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The Fanconi anemia complementation group currently includes FANCA, FANCB, FANCC, FANCD1 , FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ , FANCL, FANCM and FANCN . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F.
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蛋白别名: Fanconi anemia group F protein; Fanconi anemia, complementation group F; MGC126856; Protein FACF
基因别名: A730016A17; FAF; FANCF; RGD1561456
UniProt ID: (Human) Q9NPI8, (Mouse) E9Q5Z5
Entrez Gene ID: (Human) 2188, (Rat) 499155, (Mouse) 100040608