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Invitrogen

FBXW11 Polyclonal Antibody

View all (10) FBXW11 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (5)

Application

FBXW11 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

FBXW11 Antibody (PA5-109715) in ICC/IF

Immunofluorescence analysis of FBXW11 in NIH/3T3 cells. Samples were incubated with FBXW11 Polyclonal antibody (Product # PA5-109715) using a dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.

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Product Details

PA5-109715

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

Immunocytochemistry (ICC/IF)

1:50-1:200

ELISA (ELISA)

1 µg/mL

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 443-542 of human FBXW11 (NP_0364322)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

2.75 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2855126

Product Specific Information

Immunogen sequence: FLNVPPSAQN ETRS

Target Information

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: beta-transducin repeat-containing protein 2; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS

Gene Aliases: BTRC2; BTRCP2; Fbw11; FBW1B; FBXW11; FBXW1B; Hos; KIAA0696

UniProt ID: (Human) Q9UKB1

Entrez Gene ID: (Human) 23291

Function(s)

ubiquitin-protein transferase activity protein binding protein dimerization activity ubiquitin protein ligase activity

Process(es)

G2/M transition of mitotic cell cycle protein polyubiquitination stimulatory C-type lectin receptor signaling pathway protein dephosphorylation Wnt signaling pathway protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein destabilization NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway negative regulation of NF-kappaB import into nucleus positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated rhythmic process T cell receptor signaling pathway stress-activated MAPK cascade

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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