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Immunogen sequence: ASKYLAKGTNI YVPSSYHLPK EMKSLKKKHR SPERRKSLFI HENNEKNDRD RGKTNADSKK QTTVAEADIF NNSSRSLS
Highest antigen sequence identity to the following orthologs - mouse 71%, rat 71%.
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: family with sequence similarity 178, member A; protein FAM178A; SMC5-SMC6 complex localization factor protein 2; Smc5/6 localization factor 1
Gene Aliases: C10orf6; FAM178A; SLF2
UniProt ID: (Human) Q8IX21
Entrez Gene ID: (Human) 55719
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