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Invitrogen
FK506 Monoclonal Antibody (FK1)
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Product Details
MA1-90186
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
FK1
Immunogen
Conjugate FK-506-BSA.
Conjugate
Unconjugated
Form
Liquid
Concentration
4.5 mg/mL
Purification
Euglobulin precipitation, Size-exclusion - Dialysis
Storage buffer
TBS, pH 8.0
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1958006
Product Specific Information
This antibody recognizes conjugated and non-conjugated FK-506 with apparent dissociation constant Kd=10^9M.
Target Information
Tacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [National Center for Biotechnology Information. PubChem Compound Database; CID=445643].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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