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Immunogen sequence: SHAILEALAA PDRAPFALLA LRCACPEDAR ASPLPNEAWV ALRRRHPGLA VELELEPALP AESVTRVLQP AVPVAALRLN LSGDTVGPVR FAAHHYAATL
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 79%.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: F-box and leucine-rich repeat protein 8; F-box protein FBL8; F-box/LRR-repeat protein 8
Gene Aliases: FBL8; FBXL8; RGD1566420
UniProt ID: (Human) Q96CD0, (Mouse) Q8CIG9
Entrez Gene ID: (Human) 55336, (Mouse) 50788, (Rat) 498941
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