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Invitrogen
FHL1 Polyclonal Antibody
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FIGURE: 1 / 1
FHL1 Antibody (PA5-96331) in WB
Western blot analysis of FHL1 in extracts of various cell lines. Samples were incubated with FHL1 Polyclonal antibody (Product # PA5-96331) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96331
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 27-296 of human FHL1 (NP_0011531711)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
27 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RDPLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD SKEVHYKNRF WHDTCFRCAK CLHPLANETF VAKDNKILCN KCTTREDSPK CKGCFKAIVA GDQNVEYKGT VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHADCFVCVT CSKKLAGQRF TAVEDQYYCV DCYKNFVAKK CAGCKNPITG FGKGSSVVAY EGQSWHDYCF HCKKCSVNLA NKRFVFHQEQ VYCPDCAKKL; Positive Samples: U-251MG, 22Rv1, MCF7, Mouse kidney; Cellular Location: Cytoplasm, Nucleus, cytosol
Target Information
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA535K18.1; FHL-1; FHL1; FHL1B; formerly SLIM1; Four and a half LIM domains protein 1; four-and-a-half Lin11, Isl-1 and Mec-3 domains 1; heart protein with four and a half LIM domains; KYO-T; KyoT; LIM protein SLIMMER; MGC111107; RAM14-1; RBP-associated molecule 14-1; RP11-535K18.1; skeletal and cardiac muscle SLIM isoform; Skeletal muscle LIM-protein 1; SLIM; unnamed protein product
Gene Aliases: FCMSU; FHL-1; FHL1; FHL1A; FHL1B; FLH1A; KYOT; RAM14-1; RBMX1A; RBMX1B; SLIM; SLIM-1; SLIM1; SLIMMER; XMPMA
UniProt ID: (Human) Q13642, (Mouse) P97447
Entrez Gene ID: (Human) 2273, (Mouse) 14199
muscle organ development
organ morphogenesis
negative regulation of G2/M transition of mitotic cell cycle
cell differentiation
negative regulation of cell growth
regulation of atrial cardiac muscle cell membrane depolarization
positive regulation of potassium ion transmembrane transport
negative regulation of G1/S transition of mitotic cell cycle
regulation of membrane depolarization
multicellular organism development
positive regulation of potassium ion transport
regulation of potassium ion transmembrane transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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