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FKBP5 Polyclonal Antibody

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Antibody Testing Data (8)

FKBP5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

FKBP5 Antibody (14155-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 14155-1-AP (FKBP5 antibody) at dilution of 1:50 (under 40x lens).

FKBP5 Antibody in Immunoprecipitation (IP)

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Product Details

14155-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FKBP5 Fusion Protein Ag5337 (1-375 aa encoded by BC042605)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTTDEGAKN NEESPTATVA EQGEDITSKK DRGVLKIVKR VGNGEETPMI GDKVYVHYKG KLSNGKKFDS SHDRNEPFVF SLGKGQVIKA WDIGVATMKK GEICHLLCKP EYAYGSAGSL PKIPSNATLF FEIELLDFKG EDLFEDGGII RRTKRKGEGY SNPNEGATVE IHLEGRCGGR MFDCRDVAFT VGEGEDHDIP IGIDKALEKM QREEQCILYL GPRYGFGEAG KPKFGIEPNA ELIYEVTLKS FEKAKESWEM DTKEKLEQAA IVKEKGTVYF KGGKYMQAVI QYGKIVSWLE MEYGLSEKES KASESFLLAA FLNLAMCYLK LREYTKAVEC CDKALGLDSA NEKGLYRRGE AQLLMNEFES AKGDFE (1-375 aa encoded by B C042605)

Target Information

FKBP5 is a member of the immunophilin protein family. This family plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP5 is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. The gene that encodes FKBP5 has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Kaempferol, a Phytoprogestin, Induces a Subset of Progesterone-Regulated Genes in the Uterus.

Nutrients

Bergsten TM,Li K,Lantvit DD,Murphy BT,Burdette JE

Wed Mar 15 00:00:00 EDT 2023

The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus in Vivo.

Journal of natural products

Li K,Diakite D,Austin J,Lee JH,Lantvit DD,Murphy BT,Burdette JE

Fri Jan 28 00:00:00 EST 2022

Decoding the temporal and regional specification of microglia in the developing human brain.

Cell stem cell

Li Y,Li Z,Yang M,Wang F,Zhang Y,Li R,Li Q,Gong Y,Wang B,Fan B,Wang C,Chen L,Li H,Ong J,Teng Z,Jin L,Wang YL,Du P,Jiao J

Thu Apr 07 00:00:00 EDT 2022

Blood-Based Epigenetic Markers of FKBP5 Gene Methylation in Patients With Dilated Cardiomyopathy.

Journal of the American Heart Association

Wada K,Misaka T,Yokokawa T,Kimishima Y,Kaneshiro T,Oikawa M,Yoshihisa A,Takeishi Y

Tue Nov 02 00:00:00 EDT 2021

IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhu X,Yao T,Wang R,Guo S,Wang X,Zhou Z,Zhang Y,Zhuo X,Wang R,Li JZ,Liu T,Kong X

Thu Oct 01 00:00:00 EDT 2020

Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model.

Neuro-oncology advances

Yamaguchi I,Nakajima K,Shono K,Mizobuchi Y,Fujihara T,Shikata E,Yamaguchi T,Kitazato K,Sampetrean O,Saya H,Takagi Y

Fri Apr 15 00:00:00 EDT 2022

Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model.

Neuro-oncology advances

Yamaguchi I,Nakajima K,Shono K,Mizobuchi Y,Fujihara T,Shikata E,Yamaguchi T,Kitazato K,Sampetrean O,Saya H,Takagi Y

Fri Apr 15 00:00:00 EDT 2022

Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model.

Neuro-oncology advances

Yamaguchi I,Nakajima K,Shono K,Mizobuchi Y,Fujihara T,Shikata E,Yamaguchi T,Kitazato K,Sampetrean O,Saya H,Takagi Y

Fri Apr 15 00:00:00 EDT 2022

Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model.

Neuro-oncology advances

Yamaguchi I,Nakajima K,Shono K,Mizobuchi Y,Fujihara T,Shikata E,Yamaguchi T,Kitazato K,Sampetrean O,Saya H,Takagi Y

Fri Apr 15 00:00:00 EDT 2022

Elective caesarean delivery and offspring's cognitive impairment: Implications of methylation alteration in hippocampus glucocorticoid signaling genes.

Brain research bulletin

Huang K,Hu Y,Sun Y,Yu Z,Liu W,Zhu P,Tao F

Tue Jan 01 00:00:00 EST 2019

Elective caesarean delivery and offspring's cognitive impairment: Implications of methylation alteration in hippocampus glucocorticoid signaling genes.

Brain research bulletin

Huang K,Hu Y,Sun Y,Yu Z,Liu W,Zhu P,Tao F

Tue Jan 01 00:00:00 EST 2019

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochemical pharmacology

Buck JM,O'Neill HC,Stitzel JA

Tue Oct 01 00:00:00 EDT 2019

MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.

Cells

Yang J,Zhang L,Cao LL,Qi J,Li P,Wang XP,Sun XL

Fri Sep 13 00:00:00 EDT 2019

MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.

Cells

Yang J,Zhang L,Cao LL,Qi J,Li P,Wang XP,Sun XL

Fri Sep 13 00:00:00 EDT 2019

A severe mouse model of spinal muscular atrophy develops early systemic inflammation.

Human molecular genetics

Wan B,Feng P,Guan Z,Sheng L,Liu Z,Hua Y

Sat Dec 01 00:00:00 EST 2018

A severe mouse model of spinal muscular atrophy develops early systemic inflammation.

Human molecular genetics

Wan B,Feng P,Guan Z,Sheng L,Liu Z,Hua Y

Sat Dec 01 00:00:00 EST 2018

Regulators of glucocorticoid receptor function in an animal model of depression and obesity.

Journal of neuroendocrinology

Kurek A,Głombik K,Detka J,Basta-Kaim A,Kubera M,Lasoń W,Budziszewska B

Fri Mar 09 00:00:00 EST 2018

Regulators of glucocorticoid receptor function in an animal model of depression and obesity.

Journal of neuroendocrinology

Kurek A,Głombik K,Detka J,Basta-Kaim A,Kubera M,Lasoń W,Budziszewska B

Fri Mar 09 00:00:00 EST 2018

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.

The EMBO journal

Luo K,Li Y,Yin Y,Li L,Wu C,Chen Y,Nowsheen S,Hu Q,Zhang L,Lou Z,Yuan J

Mon May 15 00:00:00 EDT 2017

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.

The EMBO journal

Luo K,Li Y,Yin Y,Li L,Wu C,Chen Y,Nowsheen S,Hu Q,Zhang L,Lou Z,Yuan J

Mon May 15 00:00:00 EDT 2017

The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.

RNA (New York, N.Y.)

Martinez NJ,Chang HM,Borrajo Jde R,Gregory RI

Fri Nov 01 00:00:00 EDT 2013

The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.

RNA (New York, N.Y.)

Martinez NJ,Chang HM,Borrajo Jde R,Gregory RI

Fri Nov 01 00:00:00 EDT 2013

Cell intrinsic role of COX-2 in pancreatic cancer development.

Molecular cancer therapeutics

Hill R,Li Y,Tran LM,Dry S,Calvopina JH,Garcia A,Kim C,Wang Y,Donahue TR,Herschman HR,Wu H

Mon Oct 01 00:00:00 EDT 2012

Cell intrinsic role of COX-2 in pancreatic cancer development.

Molecular cancer therapeutics

Hill R,Li Y,Tran LM,Dry S,Calvopina JH,Garcia A,Kim C,Wang Y,Donahue TR,Herschman HR,Wu H

Mon Oct 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: 51 kDa FK506-binding protein; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; EC 5.2.1.8; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP-51; FKBP54; HSP90-binding immunophilin; p54; Peptidyl-prolyl cis-trans isomerase FKBP5; peptidylprolyl cis-trans isomerase; PPIase FKBP5; Rotamase; T-cell FK506-binding protein

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Gene Aliases: AIG6; D17Ertd592e; Dit1; FKBP-5; FKBP5; FKBP51; FKBP54; P54; PPIase; Ptg-10

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UniProt ID: (Human) Q13451, (Mouse) Q64378

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Entrez Gene ID: (Human) 2289, (Mouse) 14229, (Rat) 361810

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Function(s)

peptidyl-prolyl cis-trans isomerase activity protein binding FK506 binding heat shock protein binding isomerase activity molecular_function chaperone

Process(es)

protein peptidyl-prolyl isomerization protein folding chaperone-mediated protein folding biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FKBP5 Polyclonal Antibody

FKBP5 Antibody (14155-1-AP) in IHC (P)

Product Details

14155-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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