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Immunogen sequence: DNEPPDYKSL IPLERAVING QLYEESENQD EDPNDEGSVL SFKCSQSTPC PVNRKLWIPW MKSKEGHLQN GKMQTKPNAN FVQPGDLVLS HTPGQP
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.
Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 130 kDa GPBP-interacting protein; 90 kDa GPBP-interacting protein; DOC-1; downregulated in ovarian cancer 1-like; filamin A interacting protein 1-like; Filamin A-interacting protein 1-like; GIP130a; GIP130b; GIP130c; Protein down-regulated in ovarian cancer 1; protein down-regulated in ovarian cancer 1 homolog
Gene Aliases: 4631422O05Rik; COL4A3BPIP; DOC-1; DOC1; FILIP1L; GIP130; GIP90
UniProt ID: (Human) Q4L180
Entrez Gene ID: (Human) 11259, (Mouse) 78749
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