasserman SI,Ryan AF
14-4801 was used in Immunohistochemistry to show that, in the absence of TNF, Otitis media is prolonged after middle ear infection with nontypeable Haemophilus influenzae.
Mon Mar 15 00:00:00 UTC 2010
Role of Cdk4 in lymphocyte function and allergen response.
Cell cycle (Georgetown, Tex.)
Chow YH,Zhu XD,Liu L,Schwartz BR,Huang XZ,Harlan JM,Schnapp LM
14-4801 was used in Flow cytometry/Cell sorting to characterise the development and function of hematopoietic cells in Cdk4(-/-) mice and to assess the response of Cdk4(-/-) mice to allergen challenge.
Wed Dec 15 00:00:00 UTC 2010
Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair.
Molecular and cellular biology
Ren X,Zhang Y,Snyder J,Cross ER,Shah TA,Kalin TV,Kalinichenko VV
14-4801 was used in Flow cytometry/Cell sorting to study how Foxm1 is critical for liver repair and is required for the recruitment of monocytes to the injured liver.
Mon Nov 01 00:00:00 UTC 2010
Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction.
Human gene therapy
Fan X,Lang H,Zhou X,Zhang L,Yin R,Maciejko J,Giannitsos V,Motyka B,Medin JA,Platt JL,West LJ
14-4801 was used in Immunohistochemistry to determine the feasibility of developing a murine model of the ABO histo-blood group system.
Thu Jul 01 00:00:00 UTC 2010
Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation.
Infection and immunity
Guerrero A,Jain N,Wang X,Fries BC
14-4801 was used in Flow cytometry/Cell sorting to investigate the interaction between macrophages and cells from smooth-colony or mucoid-colony variants arising from phenotypic switching of Cryptococcus neoformans.
Mon Mar 01 00:00:00 UTC 2010
Hematopoietic proliferative lesions in the spleen of rasH2 transgenic mice treated with MNU.
Toxicologic pathology
Long GG,Goodman DG,Credille KM,Mann PC,Wilson JM,Cardy R
14-4801 was used in Immunohistochemistry to study the development of haematopoietic proliferative lesions in the spleen of rasH2 transgenic mice treated with N-methyl-N-nitrosurea.
Wed Dec 01 00:00:00 UTC 2010
Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein.
PloS one
Jiang D,Schwarz H
14-4801 was used in Flow cytometry/Cell sorting to confirm the role of CD137 ligand signalling in regulating myelopoiesis, and demonstrate that this growth promoting influence is restricted to the monocytic lineage.
Mon Dec 13 00:00:00 UTC 2010
Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis.
Circulation research
Li K,Xu W,Guo Q,Jiang Z,Wang P,Yue Y,Xiong S
14-4801 was used in Magnetic cell separation to facilitate the understanding of the mechanism underlying gender bias in susceptibility to CVB3 myocarditis and the development of therapeutic strategies based on macrophage polarization for inflammatory heart disease.
Fri Aug 14 00:00:00 UTC 2009
Mice that overexpress human heat shock protein 27 have increased renal injury following ischemia reperfusion.
Kidney international
Chen SW,Kim M,Kim M,Song JH,Park SW,Wells D,Brown K,Belleroche Jd,D'Agati VD,Lee HT
14-4801 was used in Flow cytometry/Cell sorting to investigate increased renal injury in mice that overexpress human heat shock protein 27 following ischemia reperfusion.
Sun Mar 01 00:00:00 UTC 2009
Indirect action of tumor necrosis factor-alpha in liver injury during the CD8+ T cell response to an adeno-associated virus vector in mice.
Hepatology (Baltimore, Md.)
Giannandrea M,Pierce RH,Crispe IN
14-4801 was used in Immunohistochemistry to develop a new model of CD8+ T-cell-mediated hepatitis based upon an adeno-associated virus-based gene therapy vector.
Mon Jun 01 00:00:00 UTC 2009
CCR2 promotes hepatic fibrosis in mice.
Hepatology (Baltimore, Md.)
Seki E,de Minicis S,Inokuchi S,Taura K,Miyai K,van Rooijen N,Schwabe RF,Brenner DA
14-4801 was used in Immunohistochemistry to show that CCR2 promotes hepatic stellate cell chemotaxis and the development of hepatic fibrosis.
Wed Jul 01 00:00:00 UTC 2009
Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ.
Cancer research
Fleming NI,Trivett MK,George J,Slavin JL,Murray WK,Moseley JM,Anderson RL,Thomas DM
14-4801 was used in Immunohistochemistry to demonstrate that loss of PTHrP accelerates mammary tumorigenesis possibly by a non-cell-autonomous tumor suppressor pathway.
Tue Sep 15 00:00:00 UTC 2009
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
The Journal of investigative dermatology
Sadri N,Schneider RJ
14-4801 was used in Flow cytometry/Cell sorting to highlight HNRNPD and mRNA stability as important for the processes of leukocyte recruitment and inflammatory activation within the skin.
Sun Mar 01 00:00:00 UTC 2009
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.
PLoS pathogens
Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M
14-4801 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.
Wed Apr 01 00:00:00 UTC 2009
Role of nitric oxide in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.
Journal of virology
Lee YS,Li N,Shin S,Jun HS
14-4801 was used in Immunohistochemistry to show that NO plays an important role in the activation of macrophages and apoptosis of pancreatic β cells in EMC-D virus-infected mice.
Sat Aug 01 00:00:00 UTC 2009
SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages.
The American journal of pathology
Kirby AC,Beattie L,Maroof A,van Rooijen N,Kaye PM
14-4801 was used in Flow cytometry/Cell sorting to show the protective activity of SIGNR1(+) marginal zone macrophages can be compensated for by activated red pulp macrophages.
Tue Sep 01 00:00:00 UTC 2009
Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression.
Journal of immunology (Baltimore, Md. : 1950)
Wu C,Rauch U,Korpos E,Song J,Loser K,Crocker PR,Sorokin LM
14-4801 was used in Flow cytometry/Cell sorting to propose a new direct cell-cell interaction-based mechanism regulating the expansion of Tregs during autoimmune and inflammatory processes.
Fri May 15 00:00:00 UTC 2009
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.
American journal of physiology. Gastrointestinal and liver physiology
Onizawa M,Nagaishi T,Kanai T,Nagano K,Oshima S,Nemoto Y,Yoshioka A,Totsuka T,Okamoto R,Nakamura T,Sakamoto N,Tsuchiya K,Aoki K,Ohya K,Yagita H,Watanabe M
14-4801 was used in Immunohistochemistry to suggest that TNFR2 signaling in intestinal epithelial cells may be involved in development of colitis-associated cancer.
Wed Apr 01 00:00:00 UTC 2009
Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.
American journal of physiology. Renal physiology
Meyer-Schwesinger C,Dehde S,von Ruffer C,Gatzemeier S,Klug P,Wenzel UO,Stahl RA,Thaiss F,Meyer TN
14-4801 was used in Immunohistochemistry to investigate how Rho kinase inhibition by preventive or therapeutic treatment effectively reduced endotoxic kidney injury in part by attenuation of NF-kappaB p65 activation.
Fri May 01 00:00:00 UTC 2009
Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation.
Arthritis and rheumatism
Kadl A,Galkina E,Leitinger N
14-4801 was used in Immunohistochemistry to demonstrate that oxidized phospholipids trigger an inflammatory response, causing selective macrophage accumulation enabling the pathogenesis of chronic inflammatory rheumatic diseases.
Fri May 01 00:00:00 UTC 2009
Malarial hemozoin is a Nalp3 inflammasome activating danger signal.
PloS one
Dostert C,Guarda G,Romero JF,Menu P,Gross O,Tardivel A,Suva ML,Stehle JC,Kopf M,Stamenkovic I,Corradin G,Tschopp J
14-4801 was used in Flow cytometry/Cell sorting to hypothesized that hemozoin could activate the Nalp3 inflammasome.
Tue Aug 04 00:00:00 UTC 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-4801-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-4801-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 UTC 2008
The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease.
The Journal of experimental medicine
Carlson T,Kroenke M,Rao P,Lane TE,Segal B
14-4801 was used in Flow cytometry/Cell sorting to demonstrate that ELR(+) CXC chemokines and CXCR2-expressing polymorphonuclear leukocytes are required for the development of experimental autoimmune encephalomyelitis.
Mon Apr 14 00:00:00 UTC 2008
Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha.
Clinical cancer research : an official journal of the American Association for Cancer Research
Shiraishi K,Ishiwata Y,Nakagawa K,Yokochi S,Taruki C,Akuta T,Ohtomo K,Matsushima K,Tamatani T,Kanegasaki S
14-4801-82 was used in Immunohistochemistry (Frozen) to study whether intravenous administration of a chemokine after local tumour site irradiation can prevent remaining, as well as distant, non-irradiated tumour cell growth by leukocyte recruitment.
Fri Feb 15 00:00:00 UTC 2008
Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha.
Clinical cancer research : an official journal of the American Association for Cancer Research
Shiraishi K,Ishiwata Y,Nakagawa K,Yokochi S,Taruki C,Akuta T,Ohtomo K,Matsushima K,Tamatani T,Kanegasaki S
14-4801-82 was used in Immunohistochemistry (Frozen) to study whether intravenous administration of a chemokine after local tumour site irradiation can prevent remaining, as well as distant, non-irradiated tumour cell growth by leukocyte recruitment.
Fri Feb 15 00:00:00 UTC 2008
Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology
Bonderman D,Jakowitsch J,Redwan B,Bergmeister H,Renner MK,Panzenböck H,Adlbrecht C,Georgopoulos A,Klepetko W,Kneussl M,Lang IM
Tue Apr 01 00:00:00 UTC 2008
Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology
Bonderman D,Jakowitsch J,Redwan B,Bergmeister H,Renner MK,Panzenböck H,Adlbrecht C,Georgopoulos A,Klepetko W,Kneussl M,Lang IM
Tue Apr 01 00:00:00 UTC 2008
Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis.
Clinical immunology (Orlando, Fla.)
Kuerten S,Javeri S,Tary-Lehmann M,Lehmann PV,Angelov DN
14-4801 was used in Immunohistochemistry to investigate the histopathological differences between two mouse models of experimental autoimmune encephalomyelitis.
Sat Nov 01 00:00:00 UTC 2008
Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol.
Journal of leukocyte biology
Springs AE,Karmaus PW,Crawford RB,Kaplan BL,Kaminski NE
14-4801 was used in Immunofluorescence to demonstrate differential involvement of CB1 and/or CB2 in immune modulation by Delta9-THC and in some control responses.
Mon Dec 01 00:00:00 UTC 2008
Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury.
Journal of immunology (Baltimore, Md. : 1950)
Furuichi K,Gao JL,Horuk R,Wada T,Kaneko S,Murphy PM
14-4801 was used in Immunohistochemistry to suggest that CCR1 regulates trafficking of macrophages and neutrophils to kidney following renal ischemia-reperfusion injury.
Mon Dec 15 00:00:00 UTC 2008
Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury.
Journal of immunology (Baltimore, Md. : 1950)
Furuichi K,Gao JL,Horuk R,Wada T,Kaneko S,Murphy PM
14-4801 was used in Immunohistochemistry to suggest that CCR1 regulates trafficking of macrophages and neutrophils to kidney following renal ischemia-reperfusion injury.
Mon Dec 15 00:00:00 UTC 2008
Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice.
Gene therapy
Westwood JA,Murray WK,Trivett M,Shin A,Neeson P,MacGregor DP,Haynes NM,Trapani JA,Mayura-Guru P,Fox S,Peinert S,Honemann D,Prince HM,Ritchie D,Scott AM,Smyth FE,Smyth MJ,Darcy PK,Kershaw MH
14-4801 was used in Immunohistochemistry on frozen tissues to indicate that the use of retroviral vectors to transduce T cells does not lead to malignant transformation.
Tue Jul 01 00:00:00 UTC 2008
Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.
International archives of allergy and immunology
Muralimohan G,Rossi RJ,Vella AT
14-4801 was used in Flow cytometry/Cell sorting to investigate how staphylococcal enterotoxins regulate innate immune cells, showing that it leads to rapid accumulation of CD11c+ cells in the lung following superantigen challenge.
Tue Sep 09 00:00:00 UTC 2008
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
PloS one
Banerjee R,Mosley RL,Reynolds AD,Dhar A,Jackson-Lewis V,Gordon PH,Przedborski S,Gendelman HE
14-4801 was used in Immunohistochemistry on frozen tissues to investigate the role of T cell immunity in human G93A SOD1 Tg mice and in ALS patients.
Wed Jul 23 00:00:00 UTC 2008
Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections.
Blood
Nakano N,Nishiyama C,Kanada S,Niwa Y,Shimokawa N,Ushio H,Nishiyama M,Okumura K,Ogawa H
14-4801 was used in Immunofluorescence to demonstrate that mast cells are a crucial source of functional IL-12.
Fri Jun 01 00:00:00 UTC 2007
CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules.
Journal of leukocyte biology
Ueha S,Yoneyama H,Hontsu S,Kurachi M,Kitabatake M,Abe J,Yoshie O,Shibayama S,Sugiyama T,Matsushima K
14-4801 was used in Flow cytometry/Cell sorting to provide the evidence that CCR7 mediates nTreg migration to the paracortical areas of lymph nodes under steady-state conditions, but also takes place in the medulla.
Thu Nov 01 00:00:00 UTC 2007
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.
The Journal of biological chemistry
Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M
14-4801 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.
Fri Nov 16 00:00:00 UTC 2007
Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.
Gastroenterology
Chinen T,Kobayashi T,Ogata H,Takaesu G,Takaki H,Hashimoto M,Yagita H,Nawata H,Yoshimura A
14-4801 was used in Immunohistochemistry on paraffin embedded tissues to discover the suppressor of cytokine signalling-1 plays an important role in preventing murine colitis by restricting the cytokine signals.
Wed Feb 01 00:00:00 UTC 2006
Chemokine receptor CX3CR1 regulates renal interstitial fibrosis after ischemia-reperfusion injury.
The American journal of pathology
Furuichi K,Gao JL,Murphy PM
14-4801 was used in Immunohistochemistry to demonstrate that the fractalkine receptor CX3CR1 is able to reduce inflammation and fibrosis after ischemia-reperfusion injury in mice.
Tue Aug 01 00:00:00 UTC 2006
Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kim YS,Kim SS,Cho JJ,Choi DH,Hwang O,Shin DH,Chun HS,Beal MF,Joh TH
14-4801 was used in Immunocytochemistry to suggest that the distinctive signal of neuronal apoptosis is the release of active form of matrix metalloproteinase-3 that activates microglia.
Wed Apr 06 00:00:00 UTC 2005
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
Journal of leukocyte biology
Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ
Sat Oct 01 00:00:00 UTC 2005
