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Immunogen sequence: PLHRLTMMIK DKQQVKKSYI GVHQQIEAEM IKVTKTELEK LKCSYRQLIK EMNSAKEKYK EALAKGKETE KAKERYDKAT MKLHMLHNQY VLALKGAQLH QNQYYDITLP LLLDSLQKMQ EEMIKALKGI FDEYSQITSL VTEEIVNVHK EIQMSVEQID PSTEYNNFID VHRTTAAKEQ EIEFDTSLLE ENENLQANEI MWNNLTAESL QVMLKTLAEE LMQTQQMLLN KEEAVLELEK RIEESSETCE KKSDIVLLLS QKQALEELKQ SVQQLRCTEA KFSAQKELLE QKVQENDGKE PPPVVNYEED ARSVTSMERK ERLSKFESIR HSIAGIIRSP KSALGSSALS
FER is a member of the FPS/FES family of non-receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes. The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.10.2; Feline encephalitis virus-related kinase FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p94-Fer; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; Proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase Fer; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Aliases: AV082135; C330004K01Rik; FER; Fert; Fert2; p94-Fer; PPP1R74; TYK3
UniProt ID: (Human) P16591, (Mouse) P70451
Entrez Gene ID: (Human) 2241, (Mouse) 14158
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