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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: F-box only protein 21
Gene Aliases: 2810425J22Rik; AU016673; FBX21; FBXO21; KIAA0875; mKIAA0875
UniProt ID: (Human) O94952, (Mouse) Q8VDH1
Entrez Gene ID: (Dog) 486290, (Human) 23014, (Mouse) 231670
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